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. 1981 Sep;318:17–23. doi: 10.1113/jphysiol.1981.sp013847

Onset of inspiration in rabbit during artificial ventilation.

A Davies, F Sant'Ambrogio, G Sant'Ambrogio
PMCID: PMC1245474  PMID: 7033501

Abstract

1. We have investigated whether pulmonary stretch receptors are the only lung receptors determining the time of onset of inspiratory efforts in anaesthetized, paralysed rabbits. 2. New Zealand White rabbits were anaesthetized, paralysed and ventilated by intermittent positive pressure with a pattern that closely followed spontaneous breathing. Inspiratory efforts were recorded as bursts of activity in a root of the phrenic nerve. Lung stretch receptors were blocked with SO2 in air. Abolition of the Breuer-Hering reflex was used as an index of stretch receptor block. 3. With stretch receptors functioning phrenic discharge invariably occurred during the deflation phase of ventilation. With stretch receptors blocked phrenic discharge occurred with no set relation to ventilation at spontaneous resting tidal volume but was locked to inflation and deflation phases of lung volume at 30% higher tidal volumes. 4. Bilateral vagotomy produced a pattern of phrenic discharge identical with that seen with stretch receptor block and low ventilating volumes. 5. Thus we have demonstrated a vagally mediated inspiratory initiating effect; it probably originates from rapidly adapting lung irritant receptors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong D. J., Luck J. C. A comparative study of irritant and type J receptors in the cat. Respir Physiol. 1974 Jul;21(1):47–60. doi: 10.1016/0034-5687(74)90006-1. [DOI] [PubMed] [Google Scholar]
  2. Bradley G. W. Control of the breathing pattern. Int Rev Physiol. 1977;14:185–217. [PubMed] [Google Scholar]
  3. Clark F. J., von Euler C. On the regulation of depth and rate of breathing. J Physiol. 1972 Apr;222(2):267–295. doi: 10.1113/jphysiol.1972.sp009797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coleridge H. M., Coleridge J. C. Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs. Respir Physiol. 1977 Apr;29(2):125–142. doi: 10.1016/0034-5687(77)90086-x. [DOI] [PubMed] [Google Scholar]
  5. Coleridge H. M., Coleridge J. C., Luck J. C. Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol. 1965 Jul;179(2):248–262. doi: 10.1113/jphysiol.1965.sp007660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davies A., Dixon M., Callanan D., Huszczuk A., Widdicombe J. G., Wise J. C. Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide. Respir Physiol. 1978 Jul;34(1):83–101. doi: 10.1016/0034-5687(78)90050-6. [DOI] [PubMed] [Google Scholar]
  7. Davies A., Roumy M. The inspiratory augmenting effect of lung irritant receptor activity [proceeding]. J Physiol. 1978 Feb;275:14P–14P. [PubMed] [Google Scholar]
  8. Davies A. The effect of irritant receptor activity on expiratory time [proceedings]. J Physiol. 1978 Feb;275:39P–40P. [PubMed] [Google Scholar]
  9. Guz A., Trenchard D. W. The role of non-myelinated vagal afferent fibres from the lungs in the genesis of tachypnoea in the rabbit. J Physiol. 1971 Mar;213(2):345–371. doi: 10.1113/jphysiol.1971.sp009386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mills J. E., Sellick H., Widdicombe J. G. Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions. J Physiol. 1969 Aug;203(2):337–357. doi: 10.1113/jphysiol.1969.sp008867. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Paintal A. S. Vagal sensory receptors and their reflex effects. Physiol Rev. 1973 Jan;53(1):159–227. doi: 10.1152/physrev.1973.53.1.159. [DOI] [PubMed] [Google Scholar]
  12. REYNOLDS L. B., Jr Characteristics of an inspiration-augmenting reflex in anesthetized cats. J Appl Physiol. 1962 Jul;17:683–688. doi: 10.1152/jappl.1962.17.4.683. [DOI] [PubMed] [Google Scholar]
  13. TANG P. C., MAIRE F. W., AMASSIAN V. E. Respiratory influence on the vasomotor center. Am J Physiol. 1957 Nov;191(2):218–224. doi: 10.1152/ajplegacy.1957.191.2.218. [DOI] [PubMed] [Google Scholar]
  14. Widdicombe J. G., Sellick H. Vagal deflation and inflation reflexes mediated by lung irritant receptors. Q J Exp Physiol Cogn Med Sci. 1970 Apr;55(2):153–163. doi: 10.1113/expphysiol.1970.sp002060. [DOI] [PubMed] [Google Scholar]
  15. Winning A. J., Widdicombe J. G. The effect of lung reflexes on the pattern of breathing in cats. Respir Physiol. 1976 Aug;27(2):253–266. doi: 10.1016/0034-5687(76)90078-5. [DOI] [PubMed] [Google Scholar]

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