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British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1987 Aug 29;295(6597):530–532. doi: 10.1136/bmj.295.6597.530

Hepatitis B in general practice: epidemiology, clinical and serological features, and control.

W B Clee 1, P R Hunter 1
PMCID: PMC1247438  PMID: 3117212

Abstract

In an outbreak of hepatitis B virus infection in a south Wales village 31 cases were identified over 16 months. Spread of the infection was by sharing needles and by sexual contact. Twenty seven patients were known to have symptoms, of whom nine had an anicteric illness. Generally the illness was mild with no deaths, and there was only one chronic carrier. Two patients were only transiently positive for hepatitis B surface antigen. The outbreak was controlled by vigorous contact tracing and counselling. Despite an enormous increase in workload for the general practitioner and problems including disposal of contaminated needles, outbreaks of hepatitis B virus infection may adequately be treated in the community.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler M. W., Belsey E. M., McCutchan J. A., Mindel A. Should homosexuals be vaccinated against hepatitis B virus? Cost and benefit assessment. Br Med J (Clin Res Ed) 1983 May 21;286(6378):1621–1624. doi: 10.1136/bmj.286.6378.1621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ahtone J., Maynard J. E. Laboratory diagnosis of hepatitis B. JAMA. 1983 Apr 15;249(15):2067–2069. [PubMed] [Google Scholar]
  3. Cocchi P., Silenzi M., Corti R., Nieri R., De Majo E., Parri F. Risk of contracting hepatitis B from discarded syringes. Lancet. 1984 Jun 16;1(8390):1356–1356. doi: 10.1016/s0140-6736(84)91854-3. [DOI] [PubMed] [Google Scholar]
  4. Dietzman D. E., Harnisch J. P., Ray C. G., Alexander E. R., Holmes K. K. Hepatitis B surface antigen (HBsAg) and antibody to HBsAg. Prevalence in homosexual and heterosexual men. JAMA. 1977 Dec 12;238(24):2625–2626. [PubMed] [Google Scholar]
  5. Floreani A., Chiaramonte M., Zago E., Stivanello A., Trivello R., Renzulli G., Naccarato R. Hepatitis B virus serum markers (HBsAg, antiHBs, antiHBc): prevalence among drug addicts in north-east Italy. Boll Ist Sieroter Milan. 1981;60(6):535–537. [PubMed] [Google Scholar]
  6. Francis D. P., Maynard J. E. The transmission and outcome of hepatitis A, B, and non-A, non-B: a review. Epidemiol Rev. 1979;1:17–31. doi: 10.1093/oxfordjournals.epirev.a036208. [DOI] [PubMed] [Google Scholar]
  7. Hoofnagle J. H., Seeff L. B., Bales Z. B., Zimmerman H. J. Type B hepatitis after transfusion with blood containing antibody to hepatitis B core antigen. N Engl J Med. 1978 Jun 22;298(25):1379–1383. doi: 10.1056/NEJM197806222982502. [DOI] [PubMed] [Google Scholar]
  8. Judson F. N. Epidemiology of sexually transmitted hepatitis B infections in heterosexuals: a review. Sex Transm Dis. 1981 Oct-Dec;8(4 Suppl):336–343. [PubMed] [Google Scholar]
  9. Kunches L. M., Craven D. E., Werner B. G. Seroprevalence of hepatitis B virus and delta agent in parenteral drug abusers. Immunogenicity of hepatitis B vaccine. Am J Med. 1986 Oct;81(4):591–595. doi: 10.1016/0002-9343(86)90542-5. [DOI] [PubMed] [Google Scholar]
  10. Mulley A. G., Silverstein M. D., Dienstag J. L. Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis. N Engl J Med. 1982 Sep 9;307(11):644–652. doi: 10.1056/NEJM198209093071103. [DOI] [PubMed] [Google Scholar]
  11. Okada K., Kamiyama I., Inomata M., Imai M., Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1;294(14):746–749. doi: 10.1056/NEJM197604012941402. [DOI] [PubMed] [Google Scholar]
  12. Polakoff S. Acute viral hepatitis B: laboratory reports 1980-4. Br Med J (Clin Res Ed) 1986 Jul 5;293(6538):37–38. doi: 10.1136/bmj.293.6538.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Redeker A. G., Mosley J. W., Gocke D. J., McKee A. P., Pollack W. Hepatitis B immune globulin as a prophylactic measure for spouses exposed to acute type B hepatitis. N Engl J Med. 1975 Nov 20;293(21):1055–1059. doi: 10.1056/NEJM197511202932101. [DOI] [PubMed] [Google Scholar]
  14. Roumeliotou-Karayannis A., Papaevangelou G., Tassopoulos N., Richardson S. C., Krugman S. Post-exposure active immunoprophylaxis of spouses of acute viral hepatitis B patients. Vaccine. 1985 Mar;3(1):31–34. doi: 10.1016/0264-410x(85)90007-6. [DOI] [PubMed] [Google Scholar]
  15. Schreeder M. T., Thompson S. E., Hadler S. C., Berquist K. R., Zaidi A., Maynard J. E., Ostrow D., Judson F. N., Braff E. H., Nylund T. Hepatitis B in homosexual men: prevalence of infection and factors related to transmission. J Infect Dis. 1982 Jul;146(1):7–15. doi: 10.1093/infdis/146.1.7. [DOI] [PubMed] [Google Scholar]
  16. Stevens C. E., Neurath R. A., Beasley R. P., Szmuness W. HBeAg and anti-HBe detection by radioimmunoassay: correlation with vertical transmission of hepatitis B virus in Taiwan. J Med Virol. 1979;3(3):237–241. doi: 10.1002/jmv.1890030310. [DOI] [PubMed] [Google Scholar]
  17. Zanetti A. R., Ferroni P., Magliano E. M., Pirovano P., Lavarini C., Massaro A. L., Gavinelli R., Fabris C., Rizzetto M. Perinatal transmission of the hepatitis B virus and of the HBV-associated delta agent from mothers to offspring in northern Italy. J Med Virol. 1982;9(2):139–148. doi: 10.1002/jmv.1890090209. [DOI] [PubMed] [Google Scholar]

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