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. 1986 Sep;204(3):282–299.

A systematic study of host defense processes in badly injured patients.

H C Polk Jr, C D George, S R Wellhausen, K Cost, P R Davidson, M P Regan, A P Borzotta
PMCID: PMC1251278  PMID: 3019260

Abstract

A prospective study of factors predisposing to infection in badly injured patients has disclosed: the dominant roles of two specific parameters: monocyte antigen presenting capacity, and opsonic capacity of diluted serum; the potential value of further assessment of: the predictive value of plots of activated T-cells/total T-cells versus monocyte antigen presenting capacity, the apparent protective effect of the ability to sharply increase specific IgM in response to infection, and the apparent protective effect of cytomegalovirus (CMV) infection in the first 28 days after injury against major bacterial infection; the lack of value of analysis of other T- and B-cell subsets in such patients; and the need to clarify CMV and transfusion status with respect to interpretation of such data. The specific role of variable transfusion and of specific serum immunoglobulins will require further and more discriminating study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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