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. 1981 Sep;318:73–83. doi: 10.1113/jphysiol.1981.sp013851

The effect of dantrolene sodium on intrafusal muscle fibres in the rat soleus muscle.

G C Leslie, N J Part
PMCID: PMC1245478  PMID: 6459447

Abstract

1. The action of the skeletal muscle relaxant drug, dantrolene sodium, given intravenously, on the intrafusal fibres of the soleus muscle of the urethane-anaesthetized rat has been investigated. The experiments were made on functionally single spindle afferents and gamma fusimotor fibers isolated in dorsal and ventral roots respectively. 2. Dantrolene sodium was without effect on the discharge of primary and secondary afferents from the passive muscle spindle, nor were the dynamic indices of these endings affected. 3. Intrafusal muscle contraction was measured indirectly by means of the spindle afferent discharge. 4. The intrafusal muscle twitch contraction, as measured by means of the amplitude of the frequencygram, was depressed more slowly to a lesser extent than was the twitch of the extrafusal contraction. 5. Intrafusal contraction resulting from tetanic stimulation of the gamma fibre was depressed by dantrolene sodium to an extent dependent upon the stimulation frequency. At frequencies of 10, 25 and perhaps 50 Hz the depression was complete, that is, no afferent response was evoked; at 200 Hz stimulation, the depression was minimal (or non-existent). 6. For a muscle spindle primary ending under dynamic gamma activation dantrolene sodium caused a reduction of dynamic index whereas for the ending under static activation it caused an increase. 7. The significance of the findings in terms of the clinical use of the drug is considered.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrew B. L., Leslie G. C., Part N. J. Some observations on responses evoked by pinna stimulation in efferent and afferent fibres innervating hind limb muscle spindles of the rat. Exp Brain Res. 1979 Jan 15;34(2):263–272. doi: 10.1007/BF00235672. [DOI] [PubMed] [Google Scholar]
  2. Andrew B. L., Leslie G. C., Part N. J. Some observations on the efferent innervation of rat soleus muscle spindles. Exp Brain Res. 1978 Mar 15;31(3):433–443. doi: 10.1007/BF00237300. [DOI] [PubMed] [Google Scholar]
  3. Andrew B. L., Leslie G. C., Thompson J. Distribution and properties of muscle spindles in the caudal segmental muscles of the rat together with some comparisons with hind limb muscle spindles. Q J Exp Physiol Cogn Med Sci. 1973 Jan;58(1):19–37. doi: 10.1113/expphysiol.1973.sp002188. [DOI] [PubMed] [Google Scholar]
  4. Banker B. Q., Girvin J. P. The ultrastructural features of the mammalian muscle spindle. J Neuropathol Exp Neurol. 1971 Apr;30(2):155–195. doi: 10.1097/00005072-197104000-00001. [DOI] [PubMed] [Google Scholar]
  5. Bessou P., Laporte Y., Pagès B. Frequencygrams of spindle primary endings elicited by stimulation of static and dynamic fusimotor fibres. J Physiol. 1968 May;196(1):47–63. doi: 10.1113/jphysiol.1968.sp008493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bowman W. C., Houston J., Khan H. H., Rodger I. W. Effects of dantrolene sodium on respiratory and other muscles and on respiratory parameters in the anaesthetised cat. Eur J Pharmacol. 1979 May 1;55(3):293–303. doi: 10.1016/0014-2999(79)90197-3. [DOI] [PubMed] [Google Scholar]
