Abstract
The epithelium of the lingual dorsum of the mongoose, Herpestes edwardsi, was composed of two main areas: the interpapillary area, characterised by the absence of keratinisation; and the papillary area, characterised by hard keratinisation. The number of tonofibrils in the cytoplasm gradually increased, and the volume of the individual cells also increased, from the germinal layer to the intermediate layer of the interpapillary epithelium. No keratohyalin granules were recognised in these cells. In the cells of the surface layer of the interpapillary epithelium, most of the cytoplasm was filled with tonofilaments. The germinal layer of the papillary epithelium was almost identical to that of the interpapillary epithelium. In the intermediate layer, three different types of keratohyalin granule were apparent. The first type consisted of loosely aggregated ribosomes and had moderate electron density. The second type consisted of electron-dense granules derived from granules of the first type. The third type consisted of conjugated structures made up of tonofibrils, which were embedded in electron-dense material. Free ribosomes gradually disappeared as the keratinised layer was approached and most of the cytoplasm of cells in this layer was filled with keratin fibres.
Full text
PDF











Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bickenbach J. R., Mackenzie I. C. Identification and localization of label-retaining cells in hamster epithelia. J Invest Dermatol. 1984 Jun;82(6):618–622. doi: 10.1111/1523-1747.ep12261460. [DOI] [PubMed] [Google Scholar]
- Boshell J. L., Wilborn W. H., Singh B. B. Filiform papillae of cat tongue. Acta Anat (Basel) 1982;114(2):97–105. doi: 10.1159/000145583. [DOI] [PubMed] [Google Scholar]
- Bowden P. E., Cunliffe W. J. Modification of human prekeratin during epidermal differentiation. Biochem J. 1981 Oct 1;199(1):145–154. doi: 10.1042/bj1990145. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cane A. K., Spearman R. I. The keratinized epithelium of the house-mouse (Mus musculus) tongue: its structure and histochemistry. Arch Oral Biol. 1969 Jul;14(7):829–841. doi: 10.1016/0003-9969(69)90173-3. [DOI] [PubMed] [Google Scholar]
- Dale B. A., Holbrook K. A., Steinert P. M. Assembly of stratum corneum basic protein and keratin filaments in macrofibrils. Nature. 1978 Dec 14;276(5689):729–731. doi: 10.1038/276729a0. [DOI] [PubMed] [Google Scholar]
- Dale B. A., Thompson W. B., Stern I. B. Distribution of histidine-rich basic protein, a possible keratin matrix protein, in rat oral epithelium. Arch Oral Biol. 1982;27(7):535–545. doi: 10.1016/0003-9969(82)90067-x. [DOI] [PubMed] [Google Scholar]
- Dale B. A., Vadlamudi B., DeLap L. W., Bernstein I. A. Similarities between stratum corneum basic protein and histidine-rich protein II from newborn rat epidermis. Biochim Biophys Acta. 1981 Mar 27;668(1):98–106. doi: 10.1016/0005-2795(81)90153-7. [DOI] [PubMed] [Google Scholar]
- Dhouailly D., Xu C., Manabe M., Schermer A., Sun T. T. Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation. Exp Cell Res. 1989 Mar;181(1):141–158. doi: 10.1016/0014-4827(89)90189-4. [DOI] [PubMed] [Google Scholar]
- Eichner R., Sun T. T., Aebi U. The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol. 1986 May;102(5):1767–1777. doi: 10.1083/jcb.102.5.1767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farbman A. I. Morphological variability of keratohyalin. Anat Rec. 1966 Feb;154(2):275–285. doi: 10.1002/ar.1091540210. [DOI] [PubMed] [Google Scholar]
- Farbman A. I. The dual pattern of keratinization in filiform papillae on rat tongue. J Anat. 1970 Mar;106(Pt 2):233–242. [PMC free article] [PubMed] [Google Scholar]
- Franke W. W., Schiller D. L., Moll R., Winter S., Schmid E., Engelbrecht I., Denk H., Krepler R., Platzer B. Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J Mol Biol. 1981 Dec 25;153(4):933–959. doi: 10.1016/0022-2836(81)90460-5. [DOI] [PubMed] [Google Scholar]
- Fukuyama K., Epstein W. L. Ultrastructural autoradiographic studies of keratohyalin granule formation. J Invest Dermatol. 1967 Dec;49(6):595–604. doi: 10.1038/jid.1967.186. [DOI] [PubMed] [Google Scholar]
- Hume W. J., Potten C. S. The ordered columnar structure of mouse filiform papillae. J Cell Sci. 1976 Oct;22(1):149–160. doi: 10.1242/jcs.22.1.149. [DOI] [PubMed] [Google Scholar]
- Iwasaki S., Miyata K. Fine structure of the filiform papilla of beagle dogs. J Morphol. 1989 Sep;201(3):235–242. doi: 10.1002/jmor.1052010303. [DOI] [PubMed] [Google Scholar]
- Iwasaki S., Miyata K., Kobayashi K. Comparative studies of the dorsal surface of the tongue in three mammalian species by scanning electron microscopy. Acta Anat (Basel) 1987;128(2):140–146. doi: 10.1159/000146330. [DOI] [PubMed] [Google Scholar]
- Iwasaki S., Miyata K., Kobayashi K. The surface structure of the dorsal epithelium of tongue in the mouse. Kaibogaku Zasshi. 1987 Apr;62(2):69–76. [PubMed] [Google Scholar]
- Kitajima Y., Furuta H., Tsuneda Y., Yoneda K., Mori S. Heterogeneity of epidermal prekeratin and keratin between sole and body skin in humans. J Dermatol. 1984 Jun;11(3):211–218. doi: 10.1111/j.1346-8138.1984.tb01468.x. [DOI] [PubMed] [Google Scholar]
- Matoltsy A. G., Matoltsy M. N. The chemical nature of keratohyalin granules of the epidermis. J Cell Biol. 1970 Dec;47(3):593–603. doi: 10.1083/jcb.47.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sperry D. G., Wassersug R. J. A proposed function for microridges on epithelial cells. Anat Rec. 1976 Jun;185(2):253–257. doi: 10.1002/ar.1091850212. [DOI] [PubMed] [Google Scholar]
- Steflik D. E., Singh B. B., Mckinney R. V., Jr, Boshell J. L. Correlated TEM, SEM, and histological observations of filiform papillae of the cow tongue. Acta Anat (Basel) 1983;117(1):21–30. doi: 10.1159/000145767. [DOI] [PubMed] [Google Scholar]
- Suzuki H., Kurosumi K., Miyata C. Electron microscopy of spherical keratohyalin granules. J Invest Dermatol. 1973 Apr;60(4):219–223. doi: 10.1111/1523-1747.ep12724488. [DOI] [PubMed] [Google Scholar]
- Woodcock-Mitchell J., Eichner R., Nelson W. G., Sun T. T. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982 Nov;95(2 Pt 1):580–588. doi: 10.1083/jcb.95.2.580. [DOI] [PMC free article] [PubMed] [Google Scholar]












