This article (1) titled “The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism” (doi: 10.21037/atm-20-4819), unfortunately contains errors in Figures 1A-1E,2A-2E,3C,3D,5,7A-7E. These images were incorrectly uploaded. The corresponding part of the experiment has been repeated to reflect the correct experimental conditions. Meanwhile, the legends of Figures 1,2,3,5,7 remain intact. The corrected figures are provided below.
Original Figure 1:
Correct Figure 1:
Figure 1.
Myocardial damage to heart tissue. (A,B,C,D) H&E staining of heart tissues (×40); (E,F) histological evaluation of heart tissues; (G) cTnI levels were assessed in the mice following CLP and/or the AICAR treatment as described in the methods. *P<0.05, **P<0.01.
Original Figure 2:
Correct Figure 2:
Figure 2.
Myocardial damage to H9C2 cells. Morphological observation of H9C2 cells under phase-contrast microscopy (×200). *P<0.05.
Original Figure 3:
Correct Figure 3:
Figure 3.
UCP2 expression in heart tissue and myocardial cells. (A,B) UCP2 protein expression and representative image of immunoblotting of UCP2 in mouse heart tissues; (C,D) UCP2 protein expression and representative image of immunoblotting of UCP2 in cultured H9C2 cells subjected to various treatments. **P<0.01, ***P<0.001.
Original Figure 5:
Correct Figure 5:
Figure 5.
Mitochondrial injury in H9C2 cells (A,B,C,D): Transmission electron microscopy observation of heart tissues (×200).
Original Figure 7:
Correct Figure 7:
Figure 7.
Interaction between UCP2 and AMPK and the underlying mechanism. (A,B,C,D) pAMPK expression in heart tissue; (E) AMPK phosphorylation levels measured in heart tissue; (F) effect on protein levels in cultured H9C2 cells treated with the indicated reagents. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
The authors regret the errors and confirm that the corrections do not affect either the results or conclusions of this paper.
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References
- 1.Mao JY, Su LX, Li DK, et al. The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism. Ann Transl Med 2021;9:259. 10.21037/atm-20-4819 [DOI] [PMC free article] [PubMed] [Google Scholar]
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