Skip to main content
NCBI home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1987 Oct;51(4):452–459.

Protection of newborn calves against fatal multisystemic infectious bovine rhinotracheitis by feeding colostrum from vaccinated cows.

G D Mechor 1, C G Rousseaux 1, O M Radostits 1, L A Babiuk 1, L Petrie 1
PMCID: PMC1255364  PMID: 2839276

Abstract

To determine whether consumption of colostrum with high levels of serum neutralizing antibody to bovine herpesvirus 1 would protect neonatal calves from the frequently fatal multisystemic form of infectious bovine rhinotracheitis, Holstein calves were fed for 48 h after birth with either pooled colostrum from seropositive vaccinated cows or colostrum from seronegative unvaccinated cows. The serum neutralizing antibody achieved in the former calves was between 64 and 256 and the titer in the latter calves was below 8. At 48 h of age the calves were challenged by aerosolization with bovine herpesvirus 1. All five seronegative calves died or were euthanized in a moribund state between days 5 and 7 of the trial, whereas all five seropositive animals remained healthy throughout the study. Twice daily clinical examination revealed significantly lower scores in the seronegative group from 60 h postinfection. Relative lung weights were greater in the seronegative group, associated with a severe acute necrotizing bronchiolitis with fibrin exudation. The seronegative group of calves also demonstrated an acute necrotizing rumenitis, pharyngitis, glossitis, esophagitis, laryngitis and tracheitis. The seropositive animals had only small areas of subacute necrotizing fibrinopurulent rhinitis. Bovine herpesvirus 1 virus was isolated from all nasal passages of all calves but isolation of virus in the seronegative calves was made from the trachea (5/5), lung (4/5), bronchial lymph nodes (4/5), spleen (4/5), thymus (3/5), liver (2/5), rumen (2/5) and brain (1/5).(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

