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. 1991 Jun;176:55–69.

Thyroid morphology and function and its role in thermoregulation in the newborn southern elephant seal (Mirounga leonina) at Macquarie Island.

G J Little 1
PMCID: PMC1260313  PMID: 1917675

Abstract

The thyroid gland of the newborn southern elephant seal pup exhibits markedly increased secretory activity during the first 24 hours after birth. Thyroid epithelial cell height is cuboidal to columnar for pups from birth to 48 hours postpartum after which it decreases by five days of age. Ultrastructurally the thyroid epithelial cells show pseudopodia protruding into the lumen at zero, two and six hours after birth. After 24 hours postpartum pseudopodia are rarely observed in thyroid follicles from two to 20 days old pups. The number of colloid droplets increases by six hours after birth and they are distributed throughout the cytoplasm. At 24 hours and two days, few colloid droplets are observed. Plasma T4 concentration increases three-fold from birth, to peak at six hours postpartum after which it steadily declines. Plasma concentration of T3 increases eight-fold between birth and 24 hours postpartum. T3 levels remain high until five days to seven days, then decrease to 20 days. The observed changes in thyroid epithelial cell height and ultrastructure is strongly suggestive of increased secretion of thyroid hormones during the first six hours of postnatal life. This pattern of thyroid activity is similar to that in other newborn mammals which have been examined. The thyroid gland of the southern elephant seal is markedly active at birth and is responsible for the elevated levels of T4 and T3, thus playing a vital role in maintaining the body temperature of the newborn seal when it enters the harsh environment of the sub-Antarctic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abuid J., Stinson D. A., Larsen P. R. Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J Clin Invest. 1973 May;52(5):1195–1199. doi: 10.1172/JCI107286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andrews J. F., Lynch M., Moore R. E. The early metabolic response of lambs to small doses of 3,3',5-triiodothyronine [proceedings]. J Physiol. 1979 Aug;293:49P–49P. [PubMed] [Google Scholar]
  3. Braverman L. E., Ingbar S. H., Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. J Clin Invest. 1970 May;49(5):855–864. doi: 10.1172/JCI106304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bryden M. M. Growth and function of the subcutaneous fat of the elephant seal. Nature. 1968 Nov 9;220(5167):597–599. doi: 10.1038/220597a0. [DOI] [PubMed] [Google Scholar]
  5. Cabello G. Endocrine reactivity (T3, T4, cortisol) during cold exposure in preterm and full-term lambs. Biol Neonate. 1983;44(4):224–233. doi: 10.1159/000241719. [DOI] [PubMed] [Google Scholar]
  6. Cabello G., Levieux D. Neonatal changes in the concentrations of thyrotropin, triiodothyronine, thyroxine and cortisol in the plasma of pre-term and full-term lambs. J Dev Physiol. 1980 Feb-Apr;2(1-2):59–69. [PubMed] [Google Scholar]
  7. Dobrowolska A., Rewkiewicz-Dziarska A., Szarska I. The effect of exogenic thyroxine on activity of the thyroid gland, blood serum proteins and leukocytes in the common vole Microtus arvalis, Pallas. Comp Biochem Physiol A Comp Physiol. 1976;53(4):323–326. doi: 10.1016/s0300-9629(76)80148-x. [DOI] [PubMed] [Google Scholar]
  8. Engelhardt F. R., Ferguson J. M. Adaptive hormone changes in harp seals, Phoca groenlandica, and gray seals, Halichoerus grypus, during the postnatal period. Gen Comp Endocrinol. 1980 Apr;40(4):434–445. doi: 10.1016/0016-6480(80)90006-4. [DOI] [PubMed] [Google Scholar]
  9. Engström G., Ericson L. E. Effect of graded doses of thyrotropin on exocytosis and early phase of endocytosis in the rat thyroid. Endocrinology. 1981 Feb;108(2):399–405. doi: 10.1210/endo-108-2-399. [DOI] [PubMed] [Google Scholar]
