There was a mistake in Table 7 as published. The phases corresponding to NCT06751966 and NCT06751914 were omitted. The corrected Table 7 appears below.
Table 7.
Clinical trials based on neoantigen vaccines for the treatment of colorectal cancer.
| ClinicalTrials.Gov identifier | Combinatorial agent(s) | Phase | Primary endpoint | Status |
|---|---|---|---|---|
| NCT03948763 | Pembrolizumab | Phase 1 | DLTs | Terminated |
| NCT06195384 | Phase 1 | Safety | Recruiting | |
| NCT06496373 | Phase 1 | Reaction of antigen-specific T cells | Recruiting | |
| NCT05359354 | Not Applicable | MTD,DLTs | Recruiting | |
| NCT05916248 | Pembrolizumab | Phase 1 | MTD,DLTs,ORR,DCR | Recruiting |
| NCT05940181 | Sintilimab | Interventional | MTD,DLTs,Safety | Recruiting |
| NCT06497010 | Phase 1 | RP2D | Recruiting | |
| NCT03639714 | Nivolumab;Ipilimumab | Phase 1,2 | TEAEs,DLTs,ORR, RP2D | Completed |
| NCT06751966 | Not Applicable | ORR,DCR,Safety | Recruiting | |
| NCT06751914 | Not Applicable | ORR,DCR,Safety | Recruiting | |
| NCT04147078 | Phase 1 | DFS | Recruiting | |
| NCT04117087 | Nivolumab;Ipilimumab | Phase 1 | Safety,Fold change in CD8 and CD4 T cells | Recruiting |
| NCT02600949 | Phase 1 | Feasibility,TEAEs | Recruiting | |
| NCT03552718 | Phase 1 | Safety,RP2D | Active | |
| NCT04041310 | Pembrolizumab | Phase 1,2 | DLTs,ORR,Safety, Tolerability |
Active |
| NCT03953235 | Nivolumab;Ipilimumab | Phase 1,2 | TEAEs,DLTs, ORR, RP2D |
Completed |
| NCT04912765 | Nivolumab | Phase 2 | PFS | Recruiting |
| NCT06522919 | Pembrolizumab | Phase 2 | ORR,PFS | Recruiting |
| NCT05141721 | Atezolizumab;Fluoropyrimidine;Bevacizumab;Ipilimumab | Phase 2,3 | ctDNA,PFS | Active |
The original version of this article has been updated.
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