Abstract
1. A series of oligosaccharides was isolated from Salmonella milwaukee lipopolysaccharide by partial acid hydrolysis. 2. Structural studies on these oligosaccharides indicated that the O-specific side chain of this lipopolysaccharide has a repeating pentasaccharide unit that is probably α-d-galactosyl-(1→3)-β-d-galactosyl- (1→3)-N-acetylgalactosaminyl-(1→3)-N-acetyl- d-glucosaminyl-(1→4)-l-fucose. 3. Another oligosaccharide, which is not structurally related to the repeating pentasaccharide unit, has also been isolated and it is indistinguishable from an oligosaccharide obtained from Salmonella `rough' (R) lipopolysaccharides. The isolation of this and similar core oligosaccharides from all chemotype VI lipopolysaccharides supports the view that Salmonella S-lipopolysaccharides have a common core that is probably identical with RII lipopolysaccharide.
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- FOSTER A. B., HORTON D. Aspects of the chemistry of the amino sugars. Adv Carbohydr Chem. 1959;14:213–281. doi: 10.1016/s0096-5332(08)60225-8. [DOI] [PubMed] [Google Scholar]
- KAUFFMANN F., LUEDERITZ O., STIERLIN H., WESTPHAL O. [On the immunochemistry of O antigens of Enterobacteriaceae. I. Analysis of the sugar component of Salmonella O antigens]. Zentralbl Bakteriol. 1960 May;178:442–458. [PubMed] [Google Scholar]
- NIKAIDO H. Studies on the biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. II. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1542–1548. doi: 10.1073/pnas.48.9.1542. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osborn M. J., Rosen S. M., Rothfield L., Horecker B. L. Galactose Incorporation into Cell-Wall Lipopolysaccharide in Mutant Strain of Salmonella typhimurium. Science. 1962 Apr 27;136(3513):328–328. doi: 10.1126/science.136.3513.328-b. [DOI] [PubMed] [Google Scholar]
- REGE V. P., PAINTER T. J., WATKINS W. M., MORGAN W. T. THREE NEW TRISACCHARIDES OBTAINED FROM HUMAN BLOOD-GROUP A, B, H AND LEA SUBSTANCES: POSSIBLE SUGAR SEQUENCES IN THE CARBOHYDRATE CHAINS. Nature. 1963 Nov 9;200:532–534. doi: 10.1038/200532a0. [DOI] [PubMed] [Google Scholar]
- ROBBINS P. W., UCHIDA T. Studies on the chemical basis of the phage conversion of O-antigens in the E-group Salmonellae. Biochemistry. 1962 Mar;1:323–335. doi: 10.1021/bi00908a020. [DOI] [PubMed] [Google Scholar]
- SCHIFFMAN G., KABAT E. A., THOMPSON W. IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS. XXXII. IMMUNOCHEMICAL PROPERTIES OF AND POSSIBLE PARTIAL STRUCTURES FOR THE BLOOD GROUP A, B, AND H ANTIGENIC DETERMINANTS. Biochemistry. 1964 Apr;3:587–593. doi: 10.1021/bi00892a020. [DOI] [PubMed] [Google Scholar]
- Simmons D. A., Lüderitz O., Westphal O. The immunochemistry of Salmonella chemotype VI O-antigens. The structure of oligosaccharides from Salmonella group G (o 13,22) lipopolysaccharides. Biochem J. 1965 Dec;97(3):807–814. doi: 10.1042/bj0970807. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simmons D. A., Lüderitz O., Westphal O. The immunochemistry of Salmonella chemotype VI O-antigens. The structure of oligosaccharides from Salmonella group N (o 30) lipopolysaccharides. Biochem J. 1965 Dec;97(3):815–819. doi: 10.1042/bj0970815. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutherland I. W., Lüderitz O., Westphal O. Studies on the structure of lipopolysaccharides of Salmonella minnesota and Salmonella typhimurium R strains. Biochem J. 1965 Aug;96(2):439–448. doi: 10.1042/bj0960439. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WALLENFELS K., KURZ G. [On the specificity of galactose dehydrogenase from Pseudomonas saccharophila and its use as an analytical aid]. Biochem Z. 1962;335:559–573. [PubMed] [Google Scholar]
- WASSERMAN E., LEVINE L. Quantitative micro-complement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J Immunol. 1961 Sep;87:290–295. [PubMed] [Google Scholar]