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. 1981 Jul;316:153–161. doi: 10.1113/jphysiol.1981.sp013779

Applicability of models for carrier-mediated serotonin transport to pools of serotonin in intact human platelets.

J L Costa, D L Murphy, H Stark
PMCID: PMC1248141  PMID: 7320861

Abstract

Intact human platelets can accumulate serotonin (5HT) in compartments which are vesicular (thrombin-releasable) or extra-vesicular (non-thrombin-releasable). 1. The net accumulation of extracellular 5HT in either compartment is not coupled in a reciprocal fashion to the presence of appropriate sodium gradients across the cell plasma membrane, and 5HT already present in either compartment is not removed when trans-membrane sodium gradients are abolished or reversed. 2. Net counter-transport of 5HT in either compartment is not detectable. 3. The data are not consistent with transport models such as that for glucose in which appropriate sodium gradients produce gradients of a co-transported molecule, or with models in which counter-transport can occur.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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