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. 1990 Aug;171:17–23.

A role for hyaluronan in joint development.

F M Craig 1, M T Bayliss 1, G Bentley 1, C W Archer 1
PMCID: PMC1257124  PMID: 1707045

Abstract

Hyaluronan, a common connective tissue component, influences cell adhesion, migration and cytodifferentiation in vitro, and because of these properties has been postulated to have a role in morphogenesis. Its role in the development of cartilage-associated structures, such as joints, has yet to be defined. Using a biotinylated hyaluronan-binding region-link protein complex, free hyaluronan binding sites have been localised in the joint region concomitant with the first signs of cavitation (Stage 37), whereafter it is localised in the joint space and is maintained here as this enlarges. The application of our results is discussed in the context of a primary role for hyaluronan in joint cavity formation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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