Abstract
Although the small intestine of the sheep is relatively mature at birth, there are still vacuolated enterocytes present for at least 2 days in distal regions. In the distal regions, vacuolated cells possess a range of vesicle morphology which might be indicative of at least 2 separate routes for enterocyte handling of proteins taken up from the lumen. The localisation of immunoreactive immunoglobulins within the enterocytes, presumably of colostral or milk origin, in both proximal (non-vacuolated) and distal (vacuolated) regions, does not follow patterns which suggest orderly renewal at closure. It is suggested that closure is not solely brought about by epithelial cell replacement.
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- Cornell R., Walker W. A., Isselbacher K. J. Small intestinal absorption of horseradish peroxidase. A cytochemical study. Lab Invest. 1971 Jul;25(1):42–48. [PubMed] [Google Scholar]
- Dinsdale D., Healy P. J. Enzymes involved in protein transmission by the intestine of the newborn lamb. Histochem J. 1982 Sep;14(5):811–821. doi: 10.1007/BF01033630. [DOI] [PubMed] [Google Scholar]
- Gonnella P. A., Siminoski K., Murphy R. A., Neutra M. R. Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum. J Clin Invest. 1987 Jul;80(1):22–32. doi: 10.1172/JCI113051. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LECCE J. G., MORGAN D. O. Effect of dietary regimen on cessation of intestinal absorption of large molecules (closure) in the neonatal pig and lamb. J Nutr. 1962 Nov;78:263–268. doi: 10.1093/jn/78.3.263. [DOI] [PubMed] [Google Scholar]
- Moon H. W., Joel D. D. Epithelial cell migration in the small intestine of sheep and calves. Am J Vet Res. 1975 Feb;36(2):187–189. [PubMed] [Google Scholar]
- Rodewald R. Intestinal transport of antibodies in the newborn rat. J Cell Biol. 1973 Jul;58(1):189–211. doi: 10.1083/jcb.58.1.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siminoski K., Gonnella P., Bernanke J., Owen L., Neutra M., Murphy R. A. Uptake and transepithelial transport of nerve growth factor in suckling rat ileum. J Cell Biol. 1986 Nov;103(5):1979–1990. doi: 10.1083/jcb.103.5.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smeaton T. C., Simpson-Morgan M. W. Epithelial cell renewal and antibody transfer in the intestine of the foetal and neonatal lamb. Aust J Exp Biol Med Sci. 1985 Feb;63(Pt 1):41–51. doi: 10.1038/icb.1985.5. [DOI] [PubMed] [Google Scholar]
- Smith M. W., Peacock M. A. Anomalous replacement of foetal enterocytes in the neonatal pig. Proc R Soc Lond B Biol Sci. 1980 Jan 17;206(1165):411–420. doi: 10.1098/rspb.1980.0005. [DOI] [PubMed] [Google Scholar]
- Trahair J. F., Perry R. A., Silver M., Robinson P. M. Autoradiographic localization of (3H)-thymidine incorporation in the small intestinal epithelium of fetal sheep. J Pediatr Gastroenterol Nutr. 1986 Jul-Aug;5(4):648–654. doi: 10.1097/00005176-198607000-00024. [DOI] [PubMed] [Google Scholar]
- Trahair J. F., Perry R. A., Silver M., Robinson P. M. Enterocyte migration in the foetal sheep small intestine. Biol Neonate. 1986;50(4):214–220. doi: 10.1159/000242602. [DOI] [PubMed] [Google Scholar]
- Trahair J. F., Robinson P. M. Perinatal development of the small intestine of the sheep. Reprod Nutr Dev. 1986;26(6):1255–1263. doi: 10.1051/rnd:19860903. [DOI] [PubMed] [Google Scholar]
- Trahair J., Robinson P. The development of the ovine small intestine. Anat Rec. 1986 Mar;214(3):294–303. doi: 10.1002/ar.1092140309. [DOI] [PubMed] [Google Scholar]