PDF
452

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAKER J. A., McENTEE K., GILLESPIE J. H. Effects of infectious bovine rhinotracheitis-infectious pustular vulvovaginitis (IBR-IPV) virus on newborn calves. Cornell Vet. 1960 Apr;50:156–170. [PubMed] [Google Scholar]
  2. Babiuk L. A., Wardley R. C., Rouse B. T. Defense mechanisms against bovine herpesvirus: relationship of virus-host cell events to susceptibility to antibody-complement cell lysis. Infect Immun. 1975 Nov;12(5):958–963. doi: 10.1128/iai.12.5.958-963.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brandon M. R., Watson D. L., Lascelles A. K. The mechanism of transfer of immunoglobulin into mammary secretion of cows. Aust J Exp Biol Med Sci. 1971 Dec;49(6):613–623. doi: 10.1038/icb.1971.67. [DOI] [PubMed] [Google Scholar]
  4. Corkish J. D., Richards P. A. IBR infection in calves. Vet Rec. 1983 Dec 17;113(25):603–604. [PubMed] [Google Scholar]
  5. Fleenor W. A., Stott G. H. Hydrometer test for estimation of immunoglobulin concentration in bovine colostrum. J Dairy Sci. 1980 Jun;63(6):973–977. doi: 10.3168/jds.S0022-0302(80)83034-7. [DOI] [PubMed] [Google Scholar]
  6. Forman A. J., Babiuk L. A., Baldwin F., Friend S. C. Effect of infectious bovine rhinotracheitis virus infection of calves on cell populations recovered by lung lavage. Am J Vet Res. 1982 Jul;43(7):1174–1179. [PubMed] [Google Scholar]
  7. Gratzek J. B., Jenkins R. A., Peter C. P., Ramsey F. K. Isolation and characterization of a strain of infectious bovine rhinotracheitis virus associated with enteritis in cattle: comparative developmental study by fluorescent antibody tracing and electron microscopy. Am J Vet Res. 1966 Nov;27(121):1573–1582. [PubMed] [Google Scholar]
  8. Hoerlein A. B., Jones D. L. Bovine immunoglobulins following induced parturition. J Am Vet Med Assoc. 1977 Feb 1;170(3):325–326. [PubMed] [Google Scholar]
  9. Husband A. J., Brandon M. R., Lascelles A. K. The effect of corticosteroid on absorption and endogenous production of immunoglobulins in calves. Aust J Exp Biol Med Sci. 1973 Oct;51(5):707–710. doi: 10.1038/icb.1973.67. [DOI] [PubMed] [Google Scholar]
  10. Jericho K. W., Darcel C. Q. Response of the respiratory tract of calves kept at controlled climatic conditions to bovine Herpesvirus 1 in aerosol. Can J Comp Med. 1978 Apr;42(2):156–167. [PMC free article] [PubMed] [Google Scholar]
  11. Mach J. P., Pahud J. J. Secretory IgA, a major immunoglobulin in most bovine external secretions. J Immunol. 1971 Feb;106(2):552–563. [PubMed] [Google Scholar]
  12. Marshall R. G., Frank G. H. Clinical and immunologic responses of calves with colostrally acquired maternal antibody against parainfluenza-3 virus to homologous viral infection. Am J Vet Res. 1975 Aug;36(08):1085–1089. [PubMed] [Google Scholar]
  13. Matte J. J., Girard C. L., Seoane J. R., Brisson G. J. Absorption of colostral immunoglobulin G in the newborn dairy calf. J Dairy Sci. 1982 Sep;65(9):1765–1770. doi: 10.3168/jds.S0022-0302(82)82414-4. [DOI] [PubMed] [Google Scholar]
  14. Miller R. B., Smith M. W., Lawson K. F. Some lesions observed in calves born to cows exposed to the virus of infectious bovine rhinotracheitis in the last trimester of gestation. Can J Comp Med. 1978 Oct;42(4):438–445. [PMC free article] [PubMed] [Google Scholar]
  15. Msolla P. M., Wiseman A., Allan E. M., Selman I. E. Experimental infection of cattle of different ages with infectious bovine rhinotracheitis virus (Strichen strain). J Comp Pathol. 1983 Apr;93(2):205–210. doi: 10.1016/0021-9975(83)90007-5. [DOI] [PubMed] [Google Scholar]
  16. Naylor J. M. Colostral immunity in the calf and the foal. Vet Clin North Am Large Anim Pract. 1979 Nov;1(2):331–361. doi: 10.1016/s0196-9846(17)30188-x. [DOI] [PubMed] [Google Scholar]
  17. PIERSON R. E. THE ECONOMIC LOSS ASSOCIATED WITH INFECTIOUS BOVINE RHINOTRACHEITIS IN A DAIRY HERD. J Am Vet Med Assoc. 1965 Aug 15;147:350–352. [PubMed] [Google Scholar]
  18. Peter C. P., Gratzek J. B., Ramsey F. K. Isolation and characterization of a strain of infectious bovine rhinotracheitis virus associated with enteritis in cattle: pathogenesis studies by fluorescent antibody tracing. Am J Vet Res. 1966 Nov;27(121):1583–1590. [PubMed] [Google Scholar]
  19. Reed D. E., Bicknell E. J., Bury R. J. Systemic form of infectious bovine rhinotracheitis in young calves. J Am Vet Med Assoc. 1973 Oct 1;163(7):753–755. [PubMed] [Google Scholar]
  20. Roesti R., Fey H. Messung der Serum-Immunoglobulinklassen IgG, IgM und IgA des Simmentaler Rindes. Schweiz Arch Tierheilkd. 1975 Feb;117(2):65–84. [PubMed] [Google Scholar]
  21. Rogers R. J., Knott S. G., Eaves F. W., Clague R. C. Bovine herpesvirus 1--infection of the upper alimentary tract of cattle and its association with a severe mortality. Aust Vet J. 1978 Dec;54(12):562–565. doi: 10.1111/j.1751-0813.1978.tb02413.x. [DOI] [PubMed] [Google Scholar]
  22. Ross H. M., Hunter A. R., Masson A. G., Nettleton P. F. Fatal infection of neonatal calves by infectious bovine rhinotracheitis virus. Vet Rec. 1983 Sep 3;113(10):217–218. doi: 10.1136/vr.113.10.217. [DOI] [PubMed] [Google Scholar]
  23. Rouse B. T., Babiuk L. A. Host defense mechanisms against infectious bovine rhinotracheitis virus: in vitro stimulation of sensitized lymphocytes by virus antigen. Infect Immun. 1974 Oct;10(4):681–687. doi: 10.1128/iai.10.4.681-687.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rouse B. T., Babiuk L. A. Mechanisms of recovery from Herpesvirus infections -a review. Can J Comp Med. 1978 Oct;42(4):414–427. [PMC free article] [PubMed] [Google Scholar]
  25. Shroyer E. L., Easterday B. C. Studies on the pathogenesis of infectious bovine rhinotracheitis following aerosol exposure. Cornell Vet. 1968 Jul;58(3):442–461. [PubMed] [Google Scholar]
  26. Smith M. W., Miller R. B., Svoboda I., Lawson K. F. Efficacy of an intranasal infectious bovine rhinotracheitis vaccine for the prevention of abortion in cattle. Can Vet J. 1978 Mar;19(3):63–71. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES