Abstract
1. The electrical activity of the antrum and duodenum was recorded from chronically implanted electrodes in six conscious dogs fitted with gastric and/or duodenal cannulae. Antral and duodenal pH were concomitantly registered using glass electrodes inserted through the respective cannula. 2. In dogs fasted for 18-24 h an alkalinization of the antrum of about 5 pH units lasting 15-30 min occurred regularly at 90-120 min intervals at the cessation of a period of antral spiking activity. This antral alkaline period was accompanied by the reflex of intestinal juice into the stomach, as determined by the presence of bile salts in gastric samples. 3. The antral pH rise was related to the development of a phase of regular spiking activity (RSA), or activity front, on the proximal duodenum concomitant with the motor quiescence of the antrum. The rise in pH disappeared after occlusion of the pylorus, which prevented the passage of duodenal contents into the antrum. 4. It is concluded that the mean antral pH value is 5.8 for half the recording time in fasted dogs, the causative factor of this alkalinization being the regurgitation of duodenal contents into the antrum while quiescent. Accordingly, more alkaline duodenal contents were observed during the occurrence of the RSA phase and the following gastro-duodenal quiescence; then the progressive acidification of the gastric and duodenal contents when the motility reappeared may be an inducing factor of a new RSA phase.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bueno L., Fioramonti J., Ruckebusch Y. Rate of flow of digesta and electrical activity of the small intestine in dogs and sheep. J Physiol. 1975 Jul;249(1):69–85. doi: 10.1113/jphysiol.1975.sp011003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bueno L., Rayner V., Ruckebusch Y. Initiation of the migrating myoelectric complex in dogs. J Physiol. 1981 Jul;316:309–318. doi: 10.1113/jphysiol.1981.sp013789. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Code C. F., Marlett J. A. The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol. 1975 Mar;246(2):289–309. doi: 10.1113/jphysiol.1975.sp010891. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Itoh Z., Aizawa I., Takeuchi S., Takayanagi R. Diurnal changes in gastric motor activity in conscious dogs. Am J Dig Dis. 1977 Feb;22(2):117–124. doi: 10.1007/BF01072953. [DOI] [PubMed] [Google Scholar]
- Itoh Z., Honda R., Aizawa I. Diurnal pH changes in duodenum of conscious dogs. Am J Physiol. 1980 Feb;238(2):G91–G96. doi: 10.1152/ajpgi.1980.238.2.G91. [DOI] [PubMed] [Google Scholar]
- Lewis T. D., Collins S. M., Fox J. E., Daniel E. E. Initiation of duodenal acid-induced motor complexes. Gastroenterology. 1979 Dec;77(6):1217–1224. [PubMed] [Google Scholar]
- Roborgh J. R. Motility cycles in the stomach of the fasting dog. Acta Physiol Pharmacol Neerl. 1966;14(1):12–17. [PubMed] [Google Scholar]
- Ruckebusch Y. Proceedings: Interaction of duodenal and antral activity in sheep and dogs. J Physiol. 1976 Jan;254(1):79P–80P. [PubMed] [Google Scholar]
- Ruckebusch Y. The electrical activity of the digestive tract of the sheep as an indication of the mechanical events in various regions. J Physiol. 1970 Nov;210(4):857–882. doi: 10.1113/jphysiol.1970.sp009246. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vantrappen G. R., Peeters T. L., Janssens J. The secretory component of the interdigestive migrating motor complex in man. Scand J Gastroenterol. 1979;14(6):663–667. doi: 10.3109/00365527909181934. [DOI] [PubMed] [Google Scholar]