Correction: Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG

Correction: Mole Med 31, 55 (2025)

https://doi.org/10.1186/s10020-025-01093-w

In this article [1], Fig. 2 panel B and Fig. 6 panel N were incorrect. For completeness and transparency, both correct and incorrect versions are displayed below.

Fig. 2.

The effect of Mig on ISO-induced cardiac fibrosis. A Schematic representation of the animal model. B Representative 1 × and 20 × images of picrosirius red-stained in heart tissues. Scale bar (upper): 2 mm, scale bar (lower): 50 μm. C Quantification of picrosirius red-stained in heart tissues (n = 6 per group). D Representative 20 × images of Col-I and α-SMA immumohistochemical staining of heart tissues. Scale bar: 100 μm. E Quantification of Col-I immumohistochemical staining of heart tissues (n = 6 per group). F Quantification of α-SMA immumohistochemical staining of heart tissues (n = 6 per group). G The expression of PCNA in heart tissues by QRT-PCR (n = 6 per group). H The expression of CTGF in heart tissues by QRT-PCR (n = 6 per group). I The expression of Fn in heart tissues by QRT-PCR (n = 6 per group). J The expression of Col-I in heart tissues by QRT-PCR (n = 6 per group). K The expression of Col-III in heart tissues by QRT-PCR (n = 6 per group). L The expression of α-SMA in heart tissues by QRT-PCR (n = 6 per group). M Representative images of PCNA, Fn and α-SMA in heart tissues by Western Blot. N The expression of PCNA in heart tissues by Western Blot (n = 6 per group). O The expression of Fn in heart tissues by Western Blot (n = 6 per group). P The expression of α-SMA in heart tissues by Western Blot (n = 6 per group). Met was used as positive control. All the genes were normalized to GAPDH. The data were. presented by Mean ± SEM, and analyzed using one-way ANOVA with Tukey’s post-hoc multiple comparison test. **, P < 0.01, ***, P < 0.001, ****, P < 0.0001 vs. CON; #, P < 0.05, ##, P < 0.01, ###, P < 0.001, ####, P < 0.0001 vs. ISO

Fig. 6.

The mechanism of Mig on cardiac fibrosis via UGCG. A Representative images of UGCG knock down in NRCFs. B Quantification of UGCG knock down on protein level in NRCFs (n = 3 per group). C Representative images of Western Blot for PCNA, CTGF, Fn, Col-I, Col-III and α-SMA on Mig during UGCG knock down in NRCFs. D Quantification of PCNA on protein level in NRCFs (n = 4 per group). E Quantification of CTGF on protein level in NRCFs (n = 4 per group). F Quantification of Fn on protein level in NRCFs (n = 4 per group). G Quantification of Col-I on protein level in NRCFs (n = 4 per group). H Quantification of Col-III on protein level in NRCFs (n = 4 per group). I Quantification of α-SMA on protein level in NRCFs (n = 4 per group). J Representative images of immunofluorescence staining of UGCG and α-SMA in NRCFs. Scale bar: 50 μm. K Representative images of ERK, STAT3, Akt and GSK-3β signal pathways on Mig during UGCG knock down in NRCFs. L Quantification of ERK signal pathway on Mig during UGCG knock down in NRCFs (n = 4 per group). M Quantification of STAT3 signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). N Quantification of Akt signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). O Quan-tification of GSK-3β signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). NRCFs were starved for 24 h. Mig and Met were added ahead for 1 h, then ISO was added for 24 h. The protein levels of PCNA, CTGF, Fn, Col-I, Col-III and α-SMA were normalized to β-Tubulin. The data were shown as mean ± SEM (one-way ANOVA with Tukey’s post-hoc multiple comparison tests). **, P < 0.01, ***, P < 0.001 vs. siNC; #, P < 0.05, #, P < 0.05, ##, P < 0.01, ###, P < 0.001 vs. siUGCG + ISO; $, P < 0.05 vs. siNC + Mig + ISO

The original article has been corrected.

