Abstract
1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.
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Selected References
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- ALDRIDGE W. N., DAVISON A. N. The mechanism of inhibition of cholinesterases by organophosphorus compounds. Biochem J. 1953 Dec;55(5):763–766. doi: 10.1042/bj0550763. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHILDS A. F., DAVIES D. R., GREEN A. L., RUTLAND J. P. The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds. Br J Pharmacol Chemother. 1955 Dec;10(4):462–465. doi: 10.1111/j.1476-5381.1955.tb00106.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOBBIGER F. Effect of nicotinhydroxamic acid methiodide on human plasma cholinesterase inhibited by organophosphates containing a dialkylphosphato group. Br J Pharmacol Chemother. 1955 Sep;10(3):356–362. doi: 10.1111/j.1476-5381.1955.tb00884.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOBBIGER F. Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide. Br J Pharmacol Chemother. 1957 Dec;12(4):438–446. doi: 10.1111/j.1476-5381.1957.tb00162.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JANSZ H. S., BRONS D., WARRINGA M. G. Chemical nature of the DFP-binding site of pseudocholinesterase. Biochim Biophys Acta. 1959 Aug;34:573–575. doi: 10.1016/0006-3002(59)90320-8. [DOI] [PubMed] [Google Scholar]
- LOOMIS T. A., SALAFSKY B. ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION. Toxicol Appl Pharmacol. 1963 Nov;5:685–701. doi: 10.1016/0041-008x(63)90062-0. [DOI] [PubMed] [Google Scholar]