Abstract
Gallium-67 scintigraphy has been of limited use in detecting lung cancers and micrometastases. To study its potential for determining the aggressiveness of a cancer, we reviewed the charts of 44 patients with non-small-cell bronchogenic carcinoma who had not been receiving treatment when 67Ga scintigraphy was performed. The mean length of survival for the 18 patients with low or little uptake of the tracer, corrected for tumour size, was 19.7 months, and for the 26 with high uptake 9.4 months (p less than 0.01). Such in-vivo predictive assays may be a rational goal for tumour scintigraphy.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alazraki N. P., Ramsdell J. W., Taylor A., Friedman P. J., Peters R. M., Tisi G. M. Reliability of gallium scan chest radiography compared to mediastinoscopy for evaluating mediastinal spread in lung cancer. Am Rev Respir Dis. 1978 Mar;117(3):415–420. doi: 10.1164/arrd.1978.117.3.415. [DOI] [PubMed] [Google Scholar]
- Alazraki N. Usefulness of gallium imaging in the evaluation of lung cancer. Crit Rev Diagn Imaging. 1980;13(3):249–267. [PubMed] [Google Scholar]
- Bekerman C., Hoffer P. B., Bitran J. D. The role of gallium-67 in the clinical evaluation of cancer. Semin Nucl Med. 1984 Oct;14(4):296–323. doi: 10.1016/s0001-2998(84)80005-7. [DOI] [PubMed] [Google Scholar]
- Bichel P., Hansen H. H. The incorporation of 67 Ga in normal and malignant cells and its dependence on growth rate. Br J Radiol. 1972 Mar;45(531):182–184. doi: 10.1259/0007-1285-45-531-182. [DOI] [PubMed] [Google Scholar]
- Bidani N., Kirchner P. T., Moohr J. W., Radkowski M. A., Pang E., Cooper M. Gallium scan as a prognostic indicator in neuroblastoma. Clin Nucl Med. 1980 Oct;5(10):450–453. doi: 10.1097/00003072-198010000-00003. [DOI] [PubMed] [Google Scholar]
- DeLand F. H., Sauerbrunn J. L., Boyd C., Wilkinson R. H., Jr, Friedman B. I., Moinuddin M., Preston D. F., Kniseley R. M. 67Ga-citrate imaging in untreated primary lung cancer: preliminary report of Cooperative Group. J Nucl Med. 1974 Jun;15(6):408–411. [PubMed] [Google Scholar]
- DeMeester T. R., Bekerman C., Joseph J. G., Toscano M. S., Golomb H., Bitran J., Gross N. J., Skinner D. B. Gallium-67 scanning for carcinoma of the lung. J Thorac Cardiovasc Surg. 1976 Nov;72(5):699–708. [PubMed] [Google Scholar]
- Fletcher J. W., Herbig F. K., Donati R. M. 67Ga citrate distribution following whole-body irradiation or chemotherapy. Radiology. 1975 Dec;117(3 Pt 1):709–712. doi: 10.1148/117.3.709. [DOI] [PubMed] [Google Scholar]
- Fosburg R. G., Hopkins G. B., Kan M. K. Evaluation of the mediastinum by gallium-67 scintigraphy in lung cancer. J Thorac Cardiovasc Surg. 1979 Jan;77(1):76–82. [PubMed] [Google Scholar]
- Glass R. B., Fernbach S. K., Conway J. J., Shkolnik A. Gallium scintigraphy in American Burkitt lymphoma: accurate assessment of tumor load and prognosis. AJR Am J Roentgenol. 1985 Oct;145(4):671–676. doi: 10.2214/ajr.145.4.671. [DOI] [PubMed] [Google Scholar]
- Gleason D. F., Mellinger G. T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol. 1974 Jan;111(1):58–64. doi: 10.1016/s0022-5347(17)59889-4. [DOI] [PubMed] [Google Scholar]
- Higashi T., Nakamura K., Suzuki S., Allison J. R., Wakao H. Ga-67 scan as a prognostic indicator in primary lung carcinoma. Clin Nucl Med. 1982 Dec;7(12):553–557. doi: 10.1097/00003072-198212000-00005. [DOI] [PubMed] [Google Scholar]
- Ito Y., Okuyama S., Awano T., Takahashi K., Sato T. Diagnostic evaluation of 67 Ga scanning of lung cancer and other diseases. Radiology. 1971 Nov;101(2):355–362. doi: 10.1148/101.2.355. [DOI] [PubMed] [Google Scholar]
- Jackson F. I., McPherson T. A., Lentle B. C. Gallium-67 scintigraphy in multisystem malignant melanoma. Radiology. 1977 Jan;122(1):163–167. doi: 10.1148/122.1.163. [DOI] [PubMed] [Google Scholar]
- Kaneko Y., Rowley J. D., Variakojis D., Haren J. M., Ueshima Y., Daly K., Kluskens L. F. Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma. Int J Cancer. 1983 Dec 15;32(6):683–692. doi: 10.1002/ijc.2910320606. [DOI] [PubMed] [Google Scholar]
- Larson S. M., Carrasquillo J. A. Nuclear oncology 1984. Semin Nucl Med. 1984 Oct;14(4):268–276. doi: 10.1016/s0001-2998(84)80002-1. [DOI] [PubMed] [Google Scholar]
- Lentle B. C., Scott J. R., Noujaim A. A., Jackson F. I. Iatrogenic alterations in radionuclide biodistributions. Semin Nucl Med. 1979 Apr;9(2):131–143. doi: 10.1016/s0001-2998(79)80045-8. [DOI] [PubMed] [Google Scholar]
- Lentle B. C., Scott J. R., Schmidt R. P., Hooper H. R., Catz Z. The clinical value of direct tumor scintigraphy: a new hypothesis. J Nucl Med. 1985 Oct;26(10):1215–1217. [PubMed] [Google Scholar]
- McCoy J. P., Jr, Goldstein I. J., Varani J. A review of studies in our laboratory regarding ELLA methodology for the study of cell surface carbohydrates from tumors of varying metastatic potential. Tumour Biol. 1985;6(2):99–114. [PubMed] [Google Scholar]
- Thesingh C. W., Driessen O. M., Daems W. T., Franken C., Pauwels E. K., Scheffer E., Vermeij J., Wisse E. Accumulation and localization of gallium-67 in various types of primary lung carcinoma. J Nucl Med. 1978 Jan;19(1):28–30. [PubMed] [Google Scholar]
- Trowbridge I. S., Omary M. B. Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc Natl Acad Sci U S A. 1981 May;78(5):3039–3043. doi: 10.1073/pnas.78.5.3039. [DOI] [PMC free article] [PubMed] [Google Scholar]
