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. 1966 Apr;99(1):22–27. doi: 10.1042/bj0990022

Metabolism of d-glucuronolactone in mammalian systems. Inhibitory properties of the products of d-glucuronolactone-dehydrogenase action

C A Marsh 1,*
PMCID: PMC1264951  PMID: 5965340

Abstract

1. d-Glucuronolactone was converted into d-glucaro-(1→4)-lactone, a β-glucuronidase inhibitor, probably via the intermediate d-glucaro-(1→4)-(6→3)-dilactone, by a dehydrogenase in human-liver extracts. 2. Similar experiments with mouse-liver extracts appeared to yield only d-glucaric acid or a non-inhibitory lactone. 3. A strong β-glucuronidase inhibitor was present in mouse liver after the intraperitoneal administration of d-glucuronolactone. 4. d-Glucarodilactone decomposed spontaneously in aqueous solution to give 25% of d-glucaro-(1→4)-lactone; the percentage conversion was unaffected by human-liver homogenates. but considerably increased by mouse-liver or pig-liver fractions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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