Abstract
The effect of a ketamine hydrochloride/acepromazine combination on the cardiopulmonary function of 11 healthy cats was studied. Test parameters included cardiac output, measured by thermodilution, heart rate, respiratory rate, arterial blood pressure (systolic, diastolic and mean) and arterial blood gas analysis. Values for systemic vascular resistance, cardiac index and stroke volume were calculated. The cardiac output, cardiac index, stroke volume, arterial blood pressure and arterial blood pH decreased significantly (p less than 0.006). The arterial CO2 increased significantly (p less than 0.006). All changes occurred during the five to 45 minute postinduction time period. The heart rate, respiratory rate, arterial O2 and systemic vascular resistance were not significantly altered. The anesthetic regime maintained an adequate plane of surgical anesthesia for 30-45 minutes.
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- Adams H. R. New perspectives in cardiopulmonary therapeutics: receptor-selective adrenergic drugs. J Am Vet Med Assoc. 1984 Nov 1;185(9):966–974. [PubMed] [Google Scholar]
- Allen D. G., Dyson D. H., Pascoe P. J., O'Grady M. R. Evaluation of a xylazine-ketamine hydrochloride combination in the cat. Can J Vet Res. 1986 Jan;50(1):23–26. [PMC free article] [PubMed] [Google Scholar]
- Allen D. G., Nymeyer D. A preliminary investigation on the use of thermodilution and echocardiography as an assessment of cardiac function in the cat. Can J Comp Med. 1983 Apr;47(2):112–117. [PMC free article] [PubMed] [Google Scholar]
- Corssen G., Allarde R., Brosch F., Arbenz G. Ketamine as the sole anesthetic in open-heart surgery. A preliminary report. Anesth Analg. 1970 Nov-Dec;49(6):1025–1031. [PubMed] [Google Scholar]
- Diaz F. A., Bianco J. A., Bello A., Beer N., Velarde H., Izquierdo J. P., Jaen R. Effects of ketamine on canine cardiovascular function. Br J Anaesth. 1976 Oct;48(10):941–946. doi: 10.1093/bja/48.10.941. [DOI] [PubMed] [Google Scholar]
- Dyson D. H., Allen D. G., McDonell W. N. Comparison of three methods for cardiac output determination in cats. Am J Vet Res. 1985 Dec;46(12):2546–2552. [PubMed] [Google Scholar]
- Dyson D. H., McDonnell W. N., Horne J. A. Accuracy of thermodilution measurement of cardiac output in low flows applicable to feline and small canine patients. Can J Comp Med. 1984 Oct;48(4):425–427. [PMC free article] [PubMed] [Google Scholar]
- Jaspar N., Mazzarelli M., Tessier C., Milic-Emili J. Effect of ketamine on control of breathing in cats. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):851–859. doi: 10.1152/jappl.1983.55.3.851. [DOI] [PubMed] [Google Scholar]
- Kayama Y. Stimulant and depressant effects of ketamine on neocortical activity in cats. Br J Anaesth. 1983 Jul;55(7):655–660. doi: 10.1093/bja/55.7.655. [DOI] [PubMed] [Google Scholar]
- Mori K., Kawamata M., Mitani H., Yamazaki Y., Fujita M. A neurophysiologic study of ketamine anesthesia in the cat. Anesthesiology. 1971 Oct;35(4):373–383. doi: 10.1097/00000542-197110000-00012. [DOI] [PubMed] [Google Scholar]
- Muir W. W. Anesthesia and the heart. J Am Vet Med Assoc. 1977 Jul 1;171(1):92–98. [PubMed] [Google Scholar]
- Nettles D. C., Herrin T. J., Mullen J. G. Ketamine induction in poor-risk patients. Anesth Analg. 1973 Jan-Feb;52(1):59–64. [PubMed] [Google Scholar]
- Popovic N. A., Mullane J. F., Yhap E. O. Effects of acetylpromazine maleate on certain cardiorespiratory responses in dogs. Am J Vet Res. 1972 Sep;33(9):1819–1824. [PubMed] [Google Scholar]
- Smith G., Thorburn J., Vance J. P., Brown D. M. The effects of ketamine on the canine coronary circulation. Anaesthesia. 1979 Jun;34(6):555–561. doi: 10.1111/j.1365-2044.1979.tb06341.x. [DOI] [PubMed] [Google Scholar]
- Spotoft H., Korshin J. D., Sørensen M. B., Skovsted P. The cardiovascular effects of ketamine used for induction of anaesthesia in patients with valvular heart disease. Can Anaesth Soc J. 1979 Nov;26(6):463–467. doi: 10.1007/BF03006157. [DOI] [PubMed] [Google Scholar]
- Traber D. L., Wilson R. D., Priano L. L. The effect of alpha-adrenergic blockade on the cardiopulmonary response to ketamine. Anesth Analg. 1971 Sep-Oct;50(5):737–742. doi: 10.1213/00000539-197150050-00010. [DOI] [PubMed] [Google Scholar]
- Turner D. M., Ilkiw J. E., Rose R. J., Warren J. M. Respiratory and cardiovascular effects of five drugs used as sedatives in the dog. Aust Vet J. 1974 Jun;50(6):260–265. doi: 10.1111/j.1751-0813.1974.tb05293.x. [DOI] [PubMed] [Google Scholar]
- Tweed W. A., Minuck M., Mymin D. Circulatory responses to ketamine anesthesia. Anesthesiology. 1972 Dec;37(6):613–619. doi: 10.1097/00000542-197212000-00008. [DOI] [PubMed] [Google Scholar]
- Valicenti J. F., Jr, Newman W. H., Bagwell E. E., Pruett J. K., Robie N. W. Myocardial contractility during induction and steady-state ketamine anesthesia. Anesth Analg. 1973 Mar;52(2):190–194. [PubMed] [Google Scholar]
- Wright M. Pharmacologic effects of ketamine and its use in veterinary medicine. J Am Vet Med Assoc. 1982 Jun 15;180(12):1462–1471. [PubMed] [Google Scholar]