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. 1966 May;99(2):396–403. doi: 10.1042/bj0990396

The adenosine diphosphate–adenosine triphosphate-exchange reaction of cerebral microsomes and its relation to the sodium ion-stimulated adenosine-triphosphatase reaction

P D Swanson 1, W L Stahl 1,*
PMCID: PMC1265008  PMID: 4223369

Abstract

Microsomes from guinea-pig cerebral cortex contain a system capable of exchanging ADP with ATP at rates of about 20μmoles/mg. of protein/hr. The ADP–ATP-exchange reaction requires Mg2+ for activity. The reaction is not stimulated by Na+ or K+ and is not inhibited by ouabain, in contrast with the Na+-plus-K+-stimulated adenosine triphosphatase. The pH optimum also differs from that of the adenosine triphosphatase. The ADP–ATP-exchange reaction is stimulated two- to three-fold by non-ionic, anionic and cationic detergents, even when these agents are inhibiting the adenosine-triphosphatase reaction. This reaction may represent a component of the Na+-plus-K+-stimulated adenosine-triphosphatase reaction but is more likely to be due to other enzyme systems present in microsomal subfractions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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