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. 1987 Feb;150:277–286.

The development of Schmidt-Lanterman incisures: an electron microscope study.

J R Small 1, M N Ghabriel 1, G Allt 1
PMCID: PMC1261681  PMID: 3654340

Abstract

The development of Schmidt-Lanterman incisures was investigated in the rat sural nerve during an active phase of postnatal myelination (5-21 days post partum). Two distinct populations of incisures were recognised and the following nomenclature for their developmental stages is proposed. Primary incisures which appear ab initio in myelination and always extend across the whole radial thickness of the myelin sheath but initially around only part of its circumference. Consequently they appear in transverse section as sectoral incisures (occupying less than half the circumference) and in longitudinal section as asymmetric incisures (involving one side only of the myelin sheath). Secondary incisures appear later, in regions of a compact myelin sheath, initially traversing only part of its radial thickness but commonly occupying its whole circumference. Thus they usually appear in transverse section as circumferential incisures and in longitudinal section as symmetric incisures (involving both sides of the myelin sheath). Less commonly secondary incisures may form in a sector of the myelin sheath but still in regions of compact myelin and thus appear asymmetric in longitudinal section and sectoral in transverse section. Secondary incisures appear mainly adaxonally in the earlier stages examined and mainly abaxonally in the later stages. The maturation of primary and secondary incisures into the radially and circumferentially complete incisure characteristic of the mature myelinated nerve fibre is described. The above mechanisms of incisural formation are contrasted with mechanisms previously suggested to occur during normal development and remyelination and related to the plasticity and ultrastructure of the myelin sheath.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blakemore W. F. Schmidt-Lantermann incisures in the central nervous system. J Ultrastruct Res. 1969 Dec;29(5):496–498. doi: 10.1016/s0022-5320(69)90069-0. [DOI] [PubMed] [Google Scholar]
  2. Cooper N. A., Kidman A. D. Quantitation of the Schmidt-Lanterman incisures in juvenile, adult, remyelinated and regenerated fibres of the chicken sciatic nerve. Acta Neuropathol. 1984;64(3):251–258. doi: 10.1007/BF00688116. [DOI] [PubMed] [Google Scholar]
  3. Friede R. L., Samorajski T. The clefts of Schmidt-Lantermann: a quantitative electron microscopic study of their structure in developing and adult sciatic nerves of the rat. Anat Rec. 1969 Sep;165(1):89–101. doi: 10.1002/ar.1091650110. [DOI] [PubMed] [Google Scholar]
  4. Ghabriel M. N., Allt G. Incisures of Schmidt-Lanterman. Prog Neurobiol. 1981;17(1-2):25–58. doi: 10.1016/0301-0082(81)90003-4. [DOI] [PubMed] [Google Scholar]
  5. Ghabriel M. N., Allt G. Schmidt-Lanterman Incisures. I. A quantitative teased fibre study of remyelinating peripheral nerve fibres. Acta Neuropathol. 1980;52(2):85–95. doi: 10.1007/BF00688005. [DOI] [PubMed] [Google Scholar]
  6. Ghabriel M. N., Allt G. Schmidt-Lanterman incisures. II. A light and electron microscope study of remyelinating peripheral nerve fibres. Acta Neuropathol. 1980;52(2):97–104. doi: 10.1007/BF00688006. [DOI] [PubMed] [Google Scholar]
  7. Ghabriel M. N., Allt G. The role of Schmidt-Lanterman incisures in Wallerian degeneration. II. An electron microscopic study. Acta Neuropathol. 1979 Nov;48(2):95–103. doi: 10.1007/BF00691150. [DOI] [PubMed] [Google Scholar]
  8. Hall S. M., Gregson N. A. The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse. J Cell Sci. 1971 Nov;9(3):769–789. doi: 10.1242/jcs.9.3.769. [DOI] [PubMed] [Google Scholar]
  9. Hall S. M. Some aspects of remyelination after demyelination produced by the intraneural injection of lysophosphatidyl choline. J Cell Sci. 1973 Sep;13(2):461–477. doi: 10.1242/jcs.13.2.461. [DOI] [PubMed] [Google Scholar]
  10. Hall S. M., Williams P. L. Studies on the "incisures" of Schmidt and Lanterman. J Cell Sci. 1970 May;6(3):767–791. doi: 10.1242/jcs.6.3.767. [DOI] [PubMed] [Google Scholar]
  11. ROBERTSON J. D. The ultrastructure of Schmidt-Lanterman clefts and related shearing defects of the myelin sheath. J Biophys Biochem Cytol. 1958 Jan 25;4(1):39–46. doi: 10.1083/jcb.4.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WEBSTER H. F. THE RELATIONSHIP BETWEEN SCHMIDT-LANTERMANN INCISURES AND MYELIN SEGMENTATION DURING WALLERIAN DEGENERATION. Ann N Y Acad Sci. 1965 Mar 31;122:29–38. doi: 10.1111/j.1749-6632.1965.tb20189.x. [DOI] [PubMed] [Google Scholar]
  13. WEBSTERHDE F. SOME ULTRASTRUCTURAL FEATURES OF SEGMENTAL DEMYELINATION AND MYELIN REGENERATION IN PERIPHERAL NERVE. Prog Brain Res. 1964;13:151–174. [PubMed] [Google Scholar]
  14. Williams P. L., Hall S. M. Chronic Wallerian degeneration--an in vivo and ultrastructural study. J Anat. 1971 Sep;109(Pt 3):487–503. [PMC free article] [PubMed] [Google Scholar]
  15. Williams P. L., Hall S. M. Prolonged in vivo observations of normal peripheral nerve fibres and their acute reactions to crush and deliberate trauma. J Anat. 1971 Apr;108(Pt 3):397–408. [PMC free article] [PubMed] [Google Scholar]
  16. Wiśniewski H., Raine C. S. An ultrastructural study of experimental demyelination and remyelination. V. Central and peripheral nervous system lesions caused by diphtheria toxin. Lab Invest. 1971 Jul;25(1):73–80. [PubMed] [Google Scholar]

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