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. 1966 Feb;98(2):630–635. doi: 10.1042/bj0980630

Methionine synthesis by extracts of Salmonella typhimurium

Sally E Cauthen 1,*, M A Foster 1, D D Woods 1,†
PMCID: PMC1264886  PMID: 5328768

Abstract

1. Following the genetic studies by Smith (1961) and Smith & Childs (1963) with methionine auxotrophs of Salmonella typhimurium, methionine formation from homocysteine has been investigated with cell-free extracts of this organism. 2. As found with Escherichia coli (Woods, Foster & Guest, 1964), methyl groups are formed by an N5N10-methylenetetrahydrofolate reductase. They are then transferred to homocysteine by either a simple N5-methyltetrahydropteroyl-triglutamate–homocysteine methyltransferase or alternatively a cobalamin-dependent N5-methyltetrahydrofolate–homocysteine methyltransferase. 3. S. typhimurium differs from E. coli in being able to synthesize significant amounts of cobalamin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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