Abstract
We wished to compare the frequency of group-specific (Gc) phenotypes in the general population with that in people with human immunodeficiency virus (HIV) infection to find out whether the Gc protein is a marker for susceptibility to HIV infection. We determined the phenotype frequency in 1083 randomly selected serum samples obtained from the Canadian Influenza Survey Studies and compared it with that in 263 serum samples obtained from the Federal Centre for AIDS and the Syphilis Serology Proficiency Testing Laboratory. No association between Gc phenotype and HIV status was found. However, there was a strong association between the Gc protein 1f/1f phenotype and syphilis.
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- Brown I. R., Carter N. D., Sood A. Vitamin D binding globulin phenotypes in liver disease. Clin Chim Acta. 1979 Jul 2;95(1):75–82. doi: 10.1016/0009-8981(79)90338-3. [DOI] [PubMed] [Google Scholar]
- Constans J., Cleve H. Group-specific component. Report on the First International Workshop, Collège de France--July 27-28, 1978--Paris. Hum Genet. 1979 Apr 27;48(2):143–149. doi: 10.1007/BF00286897. [DOI] [PubMed] [Google Scholar]
- Constans J., Viau M. Group-specific component: evidence for two subtypes of the Gc1 gene. Science. 1977 Dec 9;198(4321):1070–1071. doi: 10.1126/science.73222. [DOI] [PubMed] [Google Scholar]
- Eales L. J., Nye K. E., Parkin J. M., Weber J. N., Forster S. M., Harris J. R., Pinching A. J. Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection. Lancet. 1987 May 2;1(8540):999–1002. doi: 10.1016/s0140-6736(87)92269-0. [DOI] [PubMed] [Google Scholar]
- Genetic susceptibility to AIDS: absence of an association with group-specific component (Gc) N Engl J Med. 1987 Sep 3;317(10):630–632. doi: 10.1056/NEJM198709033171012. [DOI] [PubMed] [Google Scholar]
- Haddad J. G., Jr, Walgate J. 25-Hydroxyvitamin D transport in human plasma. Isolation and partial characterization of calcifidiol-binding protein. J Biol Chem. 1976 Aug 25;251(16):4803–4809. [PubMed] [Google Scholar]
- Nel A. E., Navailles M., Emerson D. L., Goldschmidt-Clermont P., Pathak S. K., Tsang K. Y., Galbraith R. M. Altered configuration of Gc on the plasma membrane of transformed and malignant human B lymphocytes. Clin Immunol Immunopathol. 1985 Nov;37(2):191–202. doi: 10.1016/0090-1229(85)90150-3. [DOI] [PubMed] [Google Scholar]
- Papiha S. S., Pal B. Gc (vitamin D binding protein) subtypes in rheumatoid arthritis. Hum Genet. 1985;70(3):278–280. doi: 10.1007/BF00273457. [DOI] [PubMed] [Google Scholar]
- Petrini M., Galbraith R. M., Emerson D. L., Nel A. E., Arnaud P. Structural studies of T lymphocyte Fc receptors. Association of Gc protein with IgG binding to Fc gamma. J Biol Chem. 1985 Feb 10;260(3):1804–1810. [PubMed] [Google Scholar]
- Potterat J. J. Does syphilis facilitate sexual acquisition of HIV? JAMA. 1987 Jul 24;258(4):473–474. doi: 10.1001/jama.1987.03400040071016. [DOI] [PubMed] [Google Scholar]