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. 1992 Aug;63(2):485–496. doi: 10.1016/S0006-3495(92)81628-4

Conformational model for ion permeation in membrane channels: a comparison with multi-ion models and applications to calcium channel permeability.

S L Mironov 1
PMCID: PMC1262172  PMID: 1384738

Abstract

The permeation properties of ion channels existing in several conductive states were analyzed. Each state was represented by the one-ion model. A special emphasis was placed on features, assumed to be indicative of a multi-ion mode of channel occupancy such as a deviation of concentration dependence of channel conductance from the Michaelis-Menten equation, an anomalous mole fraction effect, a strong voltage dependence of ion block and coupling of unidirectional fluxes (anomalous Ussing flux ratio). The conformational model was shown to have all these properties. The ion permeation through voltage-sensitive calcium channels fulfilled all the characteristics of the model proposed.

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Selected References

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