NEUROBIOLOGY. For the article “Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid,” by Jiankang Liu, Elizabeth Head, Afshin M. Gharib, Wenjun Yuan, Russell T. Ingersoll, Tory M. Hagen, Carl W. Cotman, and Bruce N. Ames, which appeared in number 4, February 19, 2002, of Proc. Natl. Acad. Sci. USA (99, 2356–2361), Fig. 3 was printed incorrectly due to a printer's error. The correct figure and its legend appear below. On page 2360, right column, first full paragraph, line 16, Rna should be RNA. On page 2361, ref. 34, the author name Kuratsyne should be Kuratsune.
Figure 3.
Immunostaining relative to age and treatment for oxidized nucleic acids in neurons. (A) Representative photographs of oxo8G immunoreactivity in area CA1 of the hippocampus and adjacent white matter, from individual rats selected from young, old, old + ALCAR (0.5%), old + LA (0.2%), and old + ALCAR (0.5%) + LA (0.2%) groups. (B) CA1 sections pretreated with either DNase or RNase before incubation with Ab. (C) Extent of immunoreactivity to oxo8G in the hippocampus [CA1, CA3, CA4, dentate gyrus (DG), cerebral cortex (CX), and white matter (WM) in rat brain]. [Bar = 50 μm.] Values are mean ± SEM of 5 animals for young and old groups, 3 for old + ALCAR and old + LA groups, and 2 for the old + ALCAR + LA group. The Mann–Whitney U test was used to compare values. *, P < 0.005 vs. young rats; #, P < 0.05 vs. old control rats.