Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1966 Sep;100(3):652–660. doi: 10.1042/bj1000652

Bile salts and calcium absorption

D D'A Webling 1, E S Holdsworth 1,*
PMCID: PMC1265197  PMID: 4291037

Abstract

1. The study of the effect of bile salts on enhancing calcium absorption in the rachitic chick has been extended to bile salts not present in chick bile, e.g. glycine conjugates and bile alcohol sulphates. 2. Bile and bile salts cause an increase in calcium absorption from sparingly soluble calcium hydrogen phosphate when compared with a suspension of calcium hydrogen phosphate in saline. 3. If the bile ducts of normal rats are tied the absorption of calcium from calcium hydrogen phosphate decreases but can be restored by giving bile salts with the calcium salt. 4. Bile salts increase solubility in water of the sparingly soluble calcium salts, phytate and phosphate at pH values between 6 and 8. 5. Bile salts increase the solubility in lipid solvents of calcium in approximately the same proportion as they increase the absorption of calcium from the gut. 6. The physiological role of bile in calcium absorption and its mode of action are discussed.

Full text

PDF
652

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COATES M. E., HOLDSWORTH E. S. Vitamin D3 and absorption of calcium in the chick. Br J Nutr. 1961;15:131–147. doi: 10.1079/bjn19610014. [DOI] [PubMed] [Google Scholar]
  2. GORDON B. A., KUKSIS A., BEVERIDGE J. M. Separation of bile acid conjugates by ion exchange chromatography. Can J Biochem Physiol. 1963 Jan;41:77–89. [PubMed] [Google Scholar]
  3. HARRISON H. E., HARRISON H. C. VITAMIN D AND PERMEABILITY OF INTESTINAL MUCOSA TO CALCIUM. Am J Physiol. 1965 Feb;208:370–374. doi: 10.1152/ajplegacy.1965.208.2.370. [DOI] [PubMed] [Google Scholar]
  4. Holdsworth E. S. Vitamin D3 and calcium absorption in the chick. Biochem J. 1965 Aug;96(2):475–483. doi: 10.1042/bj0960475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. SALLIS J. D., HOLDSWORTH E. S. Influence of vitamin D on calcium absorption in the chick. Am J Physiol. 1962 Sep;203:497–505. doi: 10.1152/ajplegacy.1962.203.3.497. [DOI] [PubMed] [Google Scholar]
  6. Webling D. D., Holdsworth E. S. The effect of bile, bile acids and detergents on calcium absorption in the chick. Biochem J. 1965 Nov;97(2):408–421. doi: 10.1042/bj0970408. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES