Abstract
Thirteen cats with Chediak-Higashi syndrome and 22 control cats from the same colony, were evaluated for neutropenia. The absolute neutrophil counts of the Chediak-Higashi syndrome cats were significantly less (P less than 0.05) than those of the control cats. It is concluded that Chediak-Higashi syndrome cats, like Chediak-Higashi syndrome humans, have a neutropenia associated with the other manifestations of the syndrome. Lysozyme activity which was undetectable in the serum of both Chediak-Higashi syndrome and control cats was not of use for determining if the neutropenia was the result of neutrophil destruction.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bennett J. M., Blume R. S., Wolff S. M. Characterization and significance of abnormal leukocyte granules in the beige mouse: a possible homologue for Chediak-Higashi Aleutian trait. J Lab Clin Med. 1969 Feb;73(2):235–243. [PubMed] [Google Scholar]
- Blume R. S., Bennett J. M., Yankee R. A., Wolff S. M. Defective granulocyte regulation in the Chediak-Higashi syndrome. N Engl J Med. 1968 Nov 7;279(19):1009–1015. doi: 10.1056/NEJM196811072791901. [DOI] [PubMed] [Google Scholar]
- Degliantoni G., Perussia B., Mangoni L., Trinchieri G. Inhibition of bone marrow colony formation by human natural killer cells and by natural killer cell-derived colony-inhibiting activity. J Exp Med. 1985 May 1;161(5):1152–1168. doi: 10.1084/jem.161.5.1152. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haliotis T., Roder J., Klein M., Ortaldo J., Fauci A. S., Herberman R. B. Chédiak-Higashi gene in humans I. Impairment of natural-killer function. J Exp Med. 1980 May 1;151(5):1039–1048. doi: 10.1084/jem.151.5.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kramer J. W., Davis W. C., Prieur D. J. The Chediak-Higashi syndrome of cats. Lab Invest. 1977 May;36(5):554–562. [PubMed] [Google Scholar]
- Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Prieur D. J., Collier L. L. Animal model of human disease: Chédiak-Higashi syndrome. Am J Pathol. 1978 Feb;90(2):533–536. [PMC free article] [PubMed] [Google Scholar]
- Prieur D. J., Collier L. L. Inheritance of the Chediak-Higashi syndrome in cats. J Hered. 1981 May-Jun;72(3):175–177. doi: 10.1093/oxfordjournals.jhered.a109467. [DOI] [PubMed] [Google Scholar]
- Prieur D. J., Olson H. M., Young D. M. Lysozyme deficiency-an inherited disorder of rabbits. Am J Pathol. 1974 Nov;77(2):283–298. [PMC free article] [PubMed] [Google Scholar]
- Rausch P. G., Moore T. G. Granule enzymes of polymorphonuclear neutrophils: A phylogenetic comparison. Blood. 1975 Dec;46(6):913–919. [PubMed] [Google Scholar]
- Wolff S. M. The Chediak-Higashi syndrome: studies of host defenses. Ann Intern Med. 1972 Feb;76(2):293–306. doi: 10.7326/0003-4819-76-2-293. [DOI] [PubMed] [Google Scholar]