Skip to main content
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1992 Jan;56(1):78–80.

Seroconversion of pigs in contact with dogs exposed to canine coronavirus.

R D Woods 1, R D Wesley 1
PMCID: PMC1263508  PMID: 1316800

Abstract

In order to determine if canine coronavirus (CCV) could be transmitted to pigs, two dogs were inoculated orally with virulent CCV. After 24 h, the dogs were moved to an isolation room that contained three three-day-old pigs. A wire mesh fence, allowing close contact between the animals, separated the dogs from the pigs. The dogs and pigs were observed for 14 days for clinical signs of disease. Samples of blood were obtained from dogs and pigs immediately before the dogs were inoculated with virus and 14 and 28 days later. The dogs developed mild clinical signs of an infection, but the pigs remained normal throughout the observation period. The dogs shed CCV for eight days after exposure. All three pigs developed neutralizing antibodies against CCV and transmissible gastroenteritis virus by 14 days after they were exposed to the dogs.

Full text

PDF
78

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bae I., Jackwood D. J., Benfield D. A., Saif L. J., Wesley R. D., Hill H. Differentiation of transmissible gastroenteritis virus from porcine respiratory coronavirus and other antigenically related coronaviruses by using cDNA probes specific for the 5' region of the S glycoprotein gene. J Clin Microbiol. 1991 Jan;29(1):215–218. doi: 10.1128/jcm.29.1.215-218.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Binn L. N., Lazar E. C., Keenan K. P., Huxsoll D. L., Marchwicki R. H., Strano A. J. Recovery and characterization of a coronavirus from military dogs with diarrhea. Proc Annu Meet U S Anim Health Assoc. 1974;(78):359–366. [PubMed] [Google Scholar]
  3. Callebaut P., Pensaert M. B., Hooyberghs J. A competitive inhibition ELISA for the differentiation of serum antibodies from pigs infected with transmissible gastroenteritis virus (TGEV) or with the TGEV-related porcine respiratory coronavirus. Vet Microbiol. 1989 May;20(1):9–19. doi: 10.1016/0378-1135(89)90003-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Horzinek M. C., Lutz H., Pedersen N. C. Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronaviruses. Infect Immun. 1982 Sep;37(3):1148–1155. doi: 10.1128/iai.37.3.1148-1155.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kemeny L. J. Isolation of transmissible gastroenteritis virus from pharyngeal swabs obtained from sows at slaughter. Am J Vet Res. 1978 Apr;39(4):703–705. [PubMed] [Google Scholar]
  6. McClurkin A. W., Stark S. L., Norman J. O. Transmissible gastroenteritis (TGE) of swine: the possible role of dogs in the epizootiology of TGE. Can J Comp Med. 1970 Oct;34(4):347–349. [PMC free article] [PubMed] [Google Scholar]
  7. Norman J. O., McClurkin A. W., Stark S. L. Transmissible gastroenteritis (TGE) of swine: canine serum antibodies against an associated virus. Can J Comp Med. 1970 Apr;34(2):115–117. [PMC free article] [PubMed] [Google Scholar]
  8. Pedersen N. C., Ward J., Mengeling W. L. Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species. Arch Virol. 1978;58(1):45–53. doi: 10.1007/BF01315534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pensaert M., Callebaut P., Vergote J. Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis. Vet Q. 1986 Jul;8(3):257–261. doi: 10.1080/01652176.1986.9694050. [DOI] [PubMed] [Google Scholar]
  10. Wesley R. D., Wesley I. V., Woods R. D. Differentiation between transmissible gastroenteritis virus and porcine respiratory coronavirus using a cDNA probe. J Vet Diagn Invest. 1991 Jan;3(1):29–32. doi: 10.1177/104063879100300106. [DOI] [PubMed] [Google Scholar]
  11. Woods R. D., Cheville N. F., Gallagher J. E. Lesions in the small intestine of newborn pigs inoculated with porcine, feline, and canine coronaviruses. Am J Vet Res. 1981 Jul;42(7):1163–1169. [PubMed] [Google Scholar]
  12. Woods R. D., Wesley R. D. Immune response in sows given transmissible gastroenteritis virus or canine coronavirus. Am J Vet Res. 1986 Jun;47(6):1239–1242. [PubMed] [Google Scholar]
  13. Woods R. D., Wesley R. D., Kapke P. A. Neutralization of porcine transmissible gastroenteritis virus by complement-dependent monoclonal antibodies. Am J Vet Res. 1988 Mar;49(3):300–304. [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES