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. 1990 Oct;172:39–45.

Langerhans-like cells in amphibian epidermis.

J Carrillo-Farga 1, A Castell 1, A Pérez 1, A Rondán 1
PMCID: PMC1257201  PMID: 2148747

Abstract

Langerhans cells have been described in epidermis and other stratified epithelia of mammals. In other vertebrates equivalent cells have not been found. Amphibians show skin graft rejection, so it is possible that these animals have epidermal cells homologous to Langerhans cells. In this work we demonstrate the existence of ATPase-positive dendritic cells in frog epidermis that are similar ultrastructurally to mammalian Langerhans cells, except for the absence of Birbeck granules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banerjee T. K., Hoshino T. ATP ase-positive and metallophilic cells in the skin of frog, Rana catesbeiana. Nagoya J Med Sci. 1985 Mar;47(3-4):83–90. [PubMed] [Google Scholar]
  2. Braathen L. R., Thorsby E. Human epidermal Langerhans cells are more potent than blood monocytes in inducing some antigen-specific T-cell responses. Br J Dermatol. 1983 Feb;108(2):139–146. doi: 10.1111/j.1365-2133.1983.tb00055.x. [DOI] [PubMed] [Google Scholar]
  3. Böck P. Fine structure of Langerhans cells in the stratified epithelia of the esophagus and stomach of mice. Z Zellforsch Mikrosk Anat. 1974 Feb 27;147(2):237–247. doi: 10.1007/BF00582798. [DOI] [PubMed] [Google Scholar]
  4. Drexhage H. A., Mullink H., de Groot J., Clarke J., Balfour B. M. A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the Langerhans cell. Cell Tissue Res. 1979 Nov;202(3):407–430. doi: 10.1007/BF00220434. [DOI] [PubMed] [Google Scholar]
  5. Farquhar M. G., Palade G. E. Adenosine triphosphatase localization in amphibian epidermis. J Cell Biol. 1966 Aug;30(2):359–379. doi: 10.1083/jcb.30.2.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Farquhar M. G., Palade G. E. Cell junctions in amphibian skin. J Cell Biol. 1965 Jul;26(1):263–291. doi: 10.1083/jcb.26.1.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Figueroa C. D., Caorsi I. Ultrastructural and morphometric study of the Langerhans cell in the normal human exocervix. J Anat. 1980 Dec;131(Pt 4):669–682. [PMC free article] [PubMed] [Google Scholar]
  8. Gemmell R. T. Langerhans cells in the ruminal epithelium of the sheep. J Ultrastruct Res. 1973 May;43(3):256–259. doi: 10.1016/s0022-5320(73)80037-1. [DOI] [PubMed] [Google Scholar]
  9. Green I., Stingl G., Shevach E. M., Katz S. I. Antigen presentation and allogeneic stimulation by Langerhans cells. J Invest Dermatol. 1980 Jul;75(1):44–45. doi: 10.1111/1523-1747.ep12521102. [DOI] [PubMed] [Google Scholar]
  10. Halliday G. M., Muller H. K. Langerhans cell presentation of sheep red blood cells induces antibody production. Immunol Cell Biol. 1987 Feb;65(Pt 1):71–76. doi: 10.1038/icb.1987.8. [DOI] [PubMed] [Google Scholar]
  11. Hashimoto K., Tarnowski W. M. Some new aspects of the Langerhans cell. Arch Dermatol. 1968 Apr;97(4):450–464. [PubMed] [Google Scholar]
  12. Hutchens L. H., Sagebiel R. W., Clarke M. A. Oral epithelial dendritic cells of the Rhesus monkey--histologic demonstration, fine structure and quantitative distribution. J Invest Dermatol. 1971 Apr;56(4):325–336. doi: 10.1111/1523-1747.ep12261091. [DOI] [PubMed] [Google Scholar]
  13. Juhlin L., Shelley W. B. New staining techniques for the Langerhans cell. Acta Derm Venereol. 1977;57(4):289–296. [PubMed] [Google Scholar]
  14. Katz S. I., Tamaki K., Sachs D. H. Epidermal Langerhans cells are derived from cells originating in bone marrow. Nature. 1979 Nov 15;282(5736):324–326. doi: 10.1038/282324a0. [DOI] [PubMed] [Google Scholar]
  15. Klareskog L., Tjernlund U., Forsum U., Peterson P. A. Epidermal Langerhans cells express Ia antigens. Nature. 1977 Jul 21;268(5617):248–250. doi: 10.1038/268248a0. [DOI] [PubMed] [Google Scholar]
  16. Mackenzie I. C., Squier C. A. Cytochemical identification of ATPase-positive langerhans cells in EDTA-separated sheets of mouse epidermis. Br J Dermatol. 1975 May;92(5):523–533. doi: 10.1111/j.1365-2133.1975.tb03120.x. [DOI] [PubMed] [Google Scholar]