  10. Erenberg A., Phelps D. L., Lam R., Fisher D. A. Total and free thyroid hormone concentrations in the neonatal period. Pediatrics. 1974 Feb;53(2):211–216. [PubMed] [Google Scholar]
  11. Ericson L. E., Engström G. Quantitative electron microscopic studies on exocytosis and endocytosis in the thyroid follicle cell. Endocrinology. 1978 Sep;103(3):883–892. doi: 10.1210/endo-103-3-883. [DOI] [PubMed] [Google Scholar]
  12. Ericson L. E. Exocytosis and endocytosis in the thyroid follicle cell. Mol Cell Endocrinol. 1981 Apr;22(1):1–24. doi: 10.1016/0303-7207(81)90098-8. [DOI] [PubMed] [Google Scholar]
  13. Etling N., Larroche J. C. Histological and biochemical changes in neonatal thyroid tissues. Acta Paediatr Scand. 1975 Mar;64(2):315–321. doi: 10.1111/j.1651-2227.1975.tb03841.x. [DOI] [PubMed] [Google Scholar]
  14. Fisher D. A., Chopra I. J., Dussault J. H. Extrathyroidal conversion of thyroxine to triiodothyronine in sheep. Endocrinology. 1972 Oct;91(4):1141–1144. doi: 10.1210/endo-91-4-1141. [DOI] [PubMed] [Google Scholar]
  15. Frankel S., Lange G. Maturation of hypothalamic-pituitary-thyroid response in the rat to acute cold. Am J Physiol. 1980 Sep;239(3):E223–E226. doi: 10.1152/ajpendo.1980.239.3.E223. [DOI] [PubMed] [Google Scholar]
  16. Fujita H. Fine structure of the thyroid gland. Int Rev Cytol. 1975;40:197–280. doi: 10.1016/s0074-7696(08)60954-7. [DOI] [PubMed] [Google Scholar]
  17. HARRISON R. J., ROWLANDS I. W., WHITTING H. W., YOUNG B. A. Growth and structure of the thyroid gland in the common seal (Phoca vitulina). J Anat. 1962 Jan;96:3–15. [PMC free article] [PubMed] [Google Scholar]
  18. Haidmayer R., Hagmüller K. Influence of ambient temperature on calorigenic action of thyroid hormones in young mice. Pflugers Arch. 1981 Aug;391(2):125–128. doi: 10.1007/BF00657002. [DOI] [PubMed] [Google Scholar]
  19. Jacobsen B. B., Andersen H. J., Peitersen A. B., Dige-Petersen H., Hummer L. Serum levels of thyrotropin, thyroxine and triiodothyronine in fullterm, small-for-gestational age and preterm newborn babies. Acta Paediatr Scand. 1977 Nov;66(6):681–687. doi: 10.1111/j.1651-2227.1977.tb07971.x. [DOI] [PubMed] [Google Scholar]
  20. John T. M., Ronald K., George J. C. Blood levels of thyroid hormones and certain metabolites in relation to moult in the harp seal (Phoca groenlandica). Comp Biochem Physiol A Comp Physiol. 1987;88(4):655–657. doi: 10.1016/0300-9629(87)90678-5. [DOI] [PubMed] [Google Scholar]
  21. Kaciuba-Uscilko H., Legge K. F., Mount L. E. The development of the metabolic response to thyroxine in the new-born pig. J Physiol. 1970 Jan;206(1):229–241. doi: 10.1113/jphysiol.1970.sp009008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Ketelbant-Balasse P., Rodesch F., Neve P., Pasteels J. M. Scanning electron microscope observations of apical surfaces of dog thyroid cells. Exp Eye Res. 1973 Apr;79(1):111–119. [PubMed] [Google Scholar]
  23. Ketelbant-Balasse P., Van Sande J., Neve P., Dumont J. E. Time sequence of 3',5'-cyclic AMP accumulation and ultrastructural changes in dog thyroid slices after acute stimulation by TSH. Horm Metab Res. 1976 May;8(3):212–215. doi: 10.1055/s-0028-1093662. [DOI] [PubMed] [Google Scholar]
  24. Krupp P. P., Lee K. P. Ultrastructure and cytochemistry of thyroid lysosomes following subtotal thyroidectomy. Anat Rec. 1986 Feb;214(2):177–182. doi: 10.1002/ar.1092140212. [DOI] [PubMed] [Google Scholar]
  25. Larroche J. C. Histological structure of the thyroid gland in the newborn. With special reference to hypotrophy, hydrops fetalis and Cesarean section delivery. Biol Neonate. 1976;28(1-2):118–124. doi: 10.1159/000240811. [DOI] [PubMed] [Google Scholar]
  26. Miller K., Irving L. Metabolism and temperature regulation in young harbor seals Phoca vitulina richardi. Am J Physiol. 1975 Aug;229(2):506–511. doi: 10.1152/ajplegacy.1975.229.2.506. [DOI] [PubMed] [Google Scholar]
