Skip to main content
PMC home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1987 Jul;51(3):394–398.

Effects of glycosaminoglycan polysulfate treatment on soundness, hyaluronic acid content of synovial fluid and proteoglycan aggregate in articular cartilage of lame boars.

J J Brennan 1, F X Aherne 1, T Nakano 1
PMCID: PMC1255345  PMID: 3651896

Abstract

Eighteen lame boars were equally assigned to two treatment groups based on initial bodyweight and leg soundness. The boars were injected intramuscularly with an aqueous solution of glycosaminoglycan polysulfate or saline on day 0, 5, 10, 15, 20 and 25 and killed on day 27. The glycosaminoglycan polysulfate treatment significantly (P less than 0.05) improved leg soundness score, and resulted in an increase (P less than 0.06) in the hyaluronic acid concentration of the cubitus joint synovial fluid, and an increase (P less than 0.05) in the proportion of aggregated proteoglycans in the articular cartilage of the medial femoral condyle. Feed intake, growth rate and articular cartilage soundness score for the cubitus and stifle joints were not significantly (P greater than 0.10) affected by the treatment.

Full text

PDF
394

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asheim A., Lindblad G. Intra-articular treatment of arthritis in race-horses with sodium hyaluronate. Acta Vet Scand. 1976;17(4):379–394. doi: 10.1186/BF03547893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Auer J. A., Fackelman G. E., Gingerich D. A., Fetter A. W. Effect of hyaluronic acid in naturally occurring and experimentally induced osteoarthritis. Am J Vet Res. 1980 Apr;41(4):568–574. [PubMed] [Google Scholar]
  3. BITTER T., MUIR H. M. A modified uronic acid carbazole reaction. Anal Biochem. 1962 Oct;4:330–334. doi: 10.1016/0003-2697(62)90095-7. [DOI] [PubMed] [Google Scholar]
  4. Fujimoto K., Ueno R. Die intraartikuläre Behandlung der Arthrosis deformans des Kniegelenks mit einem Mucopolysaccharidpolyschwefelsäureester. Z Orthop Ihre Grenzgeb. 1973 Jun;111(3):310–314. [PubMed] [Google Scholar]
  5. Greiling H., Kaneko M. Die Hemmung lysosomaler Enzyme durch ein Glykosaminoglykampolysulfat. Zur Therapie chronischer Gelenkerkrankungen mit antidegenerativ wirksamen Verbindungen; ein Beitrag zur Biochemie. Arzneimittelforschung. 1973 Apr;23(4):593–597. [PubMed] [Google Scholar]
  6. Grondalen T. Osteochondrosis and arthrosis in pigs. I. Incidence in animals up to 120 kg live weight. Acta Vet Scand. 1974;15(1):1–25. doi: 10.1186/BF03547490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Heinegård D. Extraction, fractionation and characterization of proteoglycans from bovine tracheal cartilage. Biochim Biophys Acta. 1972 Nov 28;285(1):181–192. doi: 10.1016/0005-2795(72)90190-0. [DOI] [PubMed] [Google Scholar]
  8. Jourdian G. W., Wolfman M., Sarber R., Distler J. A specific, sensitive method for the determination of hyaluronate. Anal Biochem. 1979 Jul 15;96(2):474–480. doi: 10.1016/0003-2697(79)90609-2. [DOI] [PubMed] [Google Scholar]
  9. Kruze K., Fehr K., Böni A. Effect of antirheumatic drugs on cathepsin B1 from bovine spleen. Z Rheumatol. 1976 Mar-Apr;35(3-4):95–102. [PubMed] [Google Scholar]
  10. McDevitt C. A., Muir H. Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog. J Bone Joint Surg Br. 1976 Feb;58(1):94–101. doi: 10.1302/0301-620X.58B1.131804. [DOI] [PubMed] [Google Scholar]
  11. Muir H. Heberden Oration, 1976. Molecular approach to the understanding of osteoarthrosis. Ann Rheum Dis. 1977 Jun;36(3):199–208. doi: 10.1136/ard.36.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Müller W., Panse P., Brand S., Staubli A. In vivo Studie über Verteilung, Knorpelaffinität und Metabolismus von Glykosaminoglykanpolysulfat (GAGPS, Arteparon). Z Rheumatol. 1983 Nov-Dec;42(6):355–361. [PubMed] [Google Scholar]
  13. Nakano T., Thompson J. R., Aherne F. X. Cartilage proteoglycans from normal and osteochondrotic porcine joints. Can J Comp Med. 1985 Apr;49(2):219–226. [PMC free article] [PubMed] [Google Scholar]
  14. Nishikawa H., Mori I., Umemoto J. Influences of sulfated glycosaminoglycans on biosynthesis of hyaluronic acid in rabbit knee synovial membrane. Arch Biochem Biophys. 1985 Jul;240(1):146–153. doi: 10.1016/0003-9861(85)90017-7. [DOI] [PubMed] [Google Scholar]
  15. Nizolek D. J., White K. K. Corticosteroid and hyaluronic acid treatments in equine degenerative joint disease. A review. Cornell Vet. 1981 Oct;71(4):355–375. [PubMed] [Google Scholar]
  16. Oegema T. R., Jr, Hascall V. C., Dziewiatkowski D. D. Isolation and characterization of proteoglycans from the swarm rat chondrosarcoma. J Biol Chem. 1975 Aug 10;250(15):6151–6159. [PubMed] [Google Scholar]
  17. Poole A. R. Proteoglycans in health and disease: structures and functions. Biochem J. 1986 May 15;236(1):1–14. doi: 10.1042/bj2360001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rau E., Schmid C., Bach G. L. Glykosaminoglykanpolysulfat (GAGPS, Arteparon) zur Basistherapie der Arthrose. II. Vergleichende Untersuchungen, Arteparon forte und physikalische Therapie vs. nur physikalische Behandlung; Spätergebnisse. Z Rheumatol. 1977 Jul-Aug;36(7-8):265–268. [PubMed] [Google Scholar]
  19. Rose R. J. The intra-articular use of sodium hyaluronate for the treatment of osteo-arthrosis in the horse. N Z Vet J. 1979 Jan-Feb;27(1-2):5–8. doi: 10.1080/00480169.1979.34585. [DOI] [PubMed] [Google Scholar]
  20. Siegmeth W., Radi I. Vergleich von Glykosaminoglykanpolysulfat (Arteparon) und physiologischer Kochsalzlösung bei Arthrosen grosser Gelenke. Ergebnisse einer multizentrischen Doppelblindstudie. Z Rheumatol. 1983 Jul-Aug;42(4):223–228. [PubMed] [Google Scholar]
  21. Swann D. A., Radin E. L., Nazimiec M., Weisser P. A., Curran N., Lewinnek G. Role of hyaluronic acid in joint lubrication. Ann Rheum Dis. 1974 Jul;33(4):318–326. doi: 10.1136/ard.33.4.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Verbruggen G., Veys E. M. Influence of an oversulphated heparinoid upon hyaluronate metabolism of the human synovial cell in vivo. J Rheumatol. 1979 Sep-Oct;6(5):554–561. [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES