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. 1988 Aug;159:73–82.

Blood flow to the rat rectum: its intramural distribution and the response to injury.

R A Sparrow 1, H M Connolly 1
PMCID: PMC1262010  PMID: 3248974

Abstract

Rectal blood flow was measured in rats using radioactive microspheres. Subsequent sectioning of the material allowed the intramural distribution of that flow to be assessed. Total flow increased with increasing distance from the anorectal junction but the distribution of flow remained the same with the mucosa receiving slightly less than two thirds of the total. Injury to the mucosa, produced by a surfactant administered as a suppository, doubled total flow in areas where the damage was most severe and revealed an ability of the intramural vascular beds to react independently. Flow to the mucosa increased both absolutely and proportionately and this entirely accounted for the increase in total flow. Flow to the muscularis externa was unaltered in absolute terms, but fell as a percentage of total flow.

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Selected References

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  1. Andersson P. O., Bloom S. R., Edwards A. V., Järhult J., Mellander S. Neural vasodilator control in the rectum of the cat and its possible mediation by vasoactive intestinal polypeptide. J Physiol. 1983 Nov;344:49–67. doi: 10.1113/jphysiol.1983.sp014923. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andersson P. O. Vascular control in the colon and rectum. Scand J Gastroenterol Suppl. 1984;93:65–78. [PubMed] [Google Scholar]
  3. Barrowman J. A., Kvietys P. R., Granger D. N., McElearney P. M., Perry M. A. Effects of the constituents of a corticosteroid enema preparation on colonic blood flow and oxygen uptake in the dog. J Pharmacol Exp Ther. 1983 Jul;226(1):217–221. [PubMed] [Google Scholar]
  4. Bohlen H. G., Henrich H., Gore R. W., Johnson P. C. Intestinal muscle and mucosal blood flow during direct sympathetic stimulation. Am J Physiol. 1978 Jul;235(1):H40–H45. doi: 10.1152/ajpheart.1978.235.1.H40. [DOI] [PubMed] [Google Scholar]
  5. Bond J. H., Levitt M. D. Effect of glucagon on gastrointestinal blood flow of dogs in hypovolemic shock. Am J Physiol. 1980 May;238(5):G434–G439. doi: 10.1152/ajpgi.1980.238.5.G434. [DOI] [PubMed] [Google Scholar]
  6. Brown J. A., Zipser R. D. Prostaglandin regulation of colonic blood flow in rabbit colitis. Gastroenterology. 1987 Jan;92(1):54–59. doi: 10.1016/0016-5085(87)90839-0. [DOI] [PubMed] [Google Scholar]
  7. Browning J., Gannon B. Mucosal microvascular organization of the rat colon. Acta Anat (Basel) 1986;126(2):73–77. doi: 10.1159/000146191. [DOI] [PubMed] [Google Scholar]
  8. Dinda P. K., Buell M. G., DaCosta L. R., Beck I. T. Simultaneous estimation of arteriolar, capillary, and shunt blood flow of the gut mucosa. Am J Physiol. 1983 Jul;245(1):G29–G37. doi: 10.1152/ajpgi.1983.245.1.G29. [DOI] [PubMed] [Google Scholar]
  9. Folkow B. Regional adjustments of intestinal blood flow. Gastroenterology. 1967 Feb;52(2):423–432. [PubMed] [Google Scholar]
  10. Grandison A. S., Yates J., Shields R. Capillary blood flow in the canine colon and other organs at normal and raised portal pressure. Gut. 1981 Mar;22(3):223–227. doi: 10.1136/gut.22.3.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Greenway C. V., Murthy V. S. Effects of vasopressin and isoprenaline infusions on the distribution of blod flow in the intestine; criteria for the validity of microsphere studies. Br J Pharmacol. 1972 Oct;46(2):117–188. doi: 10.1111/j.1476-5381.1972.tb06863.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hamilton S. R. Structure of the colon. Scand J Gastroenterol Suppl. 1984;93:13–23. [PubMed] [Google Scholar]
  13. Heymann M. A., Payne B. D., Hoffman J. I., Rudolph A. M. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977 Jul-Aug;20(1):55–79. doi: 10.1016/s0033-0620(77)80005-4. [DOI] [PubMed] [Google Scholar]
  14. Holyhead E. M., Thomas N. W., Wilson C. G. The regeneration of rectal epithelium in the rat following wounding with suppositories of polyoxyethylene (23) lauryl ether. Br J Exp Pathol. 1983 Aug;64(4):456–461. [PMC free article] [PubMed] [Google Scholar]
  15. Kvietys P. R., Granger D. N. Regulation of colonic blood flow. Fed Proc. 1982 Apr;41(6):2106–2110. [PubMed] [Google Scholar]
  16. Maxwell L. C., Shepherd A. P., Riedel G. L., Morris M. D. Effect of microsphere size on apparent intramural distribution of intestinal blood flow. Am J Physiol. 1981 Sep;241(3):H408–H414. doi: 10.1152/ajpheart.1981.241.3.H408. [DOI] [PubMed] [Google Scholar]
  17. Sparrow R. A., Coupland R. E. Blood flow to the adrenal gland of the rat: its distribution between the cortex and the medulla before and after haemorrhage. J Anat. 1987 Dec;155:51–61. [PMC free article] [PubMed] [Google Scholar]
  18. Tuma R. F., Vasthare U. S., Irion G. L., Wiedeman M. P. Considerations in use of microspheres for flow measurements in anesthetized rat. Am J Physiol. 1986 Jan;250(1 Pt 2):H137–H143. doi: 10.1152/ajpheart.1986.250.1.H137. [DOI] [PubMed] [Google Scholar]
  19. Varhaug J. E., Svanes K., Svanes C., Lekven J. Gastric blood flow determination: intramural distribution and arteriovenous shunting of microspheres. Am J Physiol. 1984 Nov;247(5 Pt 1):G468–G479. doi: 10.1152/ajpgi.1984.247.5.G468. [DOI] [PubMed] [Google Scholar]

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