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. 1982;324:365–374. doi: 10.1113/jphysiol.1982.sp014117

Hypoxic cardiac hypertrophy is not inhibited by cardioselective or non-selective beta-adrenoceptor antagonists.

P Dennis, E M Vaughan Williams
PMCID: PMC1250710  PMID: 6212672

Abstract

1. Young rabbits, eight at a time, were exposed to more than 170 hr of hypoxia (O2 at 70-80 torr) at atmospheric pressure during 9-11 days. 2. The animals were injected twice daily with doses of beta-blockers up to the highest used in human therapy, or with an equivalent volume of saline. These controls were litter mates of the treated rabbits. 3. In comparison with untreated normoxic rabbits of similar age, the hypoxia induced highly significant mean increases in right ventricular dry weight (+57%, controls; +55% treated). 4. In each group, the same degree of hypertrophy was induced in the treated and control animals, irrespective of whether the drug used was a non-selective beta-blocker (propranolol) or a cardioselective drug (atenolol). 5. The right atria were also hypertrophied, though not as much as the right ventricles. 6. In all the hypertrophied tissues the water content was increased. 7. No significant change was observed in the dry weight or water content of the left ventricles of treated or control animals.

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Selected References

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  1. Amery A., De Plaen J. F., Lijnen P., McAinsh J., Reybrouck T. Relationship between blood level of atenolol and pharmacologic effect. Clin Pharmacol Ther. 1977 Jun;21(6):691–699. doi: 10.1002/cpt1977216691. [DOI] [PubMed] [Google Scholar]
  2. Barrett A. M., Carter J., Fitzgerald J. D., Hull R., Le Count D. A new type of cardioselective adrenoceptive blocking drug. Br J Pharmacol. 1973 Jun;48(2):340P–340P. [PMC free article] [PubMed] [Google Scholar]
  3. Bishop S. P., Melsen L. R. Myocardial necrosis, fibrosis, and DNA synthesis in experimental cardiac hypertrophy induced by sudden pressure overload. Circ Res. 1976 Aug;39(2):238–245. doi: 10.1161/01.res.39.2.238. [DOI] [PubMed] [Google Scholar]
  4. Claycomb W. C. Biochemical aspects of cardiac muscle differentiation. Possible control of deoxyribonucleic acid synthesis and cell differentiation by adrenergic innervation and cyclic adenosine 3':5'-monophosphate. J Biol Chem. 1976 Oct 10;251(19):6082–6089. [PubMed] [Google Scholar]
  5. Conway F. J., Fitzgerald J. D., McAinsh J., Rowlands D. J., Simpson W. T. Human pharmacokinetic and pharmacodynamic studies on the atenolo (ICI 66,082), a new cardioselective beta-adrenoceptor blocking drug. Br J Clin Pharmacol. 1976 Apr;3(2):267–272. doi: 10.1111/j.1365-2125.1976.tb00602.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dowell R. T., McManus R. E., 3rd Pressure-induced cardiac enlargement in neonatal and adult rats. Left ventricular functional characteristics and evidence of cardiac muscle cell proliferation in the neonate. Circ Res. 1978 Mar;42(3):303–310. doi: 10.1161/01.res.42.3.303. [DOI] [PubMed] [Google Scholar]
  7. Fink G. D., Fisher J. W. Stimulation of erythropoiesis by beta adrenergic agonists. I. Characterization of activity in polycythemic mice. J Pharmacol Exp Ther. 1977 Jul;202(1):192–198. [PubMed] [Google Scholar]
  8. Fink G. D., Fisher J. W. Stimulation of erythropolesis by beta adrenergic agonists. II. Mechanism of action. J Pharmacol Exp Ther. 1977 Jul;202(1):199–208. [PubMed] [Google Scholar]
  9. Fishman A. P. Hypoxia on the pulmonary circulation. How and where it acts. Circ Res. 1976 Apr;38(4):221–231. doi: 10.1161/01.res.38.4.221. [DOI] [PubMed] [Google Scholar]
  10. Limas C. J., Chan-Stier C. Myocardial chromatin activation in experimental hyperthyroidism in rats. Role of nuclear non-histone proteins. Circ Res. 1978 Mar;42(3):311–316. doi: 10.1161/01.res.42.3.311. [DOI] [PubMed] [Google Scholar]
  11. Mitchell J. R. Timolol after myocardial infarction: an answer or a new set of questions? Br Med J (Clin Res Ed) 1981 May 16;282(6276):1565–1570. doi: 10.1136/bmj.282.6276.1565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Moret P. R., Duchosal F. Effets du propranolol sur l'hypertension pulmonaire, l'hypertrophie ventriculaire droite et les altérations métaboliques myocardiques dues à l'hypoxémie aiguë de haute altitude. Schweiz Med Wochenschr. 1976 Nov 6;106(45):1564–1566. [PubMed] [Google Scholar]
