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. 1986 Aug;147:115–119.

Parasympathetic innervation of the thymus: a histochemical and immunocytochemical study.

J A Fatani 1, M A Qayyum 1, L Mehta 1, U Singh 1
PMCID: PMC1261551  PMID: 3319996

Abstract

The presence of parasympathetic nerve supply to the thymus has been demonstrated by histochemical and immunocytochemical methods using antibodies against cholineacetyl transferase. Fine nerve fibres have been observed both in the thymic parenchyma and around the blood vessels. The role of the parasympathetic nerve supply to the thymus is briefly discussed.

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Selected References

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  1. Besedovsky H. O., del Rey A., Sorkin E., Da Prada M., Keller H. H. Immunoregulation mediated by the sympathetic nervous system. Cell Immunol. 1979 Dec;48(2):346–355. doi: 10.1016/0008-8749(79)90129-1. [DOI] [PubMed] [Google Scholar]
  2. Bulloch K., Moore R. Y. Innervation of the thymus gland by brain stem and spinal cord in mouse and rat. Am J Anat. 1981 Oct;162(2):157–166. doi: 10.1002/aja.1001620207. [DOI] [PubMed] [Google Scholar]
  3. Fillenz M. The innervation of the cat spleen. Proc R Soc Lond B Biol Sci. 1970 Jan 20;174(1037):459–468. doi: 10.1098/rspb.1970.0005. [DOI] [PubMed] [Google Scholar]
  4. Fujiwara M., Muryobayashi T., Shimamoto K. Histochemical demonstration of monoamines in the thymus of rats. Jpn J Pharmacol. 1966 Dec;16(4):493–494. doi: 10.1254/jjp.16.493. [DOI] [PubMed] [Google Scholar]
  5. KARNOVSKY M. J., ROOTS L. A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem. 1964 Mar;12:219–221. doi: 10.1177/12.3.219. [DOI] [PubMed] [Google Scholar]
  6. Qayyum M. A., Fatani J. A. Use of glyoxylic acid in the demonstration of autonomic nerve profiles. Experientia. 1985 Nov 15;41(11):1389–1390. doi: 10.1007/BF01949999. [DOI] [PubMed] [Google Scholar]
  7. Raimond F., Morel E., Bach J. F. Evidence for the presence of immunoreactive acetylcholine receptors on human thymus cells. J Neuroimmunol. 1984 Feb;6(1):31–40. doi: 10.1016/0165-5728(84)90040-7. [DOI] [PubMed] [Google Scholar]
  8. Reilly F. D., McCuskey R. S., Meineke H. A. Studies of the hemopoietic microenvironment. VIII. Andrenergic and cholinergic innervation of the murine spleen. Anat Rec. 1976 May;185(1):109–117. doi: 10.1002/ar.1091850111. [DOI] [PubMed] [Google Scholar]
  9. Sergeeva V. E. Histotopography of catecholamines in the mammalian thymus. Bull Exp Biol Med. 1974 Oct;77(4):456–458. doi: 10.1007/BF00798115. [DOI] [PubMed] [Google Scholar]
  10. Singh U. Effect of catecholamines on lymphopoiesis in fetal mouse thymic explants. J Anat. 1979 Sep;129(Pt 2):279–292. [PMC free article] [PubMed] [Google Scholar]
  11. Singh U. Effect of sympathectomy on the maturation of fetal thymocytes grown within the anterior eye chambers in mice. Adv Exp Med Biol. 1985;186:349–356. doi: 10.1007/978-1-4613-2463-8_42. [DOI] [PubMed] [Google Scholar]
  12. Singh U., Millson D. S., Smith P. A., Owen J. J. Identification of beta adrenoreceptors during thymocyte ontogeny in mice. Eur J Immunol. 1979 Jan;9(1):31–35. doi: 10.1002/eji.1830090108. [DOI] [PubMed] [Google Scholar]
  13. Singh U. Sympathetic innervation of fetal mouse thymus. Eur J Immunol. 1984 Aug;14(8):757–759. doi: 10.1002/eji.1830140817. [DOI] [PubMed] [Google Scholar]
  14. Strom T. B., Lundin A. P., Carpenter C. B. The role of cyclic nucleotides in lymphocyte activation and function. Prog Clin Immunol. 1977;3:115–153. [PubMed] [Google Scholar]
  15. Strom T. B., Sytkowski A. J., Carpenter C. B., Merrill J. P. Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1330–1333. doi: 10.1073/pnas.71.4.1330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Walcott B., McLean J. R. Catecholamine-containing neurons and lymphoid cells in a lacrimal gland of the pigeon. Brain Res. 1985 Feb 25;328(1):129–137. doi: 10.1016/0006-8993(85)91331-9. [DOI] [PubMed] [Google Scholar]
  17. Williams J. M., Peterson R. G., Shea P. A., Schmedtje J. F., Bauer D. C., Felten D. L. Sympathetic innervation of murine thymus and spleen: evidence for a functional link between the nervous and immune systems. Brain Res Bull. 1981 Jan;6(1):83–94. doi: 10.1016/s0361-9230(81)80072-x. [DOI] [PubMed] [Google Scholar]

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