表 1. Pharmacokinetic parameters of phenytoin sodium in epileptic rats.
不同环境癫痫大鼠体内苯妥英钠药代动力学参数
| Parameters | Normoxia (n = 8) | Hypoxia (n = 8) | t | P |
| Tmax: peak time; Cmax: peak concentration; t1/2, half-life; V: apparent volume of distribution; CL: clearance; MRT(0-t): mean residence time from 0 to t; MRT(0-∞):mean residence time from 0 to ∞; AUC(0-t): area under the curve from 0 to t; AUC(0-∞): area under the curve from 0 to ∞. | ||||
| Tmax/h | 1.63 ± 0.48 | 0.94 ± 0.17 | 3.556 | 0.0032 |
| Cmax/(μg/mL) | 9.50 ± 3.32 | 5.13 ± 2.06 | 2.959 | 0.0104 |
| t1/2/h | 8.13 ± 4.40 | 3.62 ± 0.92 | 2.653 | 0.0189 |
| V/(L/kg) | 11.57 ± 5.51 | 15.22 ± 12.10 | 0.726 | 0.4798 |
| CL/(L·h−1·kg−1) | 1.02 ± 0.17 | 2.68 ± 1.66 | 2.619 | 0.0202 |
| MRT(0-t)/h | 5.88 ± 1.19 | 4.90 ± 1.13 | 1.581 | 0.1362 |
| MRT(0-∞)/h | 9.50 ± 4.77 | 5.18 ± 1.14 | 2.333 | 0.0351 |
| AUC(0-t)/(h·μg·mL−1) | 44.79 ± 7.48 | 24.38 ± 10.88 | 4.090 | 0.0011 |
| AUC(0-∞)/(h·μg·mL−1) | 50.26 ± 8.22 | 24.59 ± 10.88 | 4.980 | 0.0002 |