Skip to main content
PMC home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1995 Jan;59(1):67–69.

Antiproliferation and colony-forming inhibition activities of recombinant feline interferon (rFeIFN) on various cells in vitro.

B P Priosoeryanto 1, S Tateyama 1, R Yamaguchi 1, K Uchida 1
PMCID: PMC1263736  PMID: 7704845

Abstract

The antiproliferative and colony inhibiting activities of recombinant feline interferon (rFeIFN Type I) against various cells in vitro were examined. Feline and canine cells were both sensitive to rFeIFN. To inhibit the growth of feline cells by 50% approximately 5 x 10(2) to 1 x 10(3) U/mL rFeIFN was required and maximum activity was achieved at a concentration of 1 x 10(5) U/mL. Approximately 5 x 10(3) to 5 x 10(4) U/mL rFeIFN was necessary to inhibit the growth of canine cells by 50%. The antiproliferative and colony inhibiting activities of rFeIFN on canine cells appeared to be cell-specific and dose-dependent. However, human, monkey and hamster cells were resistant to rFeIFN. We suggest that rFeIFN might be useful for treatment of feline and some canine neoplastic conditions.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angioli R., Sevin B. U., Perras J. P., Untch M., Hightower R. D., Nguyen H. N., Steren A., Villani C., Averette H. E. Rationale of combining radiation and interferon for the treatment of cervical cancer. Oncology. 1992;49(6):445–449. doi: 10.1159/000227090. [DOI] [PubMed] [Google Scholar]
  2. Arbaje Y. M., Bittner G., Yingling J. M., Storer B., Schiller J. H. Antiproliferative effects of interferons -alpha and -beta in combination with 5-fluorouracil, cisplatin, and cis- and trans-retinoic acid in three human lung carcinoma cell lines. J Interferon Res. 1993 Feb;13(1):25–32. doi: 10.1089/jir.1993.13.25. [DOI] [PubMed] [Google Scholar]
  3. Balkwill F. R. Animal models for investigating antitumor effects of interferon. Methods Enzymol. 1986;119:649–657. doi: 10.1016/0076-6879(86)19087-2. [DOI] [PubMed] [Google Scholar]
  4. Borden E. C., Groveman D. S., Nasu T., Reznikoff C., Bryan G. T. Antiproliferative activities of interferons against human bladder carcinoma cell lines in vitro. J Urol. 1984 Oct;132(4):800–803. doi: 10.1016/s0022-5347(17)49877-6. [DOI] [PubMed] [Google Scholar]
  5. Bradley E. C., Ruscetti F. W. Effect of fibroblast, lymphoid, and myeloid interferons on human tumor colony formation in vitro. Cancer Res. 1981 Jan;41(1):244–249. [PubMed] [Google Scholar]
  6. Escudier B., Farace F., Angevin E., Triebel F., Antoun S., Leclercq B., Brandely M., Aboudaram A., Nitenberg G., Hercend T. Combination of interleukin-2 and gamma interferon in metastatic renal cell carcinoma. Eur J Cancer. 1993;29A(5):724–728. doi: 10.1016/s0959-8049(05)80354-5. [DOI] [PubMed] [Google Scholar]
  7. Fetell M. R., Housepian E. M., Oster M. W., Cote D. N., Sisti M. B., Marcus S. G., Fisher P. B. Intratumor administration of beta-interferon in recurrent malignant gliomas. A phase I clinical and laboratory study. Cancer. 1990 Jan 1;65(1):78–83. doi: 10.1002/1097-0142(19900101)65:1<78::aid-cncr2820650117>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  8. Fulton R. W., Burge L. J. Susceptibility of feline herpesvirus 1 and a feline calicivirus to feline interferon and recombinant human leukocyte interferons. Antimicrob Agents Chemother. 1985 Nov;28(5):698–699. doi: 10.1128/aac.28.5.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garbe C., Krasagakis K. Effects of interferons and cytokines on melanoma cells. J Invest Dermatol. 1993 Feb;100(2 Suppl):239S–244S. [PubMed] [Google Scholar]
  10. Halme M., Maasilta P., Mattson K., Cantell K. Pharmacokinetics and toxicity of inhaled human natural interferon-beta in patients with lung cancer. Respiration. 1994;61(2):105–107. doi: 10.1159/000196316. [DOI] [PubMed] [Google Scholar]
  11. Hansen R. M., Borden E. C. Current status of interferons in the treatment of cancer. Oncology (Williston Park) 1992 Nov;6(11):19-24; discussion 26, 29. [PubMed] [Google Scholar]
  12. Ida N., Uenishi N., Kajita A., Satoh Y. Antitumor effect of human fibroblast interferon on the growth of human melanoma cells implanted in nude mice. Gan. 1982 Dec;73(6):952–960. [PubMed] [Google Scholar]
  13. Ito M., Buffett R. F. Cytocidal effect of purified human fibroblast interferon on tumor cells in vitro. J Natl Cancer Inst. 1981 May;66(5):819–825. [PubMed] [Google Scholar]
  14. Kataoka T., Oh-hashi F., Sakurai Y., Ida N. Characteristics of in vitro antiproliferation activity of human interferon-beta. Cancer Chemother Pharmacol. 1982;9(2):75–80. doi: 10.1007/BF00265382. [DOI] [PubMed] [Google Scholar]
  15. Kohno M., Ida N., Nagao S., Tanaka N., Sekiguchi F., Uenishi N., Kajita A., Ogawa H. Effects of human fibroblast interferon on human tumors transplanted into nude mice: sensitivity of human tumors to interferon. Gan. 1982 Dec;73(6):945–951. [PubMed] [Google Scholar]
  16. Kopp W. C., Smith J. W., 2nd, Ewel C. H., Alvord W. G., Main C., Guyre P. M., Steis R. G., Longo D. L., Urba W. J. Immunomodulatory effects of interferon-gamma in patients with metastatic malignant melanoma. J Immunother Emphasis Tumor Immunol. 1993 Apr;13(3):181–190. doi: 10.1097/00002371-199304000-00005. [DOI] [PubMed] [Google Scholar]
  17. Pyrhönen S., Hahka-Kemppinen M., Muhonen T. A promising interferon plus four-drug chemotherapy regimen for metastatic melanoma. J Clin Oncol. 1992 Dec;10(12):1919–1926. doi: 10.1200/JCO.1992.10.12.1919. [DOI] [PubMed] [Google Scholar]
  18. Rosso R., Nobile M. T., Sertoli M. R., Giannitelli A., Santi P. L., Volpe R., Nicolò G. Antitumoral activity of human fibroblast interferon administered intranodularly. Oncology. 1985;42(2):86–88. doi: 10.1159/000226006. [DOI] [PubMed] [Google Scholar]
  19. Sakurai T., Ueda Y., Sato M., Yanai A. Feline interferon production in silkworm by recombinant baculovirus. J Vet Med Sci. 1992 Jun;54(3):563–565. doi: 10.1292/jvms.54.563. [DOI] [PubMed] [Google Scholar]
  20. Ueda Y., Sakurai T., Kasama K., Satoh Y., Atsumi K., Hanawa S., Uchino T., Yanai A. Pharmacokinetic properties of recombinant feline interferon and its stimulatory effect on 2',5'-oligoadenylate synthetase activity in the cat. J Vet Med Sci. 1993 Feb;55(1):1–6. doi: 10.1292/jvms.55.1. [DOI] [PubMed] [Google Scholar]
  21. Ueda Y., Sakurai T., Yanai A. Homogeneous production of feline interferon in silkworm by replacing single amino acid code in signal peptide region in recombinant baculovirus and characterization of the product. J Vet Med Sci. 1993 Apr;55(2):251–258. doi: 10.1292/jvms.55.251. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES