Skip to main content
NCBI home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1994 Jul;58(3):157–162.

Thyroid function in dogs with spontaneous and induced congestive heart failure.

D L Panciera 1, K R Refsal 1
PMCID: PMC1263689  PMID: 7954115

Abstract

The effects of spontaneous and experimentally induced congestive heart failure on serum thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3'5'-triiodothyronine (reverse T3), free T4, free T3 concentrations, and the serum T4 and T3 concentrations in response to administration of thyrotropin were studied. Serum thyroid hormone concentrations were not different between eight dogs with spontaneous congestive heart failure and normal age matched control dogs. Seven dogs with experimental heart failure were tested before and after induction of congestive heart failure by rapid ventricular pacing. Mean serum T4 and free T3 concentrations were decreased and mean serum reverse T3 concentration was increased following induction of heart failure. The serum T4 and T3 responses to thyrotropin were not altered. Thyroid gland morphology appeared normal in dogs with experimental heart failure. Experimental congestive heart failure, similar to some other nonthyroidal illnesses, alters thyroid hormone secretion and metabolism in dogs.

Full text

PDF
157

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Calvert C. A., Chapman W. L., Jr, Toal R. L. Congestive cardiomyopathy in Doberman pinscher dogs. J Am Vet Med Assoc. 1982 Sep 15;181(6):598–602. [PubMed] [Google Scholar]
  2. Center S. A., Mitchell J., Nachreiner R. F., Concannon P. W., Reimers T. J. Effects of propranolol on thyroid function in the dog. Am J Vet Res. 1984 Jan;45(1):109–111. [PubMed] [Google Scholar]
  3. Chopra I. J., Huang T. S., Beredo A., Solomon D. H., Chua Teco G. N. Serum thyroid hormone binding inhibitor in nonthyroidal illnesses. Metabolism. 1986 Feb;35(2):152–159. doi: 10.1016/0026-0495(86)90117-4. [DOI] [PubMed] [Google Scholar]
  4. Ekins R. P., Jackson T., Sinha A., Edwards P. Principles of free hormone measurement. J Endocrinol Invest. 1986;9 (Suppl 4):3–15. [PubMed] [Google Scholar]
  5. Ekins R. The free hormone hypothesis and measurement of free hormones. Clin Chem. 1992 Jul;38(7):1289–1293. [PubMed] [Google Scholar]
  6. Ferguson D. C., Peterson M. E. Serum free and total iodothyronine concentrations in dogs with hyperadrenocorticism. Am J Vet Res. 1992 Sep;53(9):1636–1640. [PubMed] [Google Scholar]
  7. Gosselin S. J., Capen C. C., Martin S. L., Targowski S. P. Biochemical and immunological investigations on hypothyroidism in dogs. Can J Comp Med. 1980 Apr;44(2):158–168. [PMC free article] [PubMed] [Google Scholar]
  8. Hamilton M. A., Stevenson L. W., Luu M., Walden J. A. Altered thyroid hormone metabolism in advanced heart failure. J Am Coll Cardiol. 1990 Jul;16(1):91–95. doi: 10.1016/0735-1097(90)90462-x. [DOI] [PubMed] [Google Scholar]
  9. Imura H., Fukata J., Mori T. Cytokines and endocrine function: an interaction between the immune and neuroendocrine systems. Clin Endocrinol (Oxf) 1991 Aug;35(2):107–115. doi: 10.1111/j.1365-2265.1991.tb03506.x. [DOI] [PubMed] [Google Scholar]
  10. Kaptein E. M., Weiner J. M., Robinson W. J., Wheeler W. S., Nicoloff J. T. Relationship of altered thyroid hormone indices to survival in nonthyroidal illnesses. Clin Endocrinol (Oxf) 1982 Jun;16(6):565–574. doi: 10.1111/j.1365-2265.1982.tb03173.x. [DOI] [PubMed] [Google Scholar]
  11. Klein I. Thyroid hormone and the cardiovascular system. Am J Med. 1990 Jun;88(6):631–637. doi: 10.1016/0002-9343(90)90531-h. [DOI] [PubMed] [Google Scholar]
