Skip to main content
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1987 Jan 3;294(6563):10–12. doi: 10.1136/bmj.294.6563.10

Reproduction of epigastric pain of duodenal ulceration by adenosine.

A H Watt, D J Lewis, J J Horne, P M Smith
PMCID: PMC1245036  PMID: 3101777

Abstract

Intravenous boluses of adenosine produced transient epigastric discomfort indistinguishable from spontaneous pain in five of six patients with endoscopically confirmed duodenal ulcer, an effect which was slightly but significantly antagonised by aminophylline. These findings may be relevant to the pathophysiology of peptic ulcer pain.

Full text

PDF
10

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belardinelli L., Shryock J., West G. A., Clemo H. F., DiMarco J. P., Berne R. M. Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts. Circulation. 1984 Dec;70(6):1083–1091. doi: 10.1161/01.cir.70.6.1083. [DOI] [PubMed] [Google Scholar]
  2. Bleehen T., Keele C. A. Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain. 1977 Aug;3(4):367–377. doi: 10.1016/0304-3959(77)90066-5. [DOI] [PubMed] [Google Scholar]
  3. Bruns R. F. Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosine. Naunyn Schmiedebergs Arch Pharmacol. 1980;315(1):5–13. doi: 10.1007/BF00504224. [DOI] [PubMed] [Google Scholar]
  4. Drury A. N., Szent-Györgyi A. The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol. 1929 Nov 25;68(3):213–237. doi: 10.1113/jphysiol.1929.sp002608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gerber J. G., Fadul S., Payne N. A., Nies A. S. Adenosine: a modulator of gastric acid secretion in vivo. J Pharmacol Exp Ther. 1984 Oct;231(1):109–113. [PubMed] [Google Scholar]
  6. Kang J. Y., Yap I., Guan R., Tay H. H. Acid perfusion of duodenal ulcer craters and ulcer pain: a controlled double blind study. Gut. 1986 Aug;27(8):942–945. doi: 10.1136/gut.27.8.942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Klabunde R. E. Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol. 1983 Sep 16;93(1-2):21–26. doi: 10.1016/0014-2999(83)90026-2. [DOI] [PubMed] [Google Scholar]
  8. Londos C., Wolff J. Two distinct adenosine-sensitive sites on adenylate cyclase. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5482–5486. doi: 10.1073/pnas.74.12.5482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mozsik G., Vizi F., Kutas J. A cellular-biochemical evaluation of gastric body mucosa and muscular layer in patients with different basal acid outputs. Scand J Gastroenterol. 1976;11(2):205–211. [PubMed] [Google Scholar]
  10. Puurunen J., Aittakumpu R., Tanskanen T. Vagally mediated stimulation of gastric acid secretion by intravenously administered adenosine derivatives in anaesthetized rats. Acta Pharmacol Toxicol (Copenh) 1986 Apr;58(4):265–271. doi: 10.1111/j.1600-0773.1986.tb00107.x. [DOI] [PubMed] [Google Scholar]
  11. Sylvén C., Beermann B., Jonzon B., Brandt R. Angina pectoris-like pain provoked by intravenous adenosine in healthy volunteers. Br Med J (Clin Res Ed) 1986 Jul 26;293(6541):227–230. doi: 10.1136/bmj.293.6541.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Watt A. H., Routledge P. A. Adenosine stimulates respiration in man. Br J Clin Pharmacol. 1985 Nov;20(5):503–506. doi: 10.1111/j.1365-2125.1985.tb05108.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Watt A. H., Routledge P. A. Transient bradycardia and subsequent sinus tachycardia produced by intravenous adenosine in healthy adult subjects. Br J Clin Pharmacol. 1986 May;21(5):533–536. doi: 10.1111/j.1365-2125.1986.tb02838.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES