Skip to main content
PMC home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1987 Aug 1;295(6593):311–314. doi: 10.1136/bmj.295.6593.311

Heart and lung transplantation in patients with end stage lung disease.

A Penketh 1, T Higenbottam 1, M Hakim 1, J Wallwork 1
PMCID: PMC1247151  PMID: 3115428

Abstract

Combined heart and lung transplantation was used to treat seven patients with end stage lung disease. All were severely disabled, and their disease carried a poor prognosis. Six patients were well four to 33 months after transplantation. One patient died after 44 days from a primary cytomegalovirus pneumonia transmitted from the donor. All the survivors had normal exercise tolerance and greatly improved lung function. It is concluded that heart and lung transplantation is a suitable treatment for selected patients with end stage chronic lung disease.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Braun S. R., Birnbaum M. L., Chopra P. S. Pre- and postoperative pulmonary function abnormalities in coronary artery revascularization surgery. Chest. 1978 Mar;73(3):316–320. doi: 10.1378/chest.73.3.316. [DOI] [PubMed] [Google Scholar]
  2. Burke C. M., Theodore J., Baldwin J. C., Tazelaar H. D., Morris A. J., McGregor C., Shumway N. E., Robin E. D., Jamieson S. W. Twenty-eight cases of human heart-lung transplantation. Lancet. 1986 Mar 8;1(8480):517–519. doi: 10.1016/s0140-6736(86)90881-0. [DOI] [PubMed] [Google Scholar]
  3. Burke C. M., Theodore J., Dawkins K. D., Yousem S. A., Blank N., Billingham M. E., Van Kessel A., Jamieson S. W., Oyer P. E., Baldwin J. C. Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart-lung transplantation. Chest. 1984 Dec;86(6):824–829. doi: 10.1378/chest.86.6.824. [DOI] [PubMed] [Google Scholar]
  4. Cammer P., Strandberg K., Philipson K. Increased mucociliary transport by cholinergic stimulation. Arch Environ Health. 1974 Oct;29(4):220–224. doi: 10.1080/00039896.1974.10666572. [DOI] [PubMed] [Google Scholar]
  5. Camner P., Strandberg K., Philipson K. Increased mucociliary transport by adrenergic stimulation. Arch Environ Health. 1976 Mar-Apr;31(2):79–82. doi: 10.1080/00039896.1976.10667194. [DOI] [PubMed] [Google Scholar]
  6. Caves P. K., Stinson E. B., Billingham M. E., Rider A. K., Shumway N. E. Diagnosis of human cardiac allograft rejection by serial cardiac biopsy. J Thorac Cardiovasc Surg. 1973 Sep;66(3):461–466. [PubMed] [Google Scholar]
  7. DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dark J. H., Patterson G. A., Al-Jilaihawi A. N., Hsu H., Egan T., Cooper J. D. Experimental en bloc double-lung transplantation. Ann Thorac Surg. 1986 Oct;42(4):394–398. doi: 10.1016/s0003-4975(10)60544-9. [DOI] [PubMed] [Google Scholar]
  9. George P. M., Vissers M. C., Travis J., Winterbourn C. C., Carrell R. W. A genetically engineered mutant of alpha 1-antitrypsin protects connective tissue from neutrophil damage and may be useful in lung disease. Lancet. 1984 Dec 22;2(8417-8418):1426–1428. doi: 10.1016/s0140-6736(84)91623-4. [DOI] [PubMed] [Google Scholar]
  10. Hakim M., Wreghitt T. G., English T. A., Stovin P. G., Cory-Pearce R., Wallwork J. Significance of donor transmitted disease in cardiac transplantation. J Heart Transplant. 1985 May;4(3):302–306. [PubMed] [Google Scholar]