  12. Ladenson P. W., Sherman S. I., Baughman K. L., Ray P. E., Feldman A. M. Reversible alterations in myocardial gene expression in a young man with dilated cardiomyopathy and hypothyroidism. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5251–5255. doi: 10.1073/pnas.89.12.5251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Levine B., Kalman J., Mayer L., Fillit H. M., Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990 Jul 26;323(4):236–241. doi: 10.1056/NEJM199007263230405. [DOI] [PubMed] [Google Scholar]
  14. Nachreiner R. F., Refsal K. R., Ravis W. R., Hauptman J., Rosser E. J., Pedersoli W. M. Pharmacokinetics of L-thyroxine after its oral administration in dogs. Am J Vet Res. 1993 Dec;54(12):2091–2098. [PubMed] [Google Scholar]
  15. Nelson R. W., Ihle S. L., Feldman E. C., Bottoms G. D. Serum free thyroxine concentration in healthy dogs, dogs with hypothyroidism, and euthyroid dogs with concurrent illness. J Am Vet Med Assoc. 1991 Apr 15;198(8):1401–1407. [PubMed] [Google Scholar]
  16. O'Brien P. J., O'Grady M., Lumsden J. H., Holmberg D. L., Shen H., Weiler J. E., Horn R. D., Mirsalimi S. M., Julian R. J. Clinical pathologic profiles of dogs and turkeys with congestive heart failure, either noninduced or induced by rapid ventricular pacing, and turkeys with furazolidone toxicosis. Am J Vet Res. 1993 Jan;54(1):60–68. [PubMed] [Google Scholar]
  17. O'grady M. R., Holmberg D. L., Miller C. W., Cockshutt J. R. Canine congenital aortic stenosis: A review of the literature and commentary. Can Vet J. 1989 Oct;30(10):811–815. [PMC free article] [PubMed] [Google Scholar]
  18. Panciera D. L., MacEwen E. G., Atkins C. E., Bosu W. T., Refsal K. R., Nachreiner R. F. Thyroid function tests in euthyroid dogs treated with L-thyroxine. Am J Vet Res. 1990 Jan;51(1):22–26. [PubMed] [Google Scholar]
  19. Panciera D. L., Post K. Effect of oral administration of sulfadiazine and trimethoprim in combination on thyroid function in dogs. Can J Vet Res. 1992 Oct;56(4):349–352. [PMC free article] [PubMed] [Google Scholar]
  20. Pang X. P., Hershman J. M., Mirell C. J., Pekary A. E. Impairment of hypothalamic-pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-alpha (cachectin). Endocrinology. 1989 Jul;125(1):76–84. doi: 10.1210/endo-125-1-76. [DOI] [PubMed] [Google Scholar]
  21. Peterson M. E., Ferguson D. C., Kintzer P. P., Drucker W. D. Effects of spontaneous hyperadrenocorticism on serum thyroid hormone concentrations in the dog. Am J Vet Res. 1984 Oct;45(10):2034–2038. [PubMed] [Google Scholar]
  22. Punzengruber C., Weissel M. Influence of L-thyroxine on cardiac function in athyreotic thyroid cancer patients--an echophonocardiographic study. Klin Wochenschr. 1988 Aug 15;66(16):729–735. doi: 10.1007/BF01726416. [DOI] [PubMed] [Google Scholar]
  23. Reimers T. J., Lawler D. F., Sutaria P. M., Correa M. T., Erb H. N. Effects of age, sex, and body size on serum concentrations of thyroid and adrenocortical hormones in dogs. Am J Vet Res. 1990 Mar;51(3):454–457. [PubMed] [Google Scholar]
  24. Reimers T. J., Mummery L. K., McCann J. P., Cowan R. G., Concannon P. W. Effects of reproductive state on concentrations of thyroxine, 3,5,3'-triiodothyronine and cortisol in serum of dogs. Biol Reprod. 1984 Aug;31(1):148–154. doi: 10.1095/biolreprod31.1.148. [DOI] [PubMed] [Google Scholar]
  25. Vail D. M., Panciera D. L., Ogilvie G. K. Thyroid hormone concentrations in dogs with chronic weight loss, with special reference to cancer cachexia. J Vet Intern Med. 1994 Mar-Apr;8(2):122–127. doi: 10.1111/j.1939-1676.1994.tb03209.x. [DOI] [PubMed] [Google Scholar]
  26. Wu S. Y. Thyrotropin-mediated induction of thyroidal iodothyronine monodeiodinases in the dog. Endocrinology. 1983 Feb;112(2):417–424. doi: 10.1210/endo-112-2-417. [DOI] [PubMed] [Google Scholar]
  27. van der Poll T., Romijn J. A., Wiersinga W. M., Sauerwein H. P. Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J Clin Endocrinol Metab. 1990 Dec;71(6):1567–1572. doi: 10.1210/jcem-71-6-1567. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES