Correction: Cell. Mol. Life Sci. (2012) 69:3665–3681
10.1007/s00018-012-1045-y.
In this article Fig(s) 7 and 8 appeared incorrectly and have now been corrected in the original publication. For completeness and transparency, the old incorrect versions are displayed below.
Incorrect figure
Fig. 7 Increased CTF-β and Aβ trimeric forms in the cortex of MT1 + 2 null males. a, b Representative WB band pattern obtained with 6E10 antibody in total cortical homogenates and fraction C (membrane-associated protein enriched fraction), respectively, of male mice. Apart from the specific bands mentioned in Fig. 6, a 14-kDa band, that by its size could represent a trimer of Aβ, was also quantified. MT1 + 2 deficiency in APP+ male mice significantly increased CTF-β and putative Aβ trimer levels in total cortical homogenates (c), and Aβ trimer levels in Fraction C (d). Analysis of female mice total cortical homogenates (e) showed no differences between APP+ genotypes, while in the extracellular protein enriched fraction (f) the 14-kDa band was significantly decreased by MT1 + 2 deficiency. Data represents mean ± SEM (n = 8–13). Plus, p at least ≤0.03 versus APPWT mice
Corrected figure
Fig. 7 Increased CTF-β and Aβ trimeric forms in the cortex of MT1 + 2 null males. a, b Representative WB band pattern obtained with 6E10 antibody in total cortical homogenates and fraction C membrane-associated protein enriched fraction), respectively, of male mice. Apart from the specific bands mentioned in Fig. 6, a14-kDa band, that by its size could represent a trimer of Aβ, was also quantified. MT1 + 2 deficiency in APP+ male mice significantly increased CTF- β and putative Aβ trimer levels in total cortical homogenates (c), and Aβ trimer levels in Fraction C (d). Analysis of female mice total cortical homogenates (e) showed no differences between APP+ genotypes, while in the extracellular protein enriched fraction (f) the 14-kDa band was significantly decreased by MT1 + 2 deficiency. Data represents mean ± SEM (n = 8–13). Plus, p at least ≤0.03 versus APPWT mice
Incorrected figure
Fig. 8 APP-induced microgliosis is prevented by MT1 + 2 absence in males. Total cortex and hippocampus homogenates were assayed by WB. a Representative WB obtained with anti-GFAP and anti-Iba1 antibodies in cortex; anti-actin antibodies were used for loading controls and data normalization. b APP+ males showed significantly higher GFAP levels (reflecting astrocytosis) than APP- genotypes in both hippocampal (left) and cortical (right) homogenates. However, no effect due to MT1 + 2 absence was observed in GFAP levels in none of the regions assessed. c Similarly to astrocytosis, Iba1 levels were also increased by hAPP presence compared to controls (reflecting microgliosis), but in this case, MT1 + 2 deficiency significantly prevented this effect. Data represents mean ± SEM (n = 9) and was analyzed using GLZ with APP and MT deficiency as main factors. Filled diamond, p ≤ 0.001 versus APP-; spade, p ≤ 0.04 significant interaction between factors
Corrected figure
Fig. 8 APP-induced microgliosis is prevented by MT1 + 2 absence in males. Total cortex and hippocampus homogenates were assayed by WB. a Representative WB obtained with anti-GFAP and anti-Iba1 antibodies in cortex; anti-actin antibodies were used for loading controls and data normalization. b APP+ males showed significantly higher GFAP levels (reflecting astrocytosis) than APP- genotypes in both hippocampal (left) and cortical (right) homogenates. However, no effect due to MT1 + 2 absence was observed in GFAP levels in none of the regions assessed. c Similarly to astrocytosis, Iba1 levels were also increased by hAPP presence compared to controls (reflecting microgliosis), but in this case, MT1 + 2 deficiency significantly prevented this effect. Data represents mean ± SEM (n = 9) and was analyzed using GLZ with APP and MT deficiency as main factors. Filled diamond, p ≤ 0.001 versus APP-; spade, p ≤ 0.04 significant interaction between factors
The original article has been corrected.
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