  13. Nayler W. G., Slade A., Vaughan Williams E. M., Yepez C. E. Effect of prolonged beta-adrenoceptor blockade on heart weight and ultrastructure in young rabbits. Br J Pharmacol. 1980 Mar;68(3):363–371. doi: 10.1111/j.1476-5381.1980.tb14549.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ostman-Smith I. Prevention of exercise-induced cardiac hypertrophy in rats by chemical sympathectomy (guanethidine treatment). Neuroscience. 1976 Dec;1(6):497–507. doi: 10.1016/0306-4522(76)90102-0. [DOI] [PubMed] [Google Scholar]
  15. Ostádal B., Ressl J., Urbanová D., Widimský J., Procházka J., Pelouch V. The effect of beta adrenergic blockade on pulmonary hypertension, right ventricular hypertrophy and polycythaemia, induced in rats by intermittent high altitude hypoxia. Basic Res Cardiol. 1978 Sep-Oct;73(5):422–432. doi: 10.1007/BF01906523. [DOI] [PubMed] [Google Scholar]
  16. Raine A. E., Vaughan Williams E. M. Adaptational responses to prolonged beta-adrenoceptor blockade in adult rabbits. Br J Pharmacol. 1980 Oct;70(2):205–218. doi: 10.1111/j.1476-5381.1980.tb07926.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sen S., Tarazi R. C., Khairallah P. A., Bumpus F. M. Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res. 1974 Nov;35(5):775–781. doi: 10.1161/01.res.35.5.775. [DOI] [PubMed] [Google Scholar]
  18. Shand D. G., Sell C. G., Oates J. A. Hypertrophic obstructive cardiomyopathy in an infant--propranolol therapy for three years. N Engl J Med. 1971 Oct 7;285(15):843–844. doi: 10.1056/NEJM197110072851507. [DOI] [PubMed] [Google Scholar]
  19. Tasgal J., Williams E. M. The effect of prolonged propranolol administration on myocardial transmural capillary density in young rabbits. J Physiol. 1981 Jun;315:353–367. doi: 10.1113/jphysiol.1981.sp013752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thilenius O. G., Candiolo B. M., Beug J. L. Effect of adrenergic blockade on hypoxia-induced pulmonary vasoconstriction in awake dogs. Am J Physiol. 1967 Oct;213(4):990–998. doi: 10.1152/ajplegacy.1967.213.4.990. [DOI] [PubMed] [Google Scholar]
  21. Voelkel N. F., McMurtry I. F., Reeves J. T. Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. J Appl Physiol Respir Environ Exerc Physiol. 1980 Mar;48(3):473–478. doi: 10.1152/jappl.1980.48.3.473. [DOI] [PubMed] [Google Scholar]
  22. Vogel J. A., Hartley L. H., Cruz J. C., Hogan R. P. Cardiac output during exercise in sea-level residents at sea level and high altitude. J Appl Physiol. 1974 Feb;36(2):169–172. doi: 10.1152/jappl.1974.36.2.169. [DOI] [PubMed] [Google Scholar]
  23. Wachtlová M., Mares V., Ostádal B. DNA synthesis in the ventricular myocardium of young rats exposed to intermittent high altitude (IHA) hypoxia. An autoradiographic study. Virchows Arch B Cell Pathol. 1977 Sep 15;24(4):335–342. doi: 10.1007/BF02889289. [DOI] [PubMed] [Google Scholar]
  24. Wilhelmsson C., Vedin J. A., Wilhelmsen L., Tibblin G., Werkö L. Reduction of sudden deaths after myocardial infarction by treatment with alprenolol. Preliminary results. Lancet. 1974 Nov 16;2(7890):1157–1160. doi: 10.1016/s0140-6736(74)90807-1. [DOI] [PubMed] [Google Scholar]
  25. Williams E. M., Hassan M. O., Floras J. S., Sleight P., Jones J. V. Adaptation of hypertensives to treatment with cardioselective and non-selective beta-blockers. Absence of correlation between bradycardia and blood pressure control, and reduction in slope of the QT/RR relation. Br Heart J. 1980 Nov;44(5):473–487. doi: 10.1136/hrt.44.5.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Williams E. M., Raine A. E., Cabrera A. A., Whyte J. M. The effects of prolonged beta-adrenoceptor blockade on heart weight and cardiac intracellular potentials in rabbits. Cardiovasc Res. 1975 Sep;9(5):579–592. doi: 10.1093/cvr/9.5.579. [DOI] [PubMed] [Google Scholar]
  27. Zak R., Rabinowitz M. Molecular aspects of cardiac hypertrophy. Annu Rev Physiol. 1979;41:539–552. doi: 10.1146/annurev.ph.41.030179.002543. [DOI] [PubMed] [Google Scholar]

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