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. 1966 Mar;98(3):858–861. doi: 10.1042/bj0980858

The proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity

K J Dorrington 1, L Carneiro 1, D S Munro 1
PMCID: PMC1264928  PMID: 4161715

Abstract

1. Proteolysis of immunoglobulin G with long-acting thyroid-stimulating activity with papain and pepsin shortened the duration of thyroid stimulation in mice prepared for the McKenzie (1958) bioassay. The time-course appeared to be related to molecular size. 2. The activity after proteolysis was recovered solely in the electrophoretically slow Fab-fragment. 3. There was no immunological cross-reaction between pituitary thyroid-stimulating hormone and the active fragments of the long-acting thyroid stimulator despite their similar behaviour in the bioassay. 4. The implications of these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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