Incorrect Fig. 2

Fig. 2 The effect of Mig on ISO-induced cardiac fibrosis. A Schematic representation of the animal model. B Representative 1 × and 20 × images of picrosirius red-stained in heart tissues. Scale bar (upper): 2 mm, scale bar (lower): 50 μm. C Quantification of picrosirius red-stained in heart tissues (n = 6 per group). D Representative 20 × images of Col-I and α-SMA immumohistochemical staining of heart tissues. Scale bar: 100 μm. E Quantification of Col-I immumohistochemical staining of heart tissues (n = 6 per group). F Quantification of α-SMA immumohistochemical staining of heart tissues (n = 6 per group). G The expression of PCNA in heart tissues by QRT-PCR (n = 6 per group). H The expression of CTGF in heart tissues by QRT-PCR (n = 6 per group). I The expression of Fn in heart tissues by QRT-PCR (n = 6 per group). J The expression of Col-I in heart tissues by QRT-PCR (n = 6 per group). K The expression of Col-III in heart tissues by QRT-PCR (n = 6 per group). L The expression of α-SMA in heart tissues by QRT-PCR (n = 6 per group). M Representative images of PCNA, Fn and α-SMA in heart tissues by Western Blot. N The expression of PCNA in heart tissues by Western Blot (n = 6 per group). O The expression of Fn in heart tissues by Western Blot (n = 6 per group). P The expression of α-SMA in heart tissues by Western Blot (n = 6 per group). Met was used as positive control. All the genes were normalized to GAPDH. The data were. presented by Mean ± SEM, and analyzed using one-way ANOVA with Tukey’s post-hoc multiple comparison test. **, P < 0.01, ***, P < 0.001, ****, P < 0.0001 vs. CON; #, P < 0.05, ##, P < 0.01, ###, P < 0.001, ####, P < 0.0001 vs. ISO

Correct Fig. 2

Incorrect Fig. 6

Fig. 6 The mechanism of Mig on cardiac fibrosis via UGCG. A Representative images of UGCG knock down in NRCFs. B Quantification of UGCG knock down on protein level in NRCFs (n = 3 per group). C Representative images of Western Blot for PCNA, CTGF, Fn, Col-I, Col-III and α-SMA on Mig during UGCG knock down in NRCFs. D Quantification of PCNA on protein level in NRCFs (n = 4 per group). E Quantification of CTGF on protein level in NRCFs (n = 4 per group). F Quantification of Fn on protein level in NRCFs (n = 4 per group). G Quantification of Col-I on protein level in NRCFs (n = 4 per group). H Quantification of Col-III on protein level in NRCFs (n = 4 per group). I Quantification of α-SMA on protein level in NRCFs (n = 4 per group). J Representative images of immunofluorescence staining of UGCG and α-SMA in NRCFs. Scale bar: 50 μm. K Representative images of ERK, STAT3, Akt and GSK-3β signal pathways on Mig during UGCG knock down in NRCFs. L Quantification of ERK signal pathway on Mig during UGCG knock down in NRCFs (n = 4 per group). M Quantification of STAT3 signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). N Quantification of Akt signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). O Quan-tification of GSK-3β signal pathways on Mig during UGCG knock down in NRCFs (n = 4 per group). NRCFs were starved for 24 h. Mig and Met were added ahead for 1 h, then ISO was added for 24 h. The protein levels of PCNA, CTGF, Fn, Col-I, Col-III and α-SMA were normalized to β-Tubulin. The data were shown as mean ± SEM (one-way ANOVA with Tukey’s post-hoc multiple comparison tests). **, P < 0.01, ***, P < 0.001 vs. siNC; #, P < 0.05, #, P < 0.05, ##, P < 0.01, ###, P < 0.001 vs. siUGCG + ISO; $, P < 0.05 vs. siNC + Mig + ISO

Correct Fig. 6.