HanBin Qin
HanBin Qin
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
Conceptualization, Data curation, Writing – original draft, Writing – review & editing
1,2,3,4,5,†,#,
Jiaxin Sui
Jiaxin Sui
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
6Qingdao Medical College of Qingdao University, Qingdao, China
Investigation, Writing – review & editing
2,3,4,5,6,†,#,
Shuang Wang
Shuang Wang
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
Conceptualization, Project administration, Writing – review & editing
1,2,3,4,5,
Xiaojing Lv
Xiaojing Lv
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
6Qingdao Medical College of Qingdao University, Qingdao, China
Data curation, Investigation, Validation, Writing – original draft
3,4,5,6,
Zile Zhang
Zile Zhang
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
7The 2nd Medical College of Binzhou Medical University, Yantai, China
Resources, Visualization, Investigation, Writing – original draft
2,3,4,5,7,
Xinhua Lin
Xinhua Lin
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
Writing – original draft
1,2,3,4,5,
Xuexia Liu
Xuexia Liu
8Shandong Stem Cell Engineering Technology Research Center, Central Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
Investigation, Supervision, Writing – review & editing, Writing – original draft
8,*,‡,
Hua Zhang
Hua Zhang
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
Data curation, Project administration, Resources, Writing – review & editing, Writing – original draft
2,3,4,5,*,‡
1School of Clinical Medicine, Shandong Second Medical University, Weifang, China
2Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
3Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, China
4Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
5Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, China
6Qingdao Medical College of Qingdao University, Qingdao, China
7The 2nd Medical College of Binzhou Medical University, Yantai, China
8Shandong Stem Cell Engineering Technology Research Center, Central Laboratory, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China
*Correspondence: Xuexia Liu xue6er6@163.com Hua Zhang zhang0hua@163.com
†These authors share first authorship
‡These authors have contributed equally to this work
Roles
HanBin Qin: Conceptualization, Data curation, Writing – original draft, Writing – review & editing
Jiaxin Sui: Investigation, Writing – review & editing
Shuang Wang: Conceptualization, Project administration, Writing – review & editing
Xiaojing Lv: Data curation, Investigation, Validation, Writing – original draft
Zile Zhang: Resources, Visualization, Investigation, Writing – original draft
Xinhua Lin: Writing – original draft
Xuexia Liu: Investigation, Supervision, Writing – review & editing, Writing – original draft
Hua Zhang: Data curation, Project administration, Resources, Writing – review & editing, Writing – original draft
Received 2025 Jul 19; Accepted 2025 Sep 2; Collection date 2025.
Keywords: allergic diseases, gut microbiota, metabolome, microbiota dysbiosis, mechanisms of immunity
© 2025 Qin, Sui, Wang, Lv, Zhang, Lin, Liu and Zhang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
