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. 2025 Nov 19;12:1840. doi: 10.1038/s41597-025-06136-9

Table 2.

Comparison of Ro5 properties across PROTAC databases.

Property PROTAC-PatentDB ARVINAS-DB PROTAC-DB 1.0 PROTACpedia
Count 63,136 1,573 9,380 1,202
MW Mean 920.7 <950 939.7 1,000.1
Max 3,487.5 / 2,750.3 1,963.2
Min 444.3 / 409.4 382.3
cLogP Mean 3.8 1–7 5.0 5.7
Max 15.0 / 19.2 14.4
Min −5.0 / −18.0 −3.0
HBA Mean 16.0 <15 17.7 14.3
Max RDKIT / / /
Min RDKIT / / /
HBD Mean 3.6 <2 4.5 4.4
Max RDKIT / / /
Min RDKIT / / /
TPSA Mean 192.5 <200 240.0 227.2
Max 1,072.9 / / 460.0
Min 34.3 / / 98.9