  7. CROWE A., MATTHEWS P. B. THE EFFECTS OF STIMULATION OF STATIC AND DYNAMIC FUSIMOTOR FIBRES ON THE RESPONSE TO STRETCHING OF THE PRIMARY ENDINGS OF MUSCLE SPINDLES. J Physiol. 1964 Oct;174:109–131. doi: 10.1113/jphysiol.1964.sp007476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Diete-Spiff K. Tension development by isolated muscle spindles of the cat. J Physiol. 1967 Nov;193(1):31–43. doi: 10.1113/jphysiol.1967.sp008341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ellaway P. H., Murphy P. R., Trott J. R. Inhibition of gamma motoneurone discharge by contraction of the homonymous muscle in the decerebrated cat. J Physiol. 1979 Jun;291:425–441. doi: 10.1113/jphysiol.1979.sp012823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ellaway P. H., Trott J. R. Autogenetic reflex action on to gamma motoneurones by stretch of triceps surae in the decerebrated cat. J Physiol. 1978 Mar;276:49–66. doi: 10.1113/jphysiol.1978.sp012219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ellis K. O., Carpenter J. F. Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant. Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):83–94. doi: 10.1007/BF00505069. [DOI] [PubMed] [Google Scholar]
  12. Ellis K. O., Castellion A. W., Honkomp L. J., Wessels F. L., Carpenter J. E., Halliday R. P. Dantrolene, a direct acting skeletal muscle relaxant. J Pharm Sci. 1973 Jun;62(6):948–951. doi: 10.1002/jps.2600620619. [DOI] [PubMed] [Google Scholar]
  13. Emonet-Dénand F., Houk J. Etude comparative de la curarisation des synapses neuromusculaires des fibres fusimotrices gamma dynamiques et statiques, chez le chat. J Physiol (Paris) 1968 Sep-Oct;60(5):367–372. [PubMed] [Google Scholar]
  14. GRANIT R., HOMMA S., MATTHEWS P. B. Prolonged changes in the discharge of mammalian muscle spindles following tendon taps or muscle twitches. Acta Physiol Scand. 1959 Jun 24;46:185–193. doi: 10.1111/j.1748-1716.1959.tb01747.x. [DOI] [PubMed] [Google Scholar]
  15. Kotsias B. A., Muchnik S. Reversible effect of dantrolene sodium on twitch tension of rat skeletal muscle. Arch Neurol. 1978 Apr;35(4):234–236. doi: 10.1001/archneur.1978.00500280052010. [DOI] [PubMed] [Google Scholar]
  16. Leslie G. C., Part N. J. The action of dantrolene sodium on rat fast and slow muscle in vivo. Br J Pharmacol. 1981 Apr;72(4):665–672. doi: 10.1111/j.1476-5381.1981.tb09147.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nott M. W., Bowman W. C. Actions of dantrolene sodium on contractions of the tibialis anterior and soleus muscles of cats under chloralose anaesthesia. Clin Exp Pharmacol Physiol. 1974 Mar-Apr;1(2):113–122. doi: 10.1111/j.1440-1681.1974.tb00532.x. [DOI] [PubMed] [Google Scholar]
  18. Parrilla R., Gomez-Acebo J., Candela J. L. Ultrastructural evidence for the presence of enterochromaffin type II cells in the pancreatic islets of the rabbit. J Ultrastruct Res. 1969 Jan;26(1):1–7. doi: 10.1016/s0022-5320(69)90030-6. [DOI] [PubMed] [Google Scholar]
  19. Pinder R. M., Brogden R. N., Speight T. M., Avery G. S. Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity. Drugs. 1977 Jan;13(1):3–23. doi: 10.2165/00003495-197713010-00002. [DOI] [PubMed] [Google Scholar]
  20. Takauji M., Takahashi N., Nagai T. Effect of dantrolene sodium on excitation-contraction coupling in frog skeletal muscle. Jpn J Physiol. 1975;25(6):747–758. doi: 10.2170/jjphysiol.25.747. [DOI] [PubMed] [Google Scholar]
  21. Yamamoto Y., Suzuki A., Hotta K. Dissociation of excitation and contraction in skeletal muscle induced by deuterium oxide and dantrolene-sodium. Jpn J Physiol. 1977;27(1):95–109. doi: 10.2170/jjphysiol.27.95. [DOI] [PubMed] [Google Scholar]

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