  27. Moore A. T., Moore R. D., Moore R. E. Latency of thyroid hormone action on heat production in the rat. Experientia Suppl. 1978;32:191–198. doi: 10.1007/978-3-0348-5559-4_21. [DOI] [PubMed] [Google Scholar]
  28. Murakami G., Uchiyama Y. Bimodal variations in subcellular structures of rat thyroid follicular cells during 24 hours: fine structural and morphometric studies. Am J Anat. 1986 Jan;175(1):1–13. doi: 10.1002/aja.1001750102. [DOI] [PubMed] [Google Scholar]
  29. Nève P., Authelet M., Golstein J. Effect of aging on the morphology and function of the thyroid gland of the cream hamster. Further evidence for two different mechanisms of hormone secretion. Cell Tissue Res. 1981;220(3):499–509. doi: 10.1007/BF00216753. [DOI] [PubMed] [Google Scholar]
  30. Parker R. O., Williams P. E., Aherne F. X., Young B. A. Histological structure of the thyroid gland in the neonatal pig. Biol Neonate. 1980;38(3-4):120–125. doi: 10.1159/000241352. [DOI] [PubMed] [Google Scholar]
  31. Parker R. O., Williams P. E., Aherne F. X., Young B. A. Postnatal changes in concentrations of serum and urinary thyroxine and 3,3',5-triiodothyronine in the pig. J Anim Sci. 1980 Jul;51(1):132–137. doi: 10.2527/jas1980.511132x. [DOI] [PubMed] [Google Scholar]
  32. Polk D. H., Wu S. Y., Fisher D. A. Serum thyroid hormones and tissue 5'-monodeiodinase activity in acutely thyroidectomized newborn lambs. Am J Physiol. 1986 Aug;251(2 Pt 1):E151–E155. doi: 10.1152/ajpendo.1986.251.2.E151. [DOI] [PubMed] [Google Scholar]
  33. Roy K. S., Saigal R. P., Nanda B. S., Nagpal S. K. Gross, histomorphological and histochemical changes in thyroid gland of goat with age. IV. Histomorphological study. Anat Anz. 1978;143(1):86–95. [PubMed] [Google Scholar]
  34. Seibel H. R., Knigge K. M. A correlative study of ultrastructure and function of the thyroid gland of the golden hamster. Acta Endocrinol (Copenh) 1972 Feb;69(2):281–297. doi: 10.1530/acta.0.0690281. [DOI] [PubMed] [Google Scholar]
  35. Seljelid R. Endocytosis in thyroid follicle cells. I. Structure and significance of different types of single membrane-limited vacuoles and bodies. J Ultrastruct Res. 1967 Feb;17(3):195–219. doi: 10.1016/s0022-5320(67)80043-1. [DOI] [PubMed] [Google Scholar]
  36. Slebodziński A. B., Nowak G., Zamyslowska H. Sequential observation of changes in thyroxine, triiodothyronine and reverse triiodothyronine during the postnatal adaptation of the pig. Biol Neonate. 1981;39(3-4):191–199. doi: 10.1159/000241436. [DOI] [PubMed] [Google Scholar]
  37. Slebodziński A. Acute depletion of the hormonal-iodine stores from the thyroid gland after birth in lambs. J Endocrinol. 1972 May;53(2):195–200. doi: 10.1677/joe.0.0530195. [DOI] [PubMed] [Google Scholar]
  38. Slebodziński A., Srebro Z. The thyroid gland and the neurosecretory activity of the hypothalamus in the newborn rabbit. J Endocrinol. 1968 Oct;42(2):193–203. doi: 10.1677/joe.0.0420193. [DOI] [PubMed] [Google Scholar]
  39. Strbák V., Macho L., Skultétyová M., Michalicková J. Thyroid activity in early weaned and suckling infants and their lactating mothers. Endocrinol Exp. 1978 Jun;12(2):103–107. [PubMed] [Google Scholar]
  40. Uchiyama Y., Murakami G., Igarashi M. Changes in colloid droplets and dense bodies in rat thyroid follicular cells during 24 hours: fine structural and morphometric studies. Am J Anat. 1986 Jan;175(1):15–22. doi: 10.1002/aja.1001750103. [DOI] [PubMed] [Google Scholar]
  41. Wrutniak C., Cabello G. Neonatal changes in plasma cortisol, free and total iodothyronine levels in control and hypotrophic lambs. Reprod Nutr Dev. 1987;27(5):945–953. doi: 10.1051/rnd:19870707. [DOI] [PubMed] [Google Scholar]
  42. Wynn P. C., Wallace A. L., Kirby A. C., Annison E. F. Effects of growth hormone administration on wool growth in merino sheep. Aust J Biol Sci. 1988;41(2):177–187. doi: 10.1071/bi9880177. [DOI] [PubMed] [Google Scholar]

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