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. 1987 Jan 17;294(6565):150–152. doi: 10.1136/bmj.294.6565.150

Low serum selenium concentration and glutathione peroxidase activity in intrahepatic cholestasis of pregnancy.

A Kauppila, H Korpela, U M Mäkilä, E Yrjänheikki
PMCID: PMC1245162  PMID: 3109544

Abstract

Serum selenium concentrations were found to be significantly lower in women with intrahepatic cholestasis of pregnancy than in women with normal pregnancies during the last trimester of pregnancy and post partum. The activity of the selenoenzyme glutathione peroxidase had a significant positive correlation with selenium concentration and it was also significantly lower in women with the disease. These findings suggest that selenium deficiency and reduced glutathione peroxidase activity are associated with the aetiopathogenesis of intrahepatic cholestasis of pregnancy.

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Selected References

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  1. Agostoni A., Gerli G. C., Beretta L., Palazzini G., Buso G. P., Hu X. S., Moschini G. Erythrocyte antioxidant enzymes and selenium serum levels in an Andean population. Clin Chim Acta. 1983 Sep 30;133(2):153–157. doi: 10.1016/0009-8981(83)90400-x. [DOI] [PubMed] [Google Scholar]
  2. Burk R. F., Masters B. S. Some effects of selenium deficiency on the hepatic microsomal cytochrome P-450 system in the rat. Arch Biochem Biophys. 1975 Sep;170(1):124–131. doi: 10.1016/0003-9861(75)90103-4. [DOI] [PubMed] [Google Scholar]
  3. Butler J. A., Whanger P. D., Tripp M. J. Blood selenium and glutathione peroxidase activity in pregnant women: comparative assays in primates and other animals. Am J Clin Nutr. 1982 Jul;36(1):15–23. doi: 10.1093/ajcn/36.1.15. [DOI] [PubMed] [Google Scholar]
  4. Dormandy T. L. Free-radical oxidation and antioxidants. Lancet. 1978 Mar 25;1(8065):647–650. doi: 10.1016/s0140-6736(78)91148-0. [DOI] [PubMed] [Google Scholar]
  5. Erfling W. Effect of estrogens on the liver. Case presentation. Gastroenterology. 1978 Sep;75(3):512–512. [PubMed] [Google Scholar]
  6. Kauppila A., Jouppila P., Koivisto M., Moilanen I., Ylikorkala O. Twin pregnancy. A clinical study of 335 cases. Acta Obstet Gynecol Scand Suppl. 1975;44:5–12. doi: 10.3109/00016347509156424. [DOI] [PubMed] [Google Scholar]
  7. Korpela H., Kumpulainen J., Luoma P. V., Arranto A. J., Sotaniemi E. A. Decreased serum selenium in alcoholics as related to liver structure and function. Am J Clin Nutr. 1985 Jul;42(1):147–151. doi: 10.1093/ajcn/42.1.147. [DOI] [PubMed] [Google Scholar]
  8. Little C. Steroid hydroperoxides as substrates for glutathione peroxidase. Biochim Biophys Acta. 1972 Oct 12;284(2):375–381. doi: 10.1016/0005-2744(72)90133-7. [DOI] [PubMed] [Google Scholar]
  9. Mutanen M., Koivistoinen P. The role of imported grain on the selenium intake of Finnish population in 1941-1981. Int J Vitam Nutr Res. 1983;53(1):102–108. [PubMed] [Google Scholar]
  10. Muth O. H., Weswig P. H., Whanger P. D., Oldfield J. E. Effect of feeding selenium-deficient ration to the subhuman primate (Saimiri sciureus). Am J Vet Res. 1971 Oct;32(10):1603–1605. [PubMed] [Google Scholar]
  11. Nelson S. D., Mitchell J. R., Dybing E., Sasame H. A. Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates. Biochem Biophys Res Commun. 1976 Jun 21;70(4):1157–1165. doi: 10.1016/0006-291x(76)91024-x. [DOI] [PubMed] [Google Scholar]
  12. Phillips M. J., Oda M., Mak E., Fisher M. M., Jeejeebhoy K. N. Microfilament dysfunction as a possible cause of intrahepatic cholestasis. Gastroenterology. 1975 Jul;69(1):48–58. [PubMed] [Google Scholar]
  13. Schreiber A. J., Simon F. R. Estrogen-induced cholestasis: clues to pathogenesis and treatment. Hepatology. 1983 Jul-Aug;3(4):607–613. doi: 10.1002/hep.1840030422. [DOI] [PubMed] [Google Scholar]
  14. Schwarz S. Essentiality and metabolic functions of selenium. Med Clin North Am. 1976 Jul;60(4):745–758. doi: 10.1016/s0025-7125(16)31858-2. [DOI] [PubMed] [Google Scholar]
  15. Skovby F., Kraus J. P., Rosenberg L. E. Biosynthesis of human cystathionine beta-synthase in cultured fibroblasts. J Biol Chem. 1984 Jan 10;259(1):583–587. [PubMed] [Google Scholar]
  16. Slater T. F. Free-radical mechanisms in tissue injury. Biochem J. 1984 Aug 15;222(1):1–15. doi: 10.1042/bj2220001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ursini F., Maiorino M., Gregolin C. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim Biophys Acta. 1985 Mar 29;839(1):62–70. doi: 10.1016/0304-4165(85)90182-5. [DOI] [PubMed] [Google Scholar]
  18. Ward K. P., Arthur J. R., Russell G., Aggett P. J. Blood selenium content and glutathione peroxidase activity in children with cystic fibrosis, coeliac disease, asthma, and epilepsy. Eur J Pediatr. 1984 Apr;142(1):21–24. doi: 10.1007/BF00442584. [DOI] [PubMed] [Google Scholar]

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