Skip to main content
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1986 Jan;50(1):36–41.

Experimental pneumonia in rabbits inoculated with strains of Pasteurella multocida.

D H Percy, J L Bhasin, S Rosendal
PMCID: PMC1255156  PMID: 3742355

Abstract

Domestic rabbits were inoculated with either a 3:A or 3:D serotype of Pasteurella multocida by aerosol, intravenous, or intratracheal inoculation. Different colony forming units of P. multocida were used. Animals which died or were killed after the 14 day observation period were examined macroscopically and microscopically for lesions in the lower respiratory tract. Pneumonic lesions were most consistently produced in rabbits inoculated intratracheally with serotype 3:A. Pulmonary and pleural lesions were observed in some animals inoculated intravenously with serotype 3:A. Lesions were minimal in rabbits inoculated with serotype 3:D. Of the three routes of inoculation evaluated, the intratracheal route appeared to be the best method to produce Pasteurella-associated lesions in the lower respiratory tract.

Full text

PDF
36

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bemis D. A., Greisen H. A., Appel M. J. Pathogenesis of canine bordetellosis. J Infect Dis. 1977 May;135(5):753–762. doi: 10.1093/infdis/135.5.753. [DOI] [PubMed] [Google Scholar]
  2. Carter G. R., Rundell S. W. Identification of type A strains of P multocida using staphylococcal hyaluronidase. Vet Rec. 1975 Apr 12;96(15):343–343. doi: 10.1136/vr.96.15.343. [DOI] [PubMed] [Google Scholar]
  3. Carter G. R., Subronto P. Identification of type D strains of Pasteurella multocida with acriflavine. Am J Vet Res. 1973 Feb;34(2):293–294. [PubMed] [Google Scholar]
  4. Chengappa M. M., Myers R. C., Carter G. R. A streptomycin dependent live Pasteurella multocida vaccine for the prevention of rabbit pasteurellosis. Lab Anim Sci. 1980 Jun;30(3):515–518. [PubMed] [Google Scholar]
  5. Corbeil L. B., Strayer D. S., Skaletsky E., Wunderlich A., Sell S. Immunity to pasteurellosis in compromised rabbits. Am J Vet Res. 1983 May;44(5):845–850. [PubMed] [Google Scholar]
  6. Corrigan J. J., Jr, Kiernat J. F. Effect of heparin in experimental gram-negative septicemia. J Infect Dis. 1975 Feb;131(2):138–143. doi: 10.1093/infdis/131.2.138. [DOI] [PubMed] [Google Scholar]
  7. Flatt R. E., Dungworth D. L. Enzootic pneumonia in rabbits: microbiology and comparison with lesions experimentally produced by pasteurella multocida and a chlamydial organism. Am J Vet Res. 1971 Apr;32(4):627–637. [PubMed] [Google Scholar]
  8. Friend S. C., Wilkie B. N., Thomson R. G., Barnum D. A. Bovine pneumonic pasteurellosis: experimental induction in vaccinated and nonvaccinated calves. Can J Comp Med. 1977 Jan;41(1):77–83. [PMC free article] [PubMed] [Google Scholar]
  9. Garlinghouse L. E., Jr, DiGiacomo R. F., Van Hoosier G. L., Jr, Condon J. Selective media for Pasteurella multocida and Bordetella bronchiseptica. Lab Anim Sci. 1981 Feb;31(1):39–42. [PubMed] [Google Scholar]
  10. Gaultney J. B., Wende R. D., Williams R. P. Microagglutination procedures for febrile agglutination tests. Appl Microbiol. 1971 Oct;22(4):635–640. doi: 10.1128/am.22.4.635-640.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Glorioso J. C., Jones G. W., Rush H. G., Pentler L. J., Darif C. A., Coward J. E. Adhesion of type A Pasteurella mulocida to rabbit pharyngeal cells and its possible role in rabbit respiratory tract infections. Infect Immun. 1982 Mar;35(3):1103–1109. doi: 10.1128/iai.35.3.1103-1109.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Heddleston K. L., Gallagher J. E., Rebers P. A. Fowl cholera: gel diffusion precipitin test for serotyping Pasteruella multocida from avian species. Avian Dis. 1972 Jul-Sep;16(4):925–936. [PubMed] [Google Scholar]
  13. Lu Y. S., Pakes S. P. Protection of rabbits against experimental pasteurellosis by a streptomycin-dependent Pasteurella multocida serotype 3:A live mutant vaccine. Infect Immun. 1981 Dec;34(3):1018–1024. doi: 10.1128/iai.34.3.1018-1024.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lu Y. S., Pakes S. P., Rehg J. E., Ringler D. H. Pathogenicity of a serotype 12:A Pasteurella multocida in hydrocortisone treated and nontreated rabbits. Lab Anim Sci. 1982 Jun;32(3):258–262. [PubMed] [Google Scholar]
  15. NAMIOKA S., MURATA M. Serological studies on Pasteurella multocida. I. A simplified method for capsule typing of the organism. Cornell Vet. 1961 Oct;51:498–521. [PubMed] [Google Scholar]
  16. Okerman L., Spanoghe L. Protective effects of inactivated Pasteurella vaccines in specific pathogen free rabbits. Comp Immunol Microbiol Infect Dis. 1981;4(2):223–228. doi: 10.1016/0147-9571(81)90007-2. [DOI] [PubMed] [Google Scholar]
  17. Percy D. H., Prescott J. F., Bhasin J. L. Characterization of Pasteurella multocida isolated from rabbits in Canada. Can J Comp Med. 1984 Apr;48(2):162–165. [PMC free article] [PubMed] [Google Scholar]
  18. Percy D. H., Prescott J. F., Bhasin J. L. Pasteurella multocida infection in the domestic rabbit: immunization with a streptomycin-dependent mutant. Can J Comp Med. 1985 Apr;49(2):227–230. [PMC free article] [PubMed] [Google Scholar]
  19. Prince G. H., Smith J. E. Antigenic studies on Pasteurella multocida using immunodiffusion techniques. II. Relationships with other gram-negative species. J Comp Pathol. 1966 Jul;76(3):315–320. doi: 10.1016/0021-9975(66)90012-0. [DOI] [PubMed] [Google Scholar]
  20. Scharf R. A., Monteleone S. A., Stark D. M. A modified barrier system for maintenance of Pasteurella-free rabbits. Lab Anim Sci. 1981 Oct;31(5 Pt 1):513–515. [PubMed] [Google Scholar]
  21. Thompson H., McCandlish I. A., Wright N. G. Experimental respiratory disease in dogs due to Bordetella bronchiseptica. Res Vet Sci. 1976 Jan;20(1):16–23. [PubMed] [Google Scholar]
  22. Wilkie B. N., Markham R. J., Shewen P. E. Response of calves to lung challenge exposure with Pasteurella haemolytica after parenteral or pulmonary immunization. Am J Vet Res. 1980 Nov;41(11):1773–1778. [PubMed] [Google Scholar]
  23. Yates W. D. A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory disease of cattle. Can J Comp Med. 1982 Jul;46(3):225–263. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES