Abstract
A porcine group C rotavirus was found to be the unique cause of a problem of enzootic neonatal diarrhea in a minimal disease herd composed of 190 sows on a continuous farrowing program. During the outbreaks of diarrhea, 10 to 80% of the litters were affected with a morbidity rate of 100% and case fatality rates of 5 to 10%. Clinical signs began 24 to 48 h after birth and were characterized by a profuse yellow diarrhea lasting a few days. Piglets from different outbreaks of diarrhea were necropsied. They had multifocal villous atrophy in the small intestine, especially in the ileum. Group C rotavirus was demonstrated by direct immunofluorescent staining of frozen intestinal sections and by polyacrylamide gel electrophoresis of viral RNA extracted from the intestinal contents of diarrheic piglets. The infection with clinical illness and lesions was reproduced experimentally in newborn piglets by oral inoculation of a suspension prepared from a pool of intestinal contents from diarrheic piglets.
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- Bohl E. H., Kohler E. M., Saif L. J., Cross R. F., Agnes A. G., Theil K. W. Rotavirus as a cause of diarrhea in pigs. J Am Vet Med Assoc. 1978 Feb 15;172(4):458–463. [PubMed] [Google Scholar]
- Bohl E. H., Saif L. J., Theil K. W., Agnes A. G., Cross R. F. Porcine pararotavirus: detection, differentiation from rotavirus, and pathogenesis in gnotobiotic pigs. J Clin Microbiol. 1982 Feb;15(2):312–319. doi: 10.1128/jcm.15.2.312-319.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bridger J. C., Brown J. F. Prevalence of antibody to typical and atypical rotaviruses in pigs. Vet Rec. 1985 Jan 12;116(2):50–50. doi: 10.1136/vr.116.2.50. [DOI] [PubMed] [Google Scholar]
- Bridger J. C., Clarke I. N., McCrae M. A. Characterization of an antigenically distinct porcine rotavirus. Infect Immun. 1982 Mar;35(3):1058–1062. doi: 10.1128/iai.35.3.1058-1062.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bridger J. C. Detection by electron microscopy of caliciviruses, astroviruses and rotavirus-like particles in the faeces of piglets with diarrhoea. Vet Rec. 1980 Dec 6;107(23):532–533. [PubMed] [Google Scholar]
- Chasey D., Bridger J. C., McCrae M. A. A new type of atypical rotavirus in pigs. Arch Virol. 1986;89(1-4):235–243. doi: 10.1007/BF01309892. [DOI] [PubMed] [Google Scholar]
- Chasey D., Davies P. Atypical rotaviruses in pigs and cattle. Vet Rec. 1984 Jan 7;114(1):16–17. doi: 10.1136/vr.114.1.16. [DOI] [PubMed] [Google Scholar]
- Debouck P., Pensaert M. Experimental infection of pigs with a new porcine enteric coronavirus, CV 777. Am J Vet Res. 1980 Feb;41(2):219–223. [PubMed] [Google Scholar]
- Flewett T. H. Electron microscopy in the diagnosis of infectious diarrhea. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):538–543. [PubMed] [Google Scholar]
- Hooper B. E., Haelterman E. O. Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis. Can J Comp Med. 1969 Jan;33(1):29–36. [PMC free article] [PubMed] [Google Scholar]
- Mattion N. M., Bellinzoni R. C., Blackhall J. O., La Torre J. L., Scodeller E. A. Antigenic characterization of swine rotaviruses in Argentina. J Clin Microbiol. 1989 Apr;27(4):795–798. doi: 10.1128/jcm.27.4.795-798.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morin M., Morehouse L. G., Solorzano R. F., Olson L. D. Transmissible gastroenteritis in feeder swine: clinical, immunofluorescence and histopathological obervations. Can J Comp Med. 1973 Jul;37(3):239–248. [PMC free article] [PubMed] [Google Scholar]
- Morin M., Turgeon D., Jolette J., Robinson Y., Phaneuf J. B., Sauvageau R., Beauregard M., Teuscher E., Higgins R., Larivière S. Neonatal diarrhea of pigs in Quebec: infectious causes of significant outbreaks. Can J Comp Med. 1983 Jan;47(1):11–17. [PMC free article] [PubMed] [Google Scholar]
- Pedley S., Bridger J. C., Brown J. F., McCrae M. A. Molecular characterization of rotaviruses with distinct group antigens. J Gen Virol. 1983 Oct;64(Pt 10):2093–2101. doi: 10.1099/0022-1317-64-10-2093. [DOI] [PubMed] [Google Scholar]
- Pedley S., Bridger J. C., Chasey D., McCrae M. A. Definition of two new groups of atypical rotaviruses. J Gen Virol. 1986 Jan;67(Pt 1):131–137. doi: 10.1099/0022-1317-67-1-131. [DOI] [PubMed] [Google Scholar]
- Saif L. J., Bohl E. H., Theil K. W., Cross R. F., House J. A. Rotavirus-like, calicivirus-like, and 23-nm virus-like particles associated with diarrhea in young pigs. J Clin Microbiol. 1980 Jul;12(1):105–111. doi: 10.1128/jcm.12.1.105-111.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sigolo de San Juan C., Bellinzoni R. C., Mattion N., La Torre J., Scodeller E. A. Incidence of group A and atypical rotaviruses in Brazilian pig herds. Res Vet Sci. 1986 Sep;41(2):270–272. [PubMed] [Google Scholar]
- Snodgrass D. R., Herring A. J., Campbell I., Inglis J. M., Hargreaves F. D. Comparison of atypical rotaviruses from calves, piglets, lambs and man. J Gen Virol. 1984 May;65(Pt 5):909–914. doi: 10.1099/0022-1317-65-5-909. [DOI] [PubMed] [Google Scholar]
- Theil K. W., Saif L. J., Moorhead P. D., Whitmoyer R. E. Porcine rotavirus-like virus (group B rotavirus): characterization and pathogenicity for gnotobiotic pigs. J Clin Microbiol. 1985 Mar;21(3):340–345. doi: 10.1128/jcm.21.3.340-345.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thouless M. E., Bryden A. S., Flewett T. H., Woode G. N., Bridger J. C., Snodgrass D. R., Herring J. A. Serological relationships between rotaviruses from different species as studied by complement fixation and neutralization. Arch Virol. 1977;53(4):287–294. doi: 10.1007/BF01315627. [DOI] [PubMed] [Google Scholar]
- Woode G. N., Bridger J. C., Jones J. M., Flewett T. H., Davies H. A., Davis H. A., White G. B. Morphological and antigenic relationships between viruses (rotaviruses) from acute gastroenteritis of children, calves, piglets, mice, and foals. Infect Immun. 1976 Sep;14(3):804–810. doi: 10.1128/iai.14.3.804-810.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]