  11. Jamieson S. W., Stinson E. B., Oyer P. E., Baldwin J. C., Shumway N. E. Operative technique for heart-lung transplantation. J Thorac Cardiovasc Surg. 1984 Jun;87(6):930–935. [PubMed] [Google Scholar]
  12. Jones D. K., Hakim M., Wallwork J., Higenbottam T. W., White D. J. Serious interaction between cyclosporin A and sulphadimidine. Br Med J (Clin Res Ed) 1986 Mar 15;292(6522):728–729. doi: 10.1136/bmj.292.6522.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McCarthy M. M., Rourk M. H., Spock A. Bacteremia in patients with cystic fibrosis. Clin Pediatr (Phila) 1980 Nov;19(11):746–748. doi: 10.1177/000992288001901106. [DOI] [PubMed] [Google Scholar]
  14. McGregor C. G., Baldwin J. C., Jamieson S. W., Billingham M. E., Yousem S. A., Burke C. M., Oyer P. E., Stinson E. B., Shumway N. E. Isolated pulmonary rejection after combined heart-lung transplantation. J Thorac Cardiovasc Surg. 1985 Oct;90(4):623–626. [PubMed] [Google Scholar]
  15. Myers B. D., Ross J., Newton L., Luetscher J., Perlroth M. Cyclosporine-associated chronic nephropathy. N Engl J Med. 1984 Sep 13;311(11):699–705. doi: 10.1056/NEJM198409133111103. [DOI] [PubMed] [Google Scholar]
  16. Nelems J. M., Rebuck A. S., Cooper J. D., Goldberg M., Halloran P. F., Vellend H. Human lung transplantation. Chest. 1980 Oct;78(4):569–573. doi: 10.1378/chest.78.4.569. [DOI] [PubMed] [Google Scholar]
  17. Nelson L. A., Callerame M. L., Schwartz R. H. Aspergillosis and atopy in cystic fibrosis. Am Rev Respir Dis. 1979 Oct;120(4):863–873. doi: 10.1164/arrd.1979.120.4.863. [DOI] [PubMed] [Google Scholar]
  18. Penketh A. R., Knight R. K., Hodson M. E., Batten J. C. Management of pneumothorax in adults with cystic fibrosis. Thorax. 1982 Nov;37(11):850–853. doi: 10.1136/thx.37.11.850. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Puska P., Iacono J. M., Nissinen A., Korhonen H. J., Vartianinen E., Pietinen P., Dougherty R., Leino U., Mutanen M., Moisio S. Controlled, randomised trial of the effect of dietary fat on blood pressure. Lancet. 1983 Jan 1;1(8314-5):1–5. doi: 10.1016/s0140-6736(83)91556-8. [DOI] [PubMed] [Google Scholar]
  20. Reitz B. A., Wallwork J. L., Hunt S. A., Pennock J. L., Billingham M. E., Oyer P. E., Stinson E. B., Shumway N. E. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med. 1982 Mar 11;306(10):557–564. doi: 10.1056/NEJM198203113061001. [DOI] [PubMed] [Google Scholar]
  21. Stevens P. M., Johnson P. C., Bell R. L., Beall A. C., Jr, Jenkins D. E. Regional ventilation and perfusion after lung transplantation in patients with emphysema. N Engl J Med. 1970 Jan 29;282(5):245–249. doi: 10.1056/NEJM197001292820504. [DOI] [PubMed] [Google Scholar]
  22. Theodore J., Jamieson S. W., Burke C. M., Reitz B. A., Stinson E. B., Van Kessel A., Dawkins K. D., Herran J. J., Oyer P. E., Hunt S. A. Physiologic aspects of human heart-lung transplantation. Pulmonary function status of the post-transplanted lung. Chest. 1984 Sep;86(3):349–357. doi: 10.1378/chest.86.3.349. [DOI] [PubMed] [Google Scholar]
  23. Veith F. J. Lung transplantation in perspective. N Engl J Med. 1986 May 1;314(18):1186–1187. doi: 10.1056/NEJM198605013141810. [DOI] [PubMed] [Google Scholar]
  24. Wood R. E., Boat T. F., Doershuk C. F. Cystic fibrosis. Am Rev Respir Dis. 1976 Jun;113(6):833–878. doi: 10.1164/arrd.1976.113.6.833. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES