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Journal of the American College of Emergency Physicians Open logoLink to Journal of the American College of Emergency Physicians Open
. 2025 Oct 25;6(6):100270. doi: 10.1016/j.acepjo.2025.100270

Diffuse Unilateral Leg Swelling

Bruce M Lo 1,, Kylie Butler 2, Navjot Kaur 2, Kirsten Pennell 1
PMCID: PMC12596202  PMID: 41216216

1. Patient Presentation

A 46-year-old woman with a history of hypertension presented with 14 days of right leg pain. The pain began after straining her leg while lifting heavy boxes at work, with diffuse leg swelling noted 3 days later. She reported subjective fever but no other complaints. Patient denies any illicit drug use. Initial vital signs included a temperature of 100.1 °F, heart rate of 122 beats per minute, and blood pressure of 158/91 mm Hg. Physical examination revealed a diffusely swollen and tender right leg (Fig 1). Computed tomography (CT) of the right leg identified a 19 × 7 × 6.2 cm fluid collection within the adductor brevis and magnus muscles (Fig 2).

Figure 1.

Figure 1

Diffuse right leg swelling with diffuse tenderness.

Figure 2.

Figure 2

Computed tomography of right leg showing a 19 × 7 × 6.2 cm fluid collection (red arrow).

2. Diagnosis: Spontaneous Pyomyositis

Pyomyositis is a rare bacterial infection of the skeletal muscle that typically results in the formation of an abscess. It is believed to involve hematogenous spread to the muscle following injury. Although traditionally considered a tropical disease, pyomyositis is now seen in nontropical regions and is associated with significant morbidity and mortality if left untreated.

Presentation can look similar to early skin infections such as cellulitis, abscess, or deep venous thrombosis and typically affect the larger muscles in the upper and lower extremities.1 Early diagnosis requires high clinical suspicion as there may be a lack of dermatologic findings to prompt imaging with either ultrasound or CT. Treatment ranges from percutaneous or surgical debridement with antimicrobial therapy. Open incision and drainage and interventional radiology drainage procedures are commonly utilized.

Funding and Support

By JACEP Open policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The authors have stated that no such relationships exist.

Conflict of Interest

All authors have affirmed they have no conflicts of interest to declare.

Footnotes

Supervising Editor: James Fletcher, MD

Reference

  • 1.Radcliffe C., Gisriel S., Niu Y.S., et al. Pyomyositis and infectious myositis: a comprehensive, single-center retrospective study. Open Forum Infect Dis. 2021;8(4) doi: 10.1093/ofid/ofab098. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of the American College of Emergency Physicians Open are provided here courtesy of American College of Emergency Physicians

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