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. 1981 Aug;317:21–28. doi: 10.1113/jphysiol.1981.sp013811

Stimulated gastric prostaglandin output, and the effect of inhibition of prostaglandin synthetase, in the conscious cat.

R Baker, B M Jaffe, B Shaw, C W Venables
PMCID: PMC1246775  PMID: 6796678

Abstract

1. In the conscious gastric fistula cat there was no correlation between the outputs of gastric acid and PGE secreted in response to incremental doses of pentagastrin and histamine acid phosphate. 2. PGE secreted in response to pentagastrin and histamine was not dose dependent. 3. Flurbiprofen significantly inhibited the gastric output of PGE but did not influence acid or pepsin secretion. Inhibition of PGE secretion was accompanied by evidence of gastric mucosal haemorrhage. 4. It is concluded that gastric juice PGE is unlikely to be involved in the physiological control of acid secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker R., Jaffe B. M., Reed J. D., Shaw B., Venables C. W. Endogenous prostaglandins and gastric secretion in the cat. J Physiol. 1978 May;278:451–460. doi: 10.1113/jphysiol.1978.sp012316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baker R., Jaffe B. M., Reed J. D., Shaw B., Venables C. W. Endogenous prostaglandins and stimulated gastric secretion in the cat: the effect of various secretory inhibitors. J Physiol. 1979 Jun;291:1–9. doi: 10.1113/jphysiol.1979.sp012794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baker R., Jaffe B. M., Reed J. D., Shaw B., Venables C. W. Exogenous prostaglandins and gastric secretion in the cat. J Physiol. 1978 May;278:441–450. doi: 10.1113/jphysiol.1978.sp012315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cheung L. Y., Lowry S. F., Perry J., Larson K. Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs. Gut. 1978 Sep;19(9):775–778. doi: 10.1136/gut.19.9.775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chiang L., Sanchez-Chiang L., Wolf S., Tang J. The separate determination of human pepsin and gastricsin. Proc Soc Exp Biol Med. 1966 Jul;122(3):700–704. doi: 10.3181/00379727-122-31231. [DOI] [PubMed] [Google Scholar]
  6. Coceani F., Pace-Asciak C., Volta F., Wolfe L. S. Effect of nerve stimulation on prostaglandin formation and release from the rat stomach. Am J Physiol. 1967 Oct;213(4):1056–1064. doi: 10.1152/ajplegacy.1967.213.4.1056. [DOI] [PubMed] [Google Scholar]
  7. Dajani E. Z., Driskill D. R., Bianchi R. G., Collins P. W. Comparative gastric antisecretory and antiulcer effects of prostaglandin E1 and its methyl ester in animals. Prostaglandins. 1975 Aug;10(2):205–215. doi: 10.1016/0090-6980(75)90040-4. [DOI] [PubMed] [Google Scholar]
  8. Jaffe B. M., Behrman H. R., Parker C. W. Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. J Clin Invest. 1973 Feb;52(2):398–405. doi: 10.1172/JCI107196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jaffe B. M., Smith J. W., Newton W. T., Parker C. W. Radioimmunoassay for prostaglandins. Science. 1971 Feb 5;171(3970):494–496. doi: 10.1126/science.171.3970.494. [DOI] [PubMed] [Google Scholar]
  10. Lee Y. H., Cheng W. D., Bianchi R. G., Mollison K., Hansen J. Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations. Prostaglandins. 1973 Jan;3(1):29–45. doi: 10.1016/0090-6980(73)90135-4. [DOI] [PubMed] [Google Scholar]
  11. Nezamis J. E., Robert A., Stowe D. F. Inhibition by prostaglandin E 1 of gastric secretion in the dog. J Physiol. 1971 Oct;218(2):369–383. doi: 10.1113/jphysiol.1971.sp009623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nicoloff D. M. Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog. Arch Surg. 1968 Nov;97(5):809–815. doi: 10.1001/archsurg.1968.01340050149024. [DOI] [PubMed] [Google Scholar]
  13. O'Brien P. E., Carter D. C. Effect of gastric secretory inhibitors on the gastric mucosal barrier. Gut. 1975 Jun;16(6):437–442. doi: 10.1136/gut.16.6.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pace-Asciak C. Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds. Biochim Biophys Acta. 1972 Sep 7;280(1):161–171. doi: 10.1016/0005-2760(72)90221-4. [DOI] [PubMed] [Google Scholar]
  15. Pace-Asciak C., Wolfe L. S. Biosynthesis of prostaglandins E2 and F2-alpha from tritium-labelled arachidonic acid by rat stomach homogenates. Biochim Biophys Acta. 1970 Dec 15;218(3):539–542. doi: 10.1016/0005-2760(70)90017-2. [DOI] [PubMed] [Google Scholar]
  16. Robert A., Schultz J. R., Nezamis J. E., Lancaster C. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology. 1976 Mar;70(3):359–370. [PubMed] [Google Scholar]
  17. Robert A., Stowe D. F., Nezamis J. E. Prevention of duodenal ulcers by administration of prostaglandin E 2 (PGE 2 ). Scand J Gastroenterol. 1971;6(4):303–305. doi: 10.3109/00365527109181124. [DOI] [PubMed] [Google Scholar]
  18. Whittle B. J., Boughton-Smith N. K., Moncada S., Vane J. R. Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro. Prostaglandins. 1978 Jun;15(6):955–967. doi: 10.1016/0090-6980(78)90038-2. [DOI] [PubMed] [Google Scholar]

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