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. 1992 Apr;62(1):8–9. doi: 10.1016/S0006-3495(92)81761-7

Mapping hydrophobic residues of the interaction surface of charybdotoxin.

P Stampe 1, L Kolmakova-Partensky 1, C Miller 1
PMCID: PMC1260467  PMID: 1376176

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson C. S., MacKinnon R., Smith C., Miller C. Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol. 1988 Mar;91(3):317–333. doi: 10.1085/jgp.91.3.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bontems F., Roumestand C., Boyot P., Gilquin B., Doljansky Y., Menez A., Toma F. Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins. Eur J Biochem. 1991 Feb 26;196(1):19–28. doi: 10.1111/j.1432-1033.1991.tb15780.x. [DOI] [PubMed] [Google Scholar]
  3. Lucchesi K., Ravindran A., Young H., Moczydlowski E. Analysis of the blocking activity of charybdotoxin homologs and iodinated derivatives against Ca2+-activated K+ channels. J Membr Biol. 1989 Aug;109(3):269–281. doi: 10.1007/BF01870284. [DOI] [PubMed] [Google Scholar]
  4. MacKinnon R., Miller C. Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol. 1988 Mar;91(3):335–349. doi: 10.1085/jgp.91.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Miller C., Moczydlowski E., Latorre R., Phillips M. Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature. 1985 Jan 24;313(6000):316–318. doi: 10.1038/313316a0. [DOI] [PubMed] [Google Scholar]
  6. Park C. S., Hausdorff S. F., Miller C. Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2046–2050. doi: 10.1073/pnas.88.6.2046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Reinhart P. H., Chung S., Levitan I. B. A family of calcium-dependent potassium channels from rat brain. Neuron. 1989 Jan;2(1):1031–1041. doi: 10.1016/0896-6273(89)90227-4. [DOI] [PubMed] [Google Scholar]
  8. Smith C., Phillips M., Miller C. Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel. J Biol Chem. 1986 Nov 5;261(31):14607–14613. [PubMed] [Google Scholar]

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