Abstract
Examination of congenitally fused (blocked) vertebrae in this study suggests that non-development of the joint between articular facets results in fusion of the vertebral arches which in turn leads to secondary fusion of the bodies and hypoplasia of the intervertebral discs. The presence of independent pedicles and transverse processes do not favour the concept that such an abnormality is the result of non-segmentation of the sclerotome. The condition is probably linked to a defect of an inductor substance which influences normal morphogenesis of the vertebral arch in the embryonic period.
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- Barclay-Smith E. Multiple Anomaly in a Vertebral Column. J Anat Physiol. 1911 Jan;45(Pt 2):144–171. [PMC free article] [PubMed] [Google Scholar]
- FRANCIS C. C. Certain changes in the aged male white cervical spine. Anat Rec. 1956 Aug;125(4):783–787. doi: 10.1002/ar.1091250411. [DOI] [PubMed] [Google Scholar]
- FRANCIS C. C. Variations in the articular facets of the cervical vertebrae. Anat Rec. 1955 Aug;122(4):589–602. doi: 10.1002/ar.1091220408. [DOI] [PubMed] [Google Scholar]
- GRAY S. W., ROMAINE C. B., SKANDALAKIS J. E. CONGENITAL FUSION OF THE CERVICAL VERTEBRAE. Surg Gynecol Obstet. 1964 Feb;118:373–385. [PubMed] [Google Scholar]
- GROBSTEIN C., PARKER G. In vitro induction of cartilage in mouse somite mesoderm by embryonic spinal cord. Proc Soc Exp Biol Med. 1954 Mar;85(3):477–481. doi: 10.3181/00379727-85-20924. [DOI] [PubMed] [Google Scholar]
- Glenister T. W. An embryological view of cartilage. J Anat. 1976 Nov;122(Pt 2):323–330. [PMC free article] [PubMed] [Google Scholar]
- Gunderson C. H., Greenspan R. H., Glaser G. H., Lubs H. A. The Klippel-Feil syndrome: genetic and clinical reevaluation of cervical fusion. Medicine (Baltimore) 1967 Nov;46(6):491–512. doi: 10.1097/00005792-196711000-00003. [DOI] [PubMed] [Google Scholar]
- Kosher R. A. Inhibition of "spontaneous," notochord-induced, and collagen-induced in vitro somite chondrogenesis by cyclic AMP derivatives and theophylline. Dev Biol. 1976 Oct 15;53(2):265–276. doi: 10.1016/0012-1606(76)90228-1. [DOI] [PubMed] [Google Scholar]
- Lipton B. H., Jacobson A. G. Analysis of normal somite development. Dev Biol. 1974 May;38(1):73–90. doi: 10.1016/0012-1606(74)90260-7. [DOI] [PubMed] [Google Scholar]
- McMaster M. J., Ohtsuka K. The natural history of congenital scoliosis. A study of two hundred and fifty-one patients. J Bone Joint Surg Am. 1982 Oct;64(8):1128–1147. [PubMed] [Google Scholar]
- Minor R. R. Somite chondrogenesis. A structural analysis. J Cell Biol. 1973 Jan;56(1):27–50. doi: 10.1083/jcb.56.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Verbout A. J. A critical review of the 'neugliederung' concept in relation to the development of the vertebral column. Acta Biotheor. 1976;25(4):219–258. doi: 10.1007/BF00046818. [DOI] [PubMed] [Google Scholar]
- Verbout A. J. The development of the vertebral column. Adv Anat Embryol Cell Biol. 1985;90:1–122. doi: 10.1007/978-3-642-69983-2. [DOI] [PubMed] [Google Scholar]
- WALMSLEY R. The development and growth of the intervertebral disc. Edinb Med J. 1953 Aug;60(8):341–364. [PMC free article] [PubMed] [Google Scholar]
- WATTERSON R. L., FOWLER I., FOWLER B. J. The role of the neural tube and notochord in development of the axial skeleton of the chick. Am J Anat. 1954 Nov;95(3):337–399. doi: 10.1002/aja.1000950302. [DOI] [PubMed] [Google Scholar]
- Wyburn G. M. Observations on the development of the human vertebral column. J Anat. 1944 Apr;78(Pt 3):94–102.2. [PMC free article] [PubMed] [Google Scholar]