Abstract
Five ewes were injected with two doses of a nonsteroidal anti-inflammatory drug (NSAI), lysine acetyl salicylate, at birth of their first lamb and one hour later, and five others were injected once only, at birth of their first lamb. A control group of six animals was constituted. The times needed for fetal expulsion and placental release were recorded. The peripheral plasma PgF2 alpha (as PGFM) levels were measured prepartum during the seven last days of gestation, at parturition, then 1 h, 2 h and 12 h after lambing. The results were compared among and within treatment groups. They indicate that the physiological increase in peripheral PGFM levels starts two days before lambing and that the level peaks at lambing. The normal decrease after parturition is emphasized by NSAI injections as detected 1 h and 2 h posttreatment (p < 0.01). The NSAI drug is short-acting as revealed by the lower PGFM levels in twice-treated animals 2 h after birth compared to once treated animals and the similar low levels in all three groups 12 h after birth. The fetal membranes were expelled normally in all treated and nontreated animals, but the time needed for placental expulsion in ewes injected with two doses of NSAI was longer than in controls (p < 0.05). A negative correlation (p < 0.05) was found between plasma PGFM levels measured two hours after lambing and the time needed for fetal membrane expulsion. PgF2 alpha appears to have a role in placental release in the ewe.
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- Aiumlamai S., Fredriksson G., Uggla A., Kindahl H., Edqvist L. E. The effect of Toxoplasma gondii infection in flunixin meglumine treated pregnant ewes as monitored by plasma levels of 15-ketodihydroprostaglandin F2 alpha, progesterone, oestrone sulphate and ultrasound scanning. Zentralbl Veterinarmed A. 1990 Feb;37(1):23–34. doi: 10.1111/j.1439-0442.1990.tb00872.x. [DOI] [PubMed] [Google Scholar]
- Basu S. Endogenous inhibition of arachidonic acid metabolism in the endometrium of the sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Mar;35(3):147–152. doi: 10.1016/0952-3278(89)90116-6. [DOI] [PubMed] [Google Scholar]
- Edqvist L. E., Lindell J. O., Kindahl H. Prostaglandin F2 alpha release at premature and normal term deliveries in the cow. Acta Vet Scand Suppl. 1981;77:267–277. [PubMed] [Google Scholar]
- Erwich J. J., Joosten I., Hovius J., Keirse M. J. Prostaglandin catabolism in the bovine placenta. Placenta. 1988 May-Jun;9(3):297–302. doi: 10.1016/0143-4004(88)90037-9. [DOI] [PubMed] [Google Scholar]
- Evans C. A., Kennedy T. G., Patrick J. E., Challis J. R. The effects of indomethacin on uterine activity and prostaglandin (PG) concentrations during labor induced by administering ACTH to fetal sheep. Can J Physiol Pharmacol. 1982 Sep;60(9):1200–1209. doi: 10.1139/y82-174. [DOI] [PubMed] [Google Scholar]
- Fairclough R. J., Hunter J. T., Welch R. A. Peripheral plasma progesterone and utero-ovarian prostaglandin F concentrations in the cow around parturition. Prostaglandins. 1975 Jun;9(6):901–914. doi: 10.1016/0090-6980(75)90078-7. [DOI] [PubMed] [Google Scholar]
- Flint A. P., Anderson A. B., Patten P. T., Turnbull A. C. Control of utero-ovarian venous prostaglandin F during labour in the sheep: acute effects of vaginal and cervical stimulation. J Endocrinol. 1974 Oct;63(1):67–87. doi: 10.1677/joe.0.0630067. [DOI] [PubMed] [Google Scholar]
- Fredriksson G. Release of PGF(2alpha) during parturition and the postpartum period in the ewe. Theriogenology. 1985 Sep;24(3):331–335. doi: 10.1016/0093-691x(85)90224-9. [DOI] [PubMed] [Google Scholar]
- Horta A. E., Chassagne M., Brochart M. Prostaglandin F2 alpha and prostacyclin imbalance in cows with placental retention: new findings. Ann Rech Vet. 1986;17(4):395–400. [PubMed] [Google Scholar]
- Izhar M., Pasmanik M., Marcus S., Shemesh M. Dexamethasone inhibition of cyclooxygenase expression in bovine term placenta. Prostaglandins. 1992 Mar;43(3):239–254. doi: 10.1016/0090-6980(92)90092-8. [DOI] [PubMed] [Google Scholar]
- Leidl W., Hegner D., Rockel Investigations on the PGF2a concentration in maternal and foetal cotyledons of cows with and without retained foetal membranes. Zentralbl Veterinarmed A. 1980;27(9-10):691–696. doi: 10.1111/j.1439-0442.1980.tb02019.x. [DOI] [PubMed] [Google Scholar]
- Olson D. M., Lye S. J., Skinner K., Challis J. R. Prostanoid concentrations in maternal/fetal plasma and amniotic fluid and intrauterine tissue prostanoid output in relation to myometrial contractility during the onset of adrenocorticotropin-induced preterm labor in sheep. Endocrinology. 1985 Jan;116(1):389–397. doi: 10.1210/endo-116-1-389. [DOI] [PubMed] [Google Scholar]
- Perry J. S., Heap R. B., Ackland N. The ultrastructure of the sheep placenta around the time of parturition. J Anat. 1975 Dec;120(Pt 3):561–570. [PMC free article] [PubMed] [Google Scholar]
- Powell J. G., Jr, Cochrane R. L. The effects of a number of non-steroidal anti-inflammatory compounds on parturition in the rat. Prostaglandins. 1982 Apr;23(4):469–488. doi: 10.1016/0090-6980(82)90110-1. [DOI] [PubMed] [Google Scholar]
- Rubianes E., Rodas E., Benech A., Carrau A., Ferreira A. Lambing and placental expulsion time after dexamethasone-induced parturition in Corriedale and Polwarth ewes. Theriogenology. 1991 Aug;36(2):329–334. doi: 10.1016/0093-691x(91)90390-y. [DOI] [PubMed] [Google Scholar]
- Thorburn G. D., Challis J. R. Endocrine control of parturition. Physiol Rev. 1979 Oct;59(4):863–918. doi: 10.1152/physrev.1979.59.4.863. [DOI] [PubMed] [Google Scholar]
- Wintour E. M., Laurence B. M., Lingwood B. E. Anatomy, physiology and pathology of the amniotic and allantoic compartments in the sheep and cow. Aust Vet J. 1986 Jul;63(7):216–221. doi: 10.1111/j.1751-0813.1986.tb02999.x. [DOI] [PubMed] [Google Scholar]