  17. Murphy G. F., Messadi D., Fonferko E., Hancock W. W. Phenotypic transformation of macrophages to Langerhans cells in the skin. Am J Pathol. 1986 Jun;123(3):401–406. [PMC free article] [PubMed] [Google Scholar]
  18. Płytycz B. Ontogeny of transplantation immunity in the common frog, Rana temporaria L. Differentiation. 1981;20(1):71–76. doi: 10.1111/j.1432-0436.1981.tb01158.x. [DOI] [PubMed] [Google Scholar]
  19. Płytycz B. Preliminary report on skin allograft rejection in tadpoles and froglets of Rana temporaria. Dev Comp Immunol. 1980 Fall;4(4):747–752. doi: 10.1016/s0145-305x(80)80075-9. [DOI] [PubMed] [Google Scholar]
  20. Riley P. A. Esterase in epidermal dendritic cells of the mouse. A study of the histochemical properties and distribution of activity of the enzyme in relation to patterning in the tail. Br J Dermatol. 1966 Jul;78(7):388–397. doi: 10.1111/j.1365-2133.1966.tb12235.x. [DOI] [PubMed] [Google Scholar]
  21. Robins P. G., Brandon D. R. A modification of the adenosine triphosphatase method to demonstrate epidermal Langerhans cells. Stain Technol. 1981 Mar;56(2):87–89. doi: 10.3109/10520298109067287. [DOI] [PubMed] [Google Scholar]
  22. Rowden G., Lewis M. G., Sullivan A. K. Ia antigen expression on human epidermal Langerhans cells. Nature. 1977 Jul 21;268(5617):247–248. doi: 10.1038/268247a0. [DOI] [PubMed] [Google Scholar]
  23. Rowden G. The Langerhans cell. Crit Rev Immunol. 1981 Dec;3(2):95–180. [PubMed] [Google Scholar]
  24. Shelley W. B., Juhlin L. Selective uptake of contact allergens by the Langerhans cell. Arch Dermatol. 1977 Feb;113(2):187–192. [PubMed] [Google Scholar]
  25. Silberberg-Sinakin I., Thorbecke G. J., Baer R. L., Rosenthal S. A., Berezowsky V. Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes. Cell Immunol. 1976 Aug;25(2):137–151. doi: 10.1016/0008-8749(76)90105-2. [DOI] [PubMed] [Google Scholar]
  26. Silberberg I., Baer R. L., Rosenthal S. A. The role of langerhans cells in contact allergy. I. An ultrastructural study in actively induced contact dermatitis in guinea pigs. Acta Derm Venereol. 1974;54(5):321–331. [PubMed] [Google Scholar]
  27. Silberberg I. Studies by electron microscopy of epidermis after topical application of mercuric chloride. Morphologic and histochemical findings in epidermal cells of human subjects who do not show allergic sensitivity or primary irritant reactions to mercuric chloride (0.1 per cent). J Invest Dermatol. 1971 Feb;56(2):147–160. doi: 10.1111/1523-1747.ep12260723. [DOI] [PubMed] [Google Scholar]
  28. Steiner G., Wolff K., Pehamberger H., Stingl G. Epidermal cells as accessory cells in the generation of allo-reactive and hapten-specific cytotoxic T lymphocyte (CTL) responses. J Immunol. 1985 Feb;134(2):736–741. [PubMed] [Google Scholar]
  29. Stingl G., Romani N., Wolff K. Langerhans' cells: a distinctive member of bone marrow-derived dendritic cells. Adv Dermatol. 1987;2:269–281. [PubMed] [Google Scholar]
  30. Sullivan S., Bergstresser P. R., Streilein J. W. Intravenously injected, TNP-derivatized, Langerhans cell-enriched epidermal cells induce contact hypersensitivity in Syrian hamsters. J Invest Dermatol. 1985 Apr;84(4):249–252. doi: 10.1111/1523-1747.ep12265316. [DOI] [PubMed] [Google Scholar]
  31. Takahashi S., Hashimoto K. Derivation of Langerhans cell granules from cytomembrane. J Invest Dermatol. 1985 Jun;84(6):469–471. doi: 10.1111/1523-1747.ep12272389. [DOI] [PubMed] [Google Scholar]
  32. Toews G. B., Bergstresser P. R., Streilein J. W. Langerhans cells: sentinels of skin associated lymphoid tissue. J Invest Dermatol. 1980 Jul;75(1):78–82. doi: 10.1111/1523-1747.ep12521270. [DOI] [PubMed] [Google Scholar]
  33. Wolff K., Winkelmann R. K. Ultrastructural localization of nucleoside triphosphatase in Langerhans cells. J Invest Dermatol. 1967 Jan;48(1):50–54. doi: 10.1038/jid.1967.8. [DOI] [PubMed] [Google Scholar]
  34. Zelickson A. S., Mottaz J. H. Epidermal dendritic cells. A quantitative study. Arch Dermatol. 1968 Dec;98(6):652–659. [PubMed] [Google Scholar]

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